Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry
Objective Still’s disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still’s disease represent expressions of the same disease continuum or di...
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| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023-10-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/9/4/e003578.full |
| _version_ | 1797366470003392512 |
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| author | Micol Frassi Marcello Govoni Annamaria Iagnocco Florenzo Iannone Paola Triggianese Corrado Campochiaro Sara Monti Maria G Tektonidou Eduardo Martin-Nares Piero Ruscitti Roberto Giacomelli Luca Cantarini Giuseppe Lopalco Lorenzo Dagna Francesco Carubbi Alma Nunzia Olivieri Antonio Vitale Ombretta Viapiana Fatma Alibaz-Öner Haner Direskeneli Petros P Sfikakis Giacomo Emmi Claudia Fabiani Gabriele Simonini Francesco Ciccia Elena Bartoloni Alessandro Tomelleri Daniela Iacono Riza Can Kardas Bruno Frediani Benson Ogunjimi Amato de Paulis Onorina Berardicurti Alessandro Conforti Ilenia Di Cola Anastasios Karamanakos Katerina Laskari Abdurrahman Tufan Stefania Costi José Hernández-Rodríguez Lampros Fotis Jurgen Sota Antonio Gidaro Ewa Wiesik-Szewczyk Gian Domenico Sebastiani Jiram Torres-Ruiz Paolo Sfriso Giovanni Conti Luca Navarini Francesco La Torre Samar Tharwat Andrea Hinojosa-Azaola Alberto Lo Gullo Valeria Caggiano Ibrahim A Almaghlouth Kazi Asfina Gafaar Ragab Maria Cristina Maggio Joanna Makowska Emanuela Del Giudice Armin Maier Sukran Erten Henrique A Mayrink Giardini Maria Morrone Isabele Parente de Brito Antonelli Marilia Ambiel Dagostin Martina Patrone Fehaid Alanazi Carla Gaggiano Hamit Kucuk Ayman Abdel-Monem Ahmed Mahmoud Katerina Kourtesi Maria Tarsia Verónica Gómez-Caverzaschi Angela Mauro Alberto Balistreri |
| author_facet | Micol Frassi Marcello Govoni Annamaria Iagnocco Florenzo Iannone Paola Triggianese Corrado Campochiaro Sara Monti Maria G Tektonidou Eduardo Martin-Nares Piero Ruscitti Roberto Giacomelli Luca Cantarini Giuseppe Lopalco Lorenzo Dagna Francesco Carubbi Alma Nunzia Olivieri Antonio Vitale Ombretta Viapiana Fatma Alibaz-Öner Haner Direskeneli Petros P Sfikakis Giacomo Emmi Claudia Fabiani Gabriele Simonini Francesco Ciccia Elena Bartoloni Alessandro Tomelleri Daniela Iacono Riza Can Kardas Bruno Frediani Benson Ogunjimi Amato de Paulis Onorina Berardicurti Alessandro Conforti Ilenia Di Cola Anastasios Karamanakos Katerina Laskari Abdurrahman Tufan Stefania Costi José Hernández-Rodríguez Lampros Fotis Jurgen Sota Antonio Gidaro Ewa Wiesik-Szewczyk Gian Domenico Sebastiani Jiram Torres-Ruiz Paolo Sfriso Giovanni Conti Luca Navarini Francesco La Torre Samar Tharwat Andrea Hinojosa-Azaola Alberto Lo Gullo Valeria Caggiano Ibrahim A Almaghlouth Kazi Asfina Gafaar Ragab Maria Cristina Maggio Joanna Makowska Emanuela Del Giudice Armin Maier Sukran Erten Henrique A Mayrink Giardini Maria Morrone Isabele Parente de Brito Antonelli Marilia Ambiel Dagostin Martina Patrone Fehaid Alanazi Carla Gaggiano Hamit Kucuk Ayman Abdel-Monem Ahmed Mahmoud Katerina Kourtesi Maria Tarsia Verónica Gómez-Caverzaschi Angela Mauro Alberto Balistreri |
| author_sort | Micol Frassi |
| collection | DOAJ |
| description | Objective Still’s disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still’s disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still’s disease.Methods Subjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still’s disease.Results A total of 411 patients suffering from Still’s disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still’s disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p<0.0001) were significantly more frequent among elderly-onset patients compared with paediatric-onset subjects. Regarding laboratory data, thrombocytosis was significantly more frequent among paediatric patients onset compared with adult-onset subjects (p<0.0001), while thrombocytopenia was more frequent among elderly-onset patients although statistical significance was only bordered. No substantial differences were observed in the response to treatments.Conclusions Despite some minor difference between groups, overall, demographic, clinical, laboratory and treatments aspects of Still’s disease were similarly observed in patients at all ages. This supports that pediatric-onset, adult-onset and elderly-onset Still’s disease is the same clinical condition arising in different ages. |
| first_indexed | 2024-03-08T17:05:33Z |
| format | Article |
| id | doaj.art-0de8c96601294cee9d1dac1839434208 |
| institution | Directory Open Access Journal |
| issn | 2056-5933 |
| language | English |
| last_indexed | 2024-03-08T17:05:33Z |
| publishDate | 2023-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj.art-0de8c96601294cee9d1dac18394342082024-01-04T05:20:08ZengBMJ Publishing GroupRMD Open2056-59332023-10-019410.1136/rmdopen-2023-003578Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registryMicol Frassi0Marcello Govoni1Annamaria Iagnocco2Florenzo Iannone3Paola Triggianese4Corrado Campochiaro5Sara Monti6Maria G Tektonidou7Eduardo Martin-Nares8Piero Ruscitti9Roberto Giacomelli10Luca Cantarini11Giuseppe Lopalco12Lorenzo Dagna13Francesco Carubbi14Alma Nunzia Olivieri15Antonio Vitale16Ombretta Viapiana17Fatma Alibaz-Öner18Haner Direskeneli19Petros P Sfikakis20Giacomo Emmi21Claudia Fabiani22Gabriele Simonini23Francesco Ciccia24Elena Bartoloni25Alessandro Tomelleri26Daniela Iacono27Riza Can Kardas28Bruno Frediani29Benson Ogunjimi30Amato de Paulis31Onorina Berardicurti32Alessandro Conforti33Ilenia Di Cola34Anastasios Karamanakos35Katerina Laskari36Abdurrahman Tufan37Stefania Costi38José Hernández-Rodríguez39Lampros Fotis40Jurgen Sota41Antonio Gidaro42Ewa Wiesik-Szewczyk43Gian Domenico Sebastiani44Jiram Torres-Ruiz45Paolo Sfriso46Giovanni Conti47Luca Navarini48Francesco La Torre49Samar Tharwat50Andrea Hinojosa-Azaola51Alberto Lo Gullo52Valeria Caggiano53Ibrahim A Almaghlouth54Kazi Asfina55Gafaar Ragab56Maria Cristina Maggio57Joanna Makowska58Emanuela Del Giudice59Armin Maier60Sukran Erten61Henrique A Mayrink Giardini62Maria Morrone63Isabele Parente de Brito Antonelli64Marilia Ambiel Dagostin65Martina Patrone66Fehaid Alanazi67Carla Gaggiano68Hamit Kucuk69Ayman Abdel-Monem Ahmed Mahmoud70Katerina Kourtesi71Maria Tarsia72Verónica Gómez-Caverzaschi73Angela Mauro74Alberto Balistreri75Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Brescia, Brescia, ItalyRheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna - Ferrara, University of Ferrara, Ferrara, ItalyAcademic Rheumatology Centre, Ospedale Mauriziano - Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino, Turin, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, ItalyRheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDivision of Immunology, Transplants and Infectious Diseases, Università Vita-Salute San Raffaele, Milan, ItalyRheumatology Department, Istituto di ricovero e cura a carattere scientifico Policlinico S. Matteo Fondazione, University of Pavia, Pavia, ItalyCardiovascular Risk Research Laboratory, First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens School of Medicine, Athens, GreeceDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, MexicoRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L`Aquila, L`Aquila, ItalyRheumatology and Clinical Immunology, Department of Medicine, University of Rome “Campus Biomedico”, School of Medicine, Rome, ItalyUOC Reumatologia, Azienda Ospedaliero-Universitaria Senese, ERN-RITA Center, Siena, ItalyRheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, ItalyUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Life, Health & Environmental Sciences and Internal Medicine and Nephrology Unit, Department of Medicine, University of L`Aquila and ASL Avezzano-Sulmona-L`Aquila, San Salvatore Hospital, L`Aquila, ItalyDepartment of Woman, Child and of General and Specialized Surgery, University of Campania Luigi Vanvitelli, Napoli, ItalyUOC Reumatologia, Azienda Ospedaliero-Universitaria Senese, ERN-RITA Center, Siena, ItalyRheumatology Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyDepartment of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, TurkeyDepartment of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, TurkeyCardiovascular Risk Research Laboratory, First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens School of Medicine, Athens, GreeceDepartment of Experimental and Clinical Medicine, University of Florence, Florence, ItalyOphthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Siena, ItalyNEUROFARBA Department, Rheumatology Unit, Meyer Children`s University Hospital, University of Florence, Firenze, ItalyDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, ItalyDepartment of Medicine and Surgery, MED/16- Rheumatology, Università degli studi di Perugia, P.zza Università, Perugia, ItalyDivision of Immunology, Transplants and Infectious Diseases, Università Vita-Salute San Raffaele, Milan, ItalyDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, ItalyDepartment of Internal Medicine, Division of Rheumatology, Gazi University, Ankara, TurkeyUOC Reumatologia, Azienda Ospedaliero-Universitaria Senese, ERN-RITA Center, Siena, ItalyAntwerp Unit for Data Analysis and Computation in Immunology and Sequencing, University of Antwerp, Antwerp, BelgiumDepartment of Translational Medical Sciences, Section of Clinical Immunology, University of Naples Federico II, Napoli, ItalyRheumatology and Clinical Immunology, Department of Medicine, University of Rome “Campus Biomedico”, School of Medicine, Rome, ItalyU.O.Medicina Generale, Ospedale San Paolo di Civitavecchia, ASL Roma 4, Civitavecchia, Rome, ItalyRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L`Aquila, L`Aquila, ItalyJoint Academic Rheumatology Program, First Department of Propaedeutic and Internal Medicine, National and Kapodistrian University of Athens, Athens, GreeceCenter of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDivision of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, University of Milan, Milano, ItalyVasculitis Research Unit and Autoinflammatory Diseases Clinical Unit, Department of Autoimmune Diseases, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Barcelona, SpainThird Department of Paediatrics, National and Kapodistrian University of Athens, General University Hospital Attikon, Athens, GreeceDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet`s Disease Clinic, University of Siena, Siena, ItalyDepartment of Biomedical and Clinical Sciences Luigi Sacco, Luigi Sacco Hospital, University of Milan, Milan, ItalyDepartment of Internal Medicine, Pneumonology, Allergology and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Poland Ministry of Interior and Administration, Warszawa, PolandUOC di Reumatologia, Azienda Ospedaliera San Camillo Forlanini, Roma, ItalyDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, MexicoRheumatology Unit, Department of Medicine (DIMED), University of Padova, Padova, ItalyPediatric Nephrology and Rheumatology Unit, Azienda Ospedaliera Universitaria (AOU), G. Martino, Messina, ItalyRheumatology and Clinical Immunology, Department of Medicine, University of Rome “Campus Biomedico”, School of Medicine, Rome, ItalyClinical Pediatrics, University of Bari, Bari, ItalyRheumatology and Immunology Unit, Internal Medicine Department, Mansoura University, Mansoura, EgyptDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, MexicoUOSD Reumatologia ARNAS Garibaldi, Catania, ItalyUOC Reumatologia, Azienda Ospedaliero-Universitaria Senese, ERN-RITA Center, Siena, ItalyRheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi ArabiaRheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi ArabiaInternal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Giza, EgyptUniversity Department Pro.Sa.M.I. G. D`Alessandro, University of Palermo, Palermo, ItalyDepartment of Rheumatology, Medical University of Lodz, Łódź, PolandPediatric and Neonatology Unit, Department of Maternal Infantile and Urological Sciences, Sapienza, University of Rome, Polo Pontino, Latina, ItalyRheumatology Unit, Department of Medicine, Central Hospital of Bolzano, Bolzano, ItalyDepartment of Rheumatology, Faculty of Medicine Ankara City Hospital, Ankara Yıldırım Beyazıt University, Ankara, TurkeyRheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de Sao Paulo, Sao Paulo, BrazilDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, ItalyRheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de Sao Paulo, Sao Paulo, BrazilRheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de Sao Paulo, Sao Paulo, BrazilDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Napoli, ItalyRheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi ArabiaDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet`s Disease Clinic, University of Siena, Siena, ItalyDepartment of Internal Medicine, Division of Rheumatology, Gazi University, Ankara, TurkeyInternal Medicine Department, Rheumatology and Clinical Immunology Unit, Cairo University, Giza, EgyptDepartment of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, GreeceAzienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Azienda Ospedaliero-Universitaria Senese, Siena, ItalyDepartment of Autoimmune Diseases, Institut d`Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic of Barcelona [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Barcelona, Barcelona, SpainPediatric Unit, Fatebenefratelli Hospital, Milan, MilanBioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, Siena, ItalyObjective Still’s disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still’s disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still’s disease.Methods Subjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still’s disease.Results A total of 411 patients suffering from Still’s disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still’s disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p<0.0001) were significantly more frequent among elderly-onset patients compared with paediatric-onset subjects. Regarding laboratory data, thrombocytosis was significantly more frequent among paediatric patients onset compared with adult-onset subjects (p<0.0001), while thrombocytopenia was more frequent among elderly-onset patients although statistical significance was only bordered. No substantial differences were observed in the response to treatments.Conclusions Despite some minor difference between groups, overall, demographic, clinical, laboratory and treatments aspects of Still’s disease were similarly observed in patients at all ages. This supports that pediatric-onset, adult-onset and elderly-onset Still’s disease is the same clinical condition arising in different ages.https://rmdopen.bmj.com/content/9/4/e003578.full |
| spellingShingle | Micol Frassi Marcello Govoni Annamaria Iagnocco Florenzo Iannone Paola Triggianese Corrado Campochiaro Sara Monti Maria G Tektonidou Eduardo Martin-Nares Piero Ruscitti Roberto Giacomelli Luca Cantarini Giuseppe Lopalco Lorenzo Dagna Francesco Carubbi Alma Nunzia Olivieri Antonio Vitale Ombretta Viapiana Fatma Alibaz-Öner Haner Direskeneli Petros P Sfikakis Giacomo Emmi Claudia Fabiani Gabriele Simonini Francesco Ciccia Elena Bartoloni Alessandro Tomelleri Daniela Iacono Riza Can Kardas Bruno Frediani Benson Ogunjimi Amato de Paulis Onorina Berardicurti Alessandro Conforti Ilenia Di Cola Anastasios Karamanakos Katerina Laskari Abdurrahman Tufan Stefania Costi José Hernández-Rodríguez Lampros Fotis Jurgen Sota Antonio Gidaro Ewa Wiesik-Szewczyk Gian Domenico Sebastiani Jiram Torres-Ruiz Paolo Sfriso Giovanni Conti Luca Navarini Francesco La Torre Samar Tharwat Andrea Hinojosa-Azaola Alberto Lo Gullo Valeria Caggiano Ibrahim A Almaghlouth Kazi Asfina Gafaar Ragab Maria Cristina Maggio Joanna Makowska Emanuela Del Giudice Armin Maier Sukran Erten Henrique A Mayrink Giardini Maria Morrone Isabele Parente de Brito Antonelli Marilia Ambiel Dagostin Martina Patrone Fehaid Alanazi Carla Gaggiano Hamit Kucuk Ayman Abdel-Monem Ahmed Mahmoud Katerina Kourtesi Maria Tarsia Verónica Gómez-Caverzaschi Angela Mauro Alberto Balistreri Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry RMD Open |
| title | Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry |
| title_full | Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry |
| title_fullStr | Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry |
| title_full_unstemmed | Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry |
| title_short | Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry |
| title_sort | still s disease continuum from childhood to elderly data from the international aida network still s disease registry |
| url | https://rmdopen.bmj.com/content/9/4/e003578.full |
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stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT mariliaambieldagostin stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT martinapatrone stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT fehaidalanazi stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT carlagaggiano stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT hamitkucuk stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT aymanabdelmonemahmedmahmoud stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT katerinakourtesi stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT mariatarsia stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT veronicagomezcaverzaschi stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT angelamauro stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry AT albertobalistreri stillsdiseasecontinuumfromchildhoodtoelderlydatafromtheinternationalaidanetworkstillsdiseaseregistry |