Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis

Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis

Summary: The processes underlying synchronous multiple organ fibrosis in systemic sclerosis (SSc) remain poorly understood. Age-related pathologies are associated with organismal decline in nicotinamide adenine dinucleotide (NAD+) that is due to dysregulation of NAD+ homeostasis and involves the NAD...

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Main Authors: Bo Shi, Wenxia Wang, Benjamin Korman, Li Kai, Qianqian Wang, Jun Wei, Swarna Bale, Roberta Goncalves Marangoni, Swati Bhattacharyya, Stephen Miller, Dan Xu, Mahzad Akbarpour, Paul Cheresh, Daniele Proccissi, Demirkan Gursel, Jair Machado Espindola-Netto, Claudia C.S. Chini, Guilherme C. de Oliveira, Johann E. Gudjonsson, Eduardo N. Chini, John Varga
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Human Metabolism
Molecular Biology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220310993

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