Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation

Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation

Phosphatidylinositol 4,5-biphosphate kinases (PIP5K) are critical regulators of T cell activation being the main enzymes involved in the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2). PIP2 is indeed a pivotal regulator of the actin cytoskeleton, thus controlling T cell polarization and mi...

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Bibliographic Details
Main Authors: Loretta eTuosto, Nicla ePorciello, Martina eKunkl, Antonella eViola
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Immunology
Subjects:
Actin Cytoskeleton
Metabolism
CD28
T cell signaling
PIP5K
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00186/full

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