Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation

Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation

Phosphatidylinositol 4,5-biphosphate kinases (PIP5K) are critical regulators of T cell activation being the main enzymes involved in the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2). PIP2 is indeed a pivotal regulator of the actin cytoskeleton, thus controlling T cell polarization and mi...

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Bibliographic Details
Main Authors: Loretta eTuosto, Nicla ePorciello, Martina eKunkl, Antonella eViola
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Immunology
Subjects:
Actin Cytoskeleton
Metabolism
CD28
T cell signaling
PIP5K
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00186/full
Description
Summary:Phosphatidylinositol 4,5-biphosphate kinases (PIP5K) are critical regulators of T cell activation being the main enzymes involved in the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2). PIP2 is indeed a pivotal regulator of the actin cytoskeleton, thus controlling T cell polarization and migration, stable adhesion to antigen presenting cells (APC), spatial organization of the immunological synapse (IS), and costimulation. Moreover, PIP2 serves also as a precursor for the second messengers inositol triphosphate (IP3), diacylglycerol (DAG) and phosphatidylinositol 3,4,5-triphosphate (PIP3), which are essential for the activation of signalling pathways regulating cytokine production, cell cycle progression, survival, metabolism and differentiation. Here, we discuss the impact of PIP5Ks on several T lymphocyte functions with a specific focus on the role of CD28 co-stimulation in PIP5K compartimentalization and activation.
ISSN:1664-3224

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