T2Candida Assay in the Diagnosis of Intraabdominal Candidiasis: A Prospective Multicenter Study
The T2Candida magnetic resonance assay is a direct-from-blood pathogen detection assay that delivers a result within 3–5 h, targeting the most clinically relevant <i>Candida</i> species. Between February 2019 and March 2021, the study included consecutive patients aged >18 years admit...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/1/86 |
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| author | Anders Krifors Måns Ullberg Markus Castegren Johan Petersson Ernesto Sparrelid Helena Hammarström Jan Sjölin Volkan Özenci Ola Blennow |
| author_facet | Anders Krifors Måns Ullberg Markus Castegren Johan Petersson Ernesto Sparrelid Helena Hammarström Jan Sjölin Volkan Özenci Ola Blennow |
| author_sort | Anders Krifors |
| collection | DOAJ |
| description | The T2Candida magnetic resonance assay is a direct-from-blood pathogen detection assay that delivers a result within 3–5 h, targeting the most clinically relevant <i>Candida</i> species. Between February 2019 and March 2021, the study included consecutive patients aged >18 years admitted to an intensive care unit or surgical high-dependency unit due to gastrointestinal surgery or necrotizing pancreatitis and from whom diagnostic blood cultures were obtained. Blood samples were tested in parallel with T2Candida and 1,3-β-D-glucan. Of 134 evaluable patients, 13 (10%) were classified as having proven intraabdominal candidiasis (IAC) according to the EORTC/MSG criteria. Two of the thirteen patients (15%) had concurrent candidemia. The sensitivity, specificity, positive predictive value, and negative predictive value, respectively, were 46%, 97%, 61%, and 94% for T2Candida and 85%, 83%, 36%, and 98% for 1,3-β-D-glucan. All positive T2Candida results were consistent with the culture results at the species level, except for one case of dual infection. The performance of T2Candida was comparable with that of 1,3-β-D-glucan for candidemic IAC but had a lower sensitivity for non-candidemic IAC (36% vs. 82%). In conclusion, T2Candida may be a valuable complement to 1,3-β-D-glucan in the clinical management of high-risk surgical patients because of its rapid results and ease of use. |
| first_indexed | 2024-03-10T01:09:57Z |
| format | Article |
| id | doaj.art-0dea03a62bec4e2d9d3e088ec6c26fe1 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T01:09:57Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-0dea03a62bec4e2d9d3e088ec6c26fe12023-11-23T14:18:48ZengMDPI AGJournal of Fungi2309-608X2022-01-01818610.3390/jof8010086T2Candida Assay in the Diagnosis of Intraabdominal Candidiasis: A Prospective Multicenter StudyAnders Krifors0Måns Ullberg1Markus Castegren2Johan Petersson3Ernesto Sparrelid4Helena Hammarström5Jan Sjölin6Volkan Özenci7Ola Blennow8Department of Physiology and Pharmacology, Karolinska Institutet, 171 65 Stockholm, SwedenDepartment of Clinical Microbiology, Karolinska University Hospital, 171 76 Stockholm, SwedenDepartment of Physiology and Pharmacology, Karolinska Institutet, 171 65 Stockholm, SwedenDepartment of Physiology and Pharmacology, Karolinska Institutet, 171 65 Stockholm, SwedenDepartment of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Karolinska University Hospital, 141 52 Stockholm, SwedenDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 402 34 Gothenburg, SwedenDepartment of Medical Sciences, Section of Infectious Diseases, Uppsala University, 751 85 Uppsala, SwedenDepartment of Clinical Microbiology, Karolinska University Hospital, 171 76 Stockholm, SwedenDepartment of Infectious Diseases, Karolinska University Hospital, 171 76 Stockholm, SwedenThe T2Candida magnetic resonance assay is a direct-from-blood pathogen detection assay that delivers a result within 3–5 h, targeting the most clinically relevant <i>Candida</i> species. Between February 2019 and March 2021, the study included consecutive patients aged >18 years admitted to an intensive care unit or surgical high-dependency unit due to gastrointestinal surgery or necrotizing pancreatitis and from whom diagnostic blood cultures were obtained. Blood samples were tested in parallel with T2Candida and 1,3-β-D-glucan. Of 134 evaluable patients, 13 (10%) were classified as having proven intraabdominal candidiasis (IAC) according to the EORTC/MSG criteria. Two of the thirteen patients (15%) had concurrent candidemia. The sensitivity, specificity, positive predictive value, and negative predictive value, respectively, were 46%, 97%, 61%, and 94% for T2Candida and 85%, 83%, 36%, and 98% for 1,3-β-D-glucan. All positive T2Candida results were consistent with the culture results at the species level, except for one case of dual infection. The performance of T2Candida was comparable with that of 1,3-β-D-glucan for candidemic IAC but had a lower sensitivity for non-candidemic IAC (36% vs. 82%). In conclusion, T2Candida may be a valuable complement to 1,3-β-D-glucan in the clinical management of high-risk surgical patients because of its rapid results and ease of use.https://www.mdpi.com/2309-608X/8/1/86T2 magnetic resonancebeta-glucanblood culturesintraabdominal candidiasisinvasive candidiasis |
| spellingShingle | Anders Krifors Måns Ullberg Markus Castegren Johan Petersson Ernesto Sparrelid Helena Hammarström Jan Sjölin Volkan Özenci Ola Blennow T2Candida Assay in the Diagnosis of Intraabdominal Candidiasis: A Prospective Multicenter Study Journal of Fungi T2 magnetic resonance beta-glucan blood cultures intraabdominal candidiasis invasive candidiasis |
| title | T2Candida Assay in the Diagnosis of Intraabdominal Candidiasis: A Prospective Multicenter Study |
| title_full | T2Candida Assay in the Diagnosis of Intraabdominal Candidiasis: A Prospective Multicenter Study |
| title_fullStr | T2Candida Assay in the Diagnosis of Intraabdominal Candidiasis: A Prospective Multicenter Study |
| title_full_unstemmed | T2Candida Assay in the Diagnosis of Intraabdominal Candidiasis: A Prospective Multicenter Study |
| title_short | T2Candida Assay in the Diagnosis of Intraabdominal Candidiasis: A Prospective Multicenter Study |
| title_sort | t2candida assay in the diagnosis of intraabdominal candidiasis a prospective multicenter study |
| topic | T2 magnetic resonance beta-glucan blood cultures intraabdominal candidiasis invasive candidiasis |
| url | https://www.mdpi.com/2309-608X/8/1/86 |
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