HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS
In the present study we characterized the effect of transplantation of bone marrow and adipose tissue MSCs in the model of brain injury in rats. This study was performed on Wistar rats (males and females in equal proportions with body weight of 250—270 g; n = 50). Traumatic brain injury was produced...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2012-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/939 |
| _version_ | 1797237663873368064 |
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| author | E. V. Polovnikov V. V. Stupak A. G. Samokhin I. A. Vasiliev O. B. Dobryakova E. Ya. Shevela E. R. Chernykh |
| author_facet | E. V. Polovnikov V. V. Stupak A. G. Samokhin I. A. Vasiliev O. B. Dobryakova E. Ya. Shevela E. R. Chernykh |
| author_sort | E. V. Polovnikov |
| collection | DOAJ |
| description | In the present study we characterized the effect of transplantation of bone marrow and adipose tissue MSCs in the model of brain injury in rats. This study was performed on Wistar rats (males and females in equal proportions with body weight of 250—270 g; n = 50). Traumatic brain injury was produced, by original spring-loaded, mechanism to precise dosing of impact force. Neurological disorders were assessed by Chen scale, a vertical grid test and a Morris water maze. MSC injections on day 1 were accompanied by a significant reduction in neurological deficit in compare with the control group. Adipose tissue derived MSCs were found to have a more pronounced effectiveness than MSCs obtained from bone marrow. |
| first_indexed | 2024-03-08T12:22:46Z |
| format | Article |
| id | doaj.art-0dea75fb9b2146e183db58a1c05ba018 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:23:20Z |
| publishDate | 2012-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-0dea75fb9b2146e183db58a1c05ba0182024-03-28T07:49:04ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)301304885HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATSE. V. Polovnikov0V. V. Stupak1A. G. Samokhin2I. A. Vasiliev3O. B. Dobryakova4E. Ya. Shevela5E. R. Chernykh6Research Institute of Traumatology and OrthopedicsResearch Institute of Traumatology and OrthopedicsResearch Institute of Traumatology and OrthopedicsResearch Institute of Traumatology and OrthopedicsResearch Institute of Traumatology and OrthopedicsResearch Institute of Clinical Immunology SB RAMSResearch Institute of Clinical Immunology SB RAMSIn the present study we characterized the effect of transplantation of bone marrow and adipose tissue MSCs in the model of brain injury in rats. This study was performed on Wistar rats (males and females in equal proportions with body weight of 250—270 g; n = 50). Traumatic brain injury was produced, by original spring-loaded, mechanism to precise dosing of impact force. Neurological disorders were assessed by Chen scale, a vertical grid test and a Morris water maze. MSC injections on day 1 were accompanied by a significant reduction in neurological deficit in compare with the control group. Adipose tissue derived MSCs were found to have a more pronounced effectiveness than MSCs obtained from bone marrow.https://www.actabiomedica.ru/jour/article/view/939controlled cortical injury modelneurological deficitmesenchymal stem marrowadipose cells |
| spellingShingle | E. V. Polovnikov V. V. Stupak A. G. Samokhin I. A. Vasiliev O. B. Dobryakova E. Ya. Shevela E. R. Chernykh HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS Acta Biomedica Scientifica controlled cortical injury model neurological deficit mesenchymal stem marrow adipose cells |
| title | HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS |
| title_full | HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS |
| title_fullStr | HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS |
| title_full_unstemmed | HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS |
| title_short | HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS |
| title_sort | human bone marrow and adipose tissue derived mesenchymal stromal cell influence on neurological deficit recovery in a model of severe traumatic brain injury in rats |
| topic | controlled cortical injury model neurological deficit mesenchymal stem marrow adipose cells |
| url | https://www.actabiomedica.ru/jour/article/view/939 |
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