Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons
Neurons are extremely polarized structures with long axons and dendrites, which require proper distribution of mitochondria and maintenance of mitochondrial dynamics for neuronal functions and survival. Indeed, recent studies show that various neurological disorders are linked to mitochondrial tran...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-09-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00148/full |
| _version_ | 1818154950921814016 |
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| author | Robert eNiescier Karen eChang Kyung-Tai eMin |
| author_facet | Robert eNiescier Karen eChang Kyung-Tai eMin |
| author_sort | Robert eNiescier |
| collection | DOAJ |
| description | Neurons are extremely polarized structures with long axons and dendrites, which require proper distribution of mitochondria and maintenance of mitochondrial dynamics for neuronal functions and survival. Indeed, recent studies show that various neurological disorders are linked to mitochondrial transport in neurons. Mitochondrial anterograde transport is believed to deliver metabolic energy to synaptic terminals where energy demands are high, while mitochondrial retrograde transport is required to repair or remove damaged mitochondria in axons. It has been suggested that Ca2+ plays a key role in regulating mitochondrial transport by altering the configuration of mitochondrial protein, miro. However, molecular mechanisms that regulate mitochondrial transport in neurons still are not well characterized. In this review, we will discuss the roles of miro in mitochondrial transport and how the recently identified components of the mitochondrial calcium uniporter add to our current model of mitochondrial mobility regulation. |
| first_indexed | 2024-12-11T14:34:39Z |
| format | Article |
| id | doaj.art-0debfef4d44a44cdab77a113717ab752 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T14:34:39Z |
| publishDate | 2013-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-0debfef4d44a44cdab77a113717ab7522022-12-22T01:02:13ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022013-09-01710.3389/fncel.2013.0014860842Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axonsRobert eNiescier0Karen eChang1Kyung-Tai eMin2Ulsan National Institute of Science and TechnologyUniversity of Southern CaliforniaUlsan National Institute of Science and TechnologyNeurons are extremely polarized structures with long axons and dendrites, which require proper distribution of mitochondria and maintenance of mitochondrial dynamics for neuronal functions and survival. Indeed, recent studies show that various neurological disorders are linked to mitochondrial transport in neurons. Mitochondrial anterograde transport is believed to deliver metabolic energy to synaptic terminals where energy demands are high, while mitochondrial retrograde transport is required to repair or remove damaged mitochondria in axons. It has been suggested that Ca2+ plays a key role in regulating mitochondrial transport by altering the configuration of mitochondrial protein, miro. However, molecular mechanisms that regulate mitochondrial transport in neurons still are not well characterized. In this review, we will discuss the roles of miro in mitochondrial transport and how the recently identified components of the mitochondrial calcium uniporter add to our current model of mitochondrial mobility regulation.http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00148/fullAxonal TransportMitochondriaMCUMICU1miro |
| spellingShingle | Robert eNiescier Karen eChang Kyung-Tai eMin Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons Frontiers in Cellular Neuroscience Axonal Transport Mitochondria MCU MICU1 miro |
| title | Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
| title_full | Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
| title_fullStr | Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
| title_full_unstemmed | Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
| title_short | Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
| title_sort | miro mcu and calcium bridging our understanding of mitochondrial movement in axons |
| topic | Axonal Transport Mitochondria MCU MICU1 miro |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00148/full |
| work_keys_str_mv | AT roberteniescier miromcuandcalciumbridgingourunderstandingofmitochondrialmovementinaxons AT karenechang miromcuandcalciumbridgingourunderstandingofmitochondrialmovementinaxons AT kyungtaiemin miromcuandcalciumbridgingourunderstandingofmitochondrialmovementinaxons |