Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy
Abstract Owing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nano...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-02-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-020-00754-8 |
| _version_ | 1811186859471011840 |
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| author | Beilei Gong Yuanbing Shen Huiyan Li Xiaojun Li Xia Huan Jihong Zhou Yuqing Chen Jian Wu Wei Li |
| author_facet | Beilei Gong Yuanbing Shen Huiyan Li Xiaojun Li Xia Huan Jihong Zhou Yuqing Chen Jian Wu Wei Li |
| author_sort | Beilei Gong |
| collection | DOAJ |
| description | Abstract Owing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanine green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhance the photodynamic/photothermal combination therapy (PDT/PTT). In addition to the significantly increased payload and enhancing photostability of ICG, the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy. |
| first_indexed | 2024-04-11T13:52:21Z |
| format | Article |
| id | doaj.art-0dec571e507249e6bc43365676f4e058 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T13:52:21Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-0dec571e507249e6bc43365676f4e0582022-12-22T04:20:29ZengBMCJournal of Nanobiotechnology1477-31552021-02-0119111410.1186/s12951-020-00754-8Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapyBeilei Gong0Yuanbing Shen1Huiyan Li2Xiaojun Li3Xia Huan4Jihong Zhou5Yuqing Chen6Jian Wu7Wei Li8Department of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical CollegeDepartment of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical CollegeDepartment of Medical Microbiology, MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan UniversityDepartment of Thoracic Surgery, the First Affiliated Hospital of Bengbu Medical CollegeDepartment of Respiratory Disease, People’s Hospital of ShannanAnhui Province Key Laboratory of Translational Cancer ResearchDepartment of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical CollegeDepartment of Medical Microbiology, MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan UniversityDepartment of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical CollegeAbstract Owing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanine green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhance the photodynamic/photothermal combination therapy (PDT/PTT). In addition to the significantly increased payload and enhancing photostability of ICG, the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy.https://doi.org/10.1186/s12951-020-00754-8Gold nanorodsThermoresponsivePhotodynamic therapyPhotothermal therapy |
| spellingShingle | Beilei Gong Yuanbing Shen Huiyan Li Xiaojun Li Xia Huan Jihong Zhou Yuqing Chen Jian Wu Wei Li Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy Journal of Nanobiotechnology Gold nanorods Thermoresponsive Photodynamic therapy Photothermal therapy |
| title | Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy |
| title_full | Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy |
| title_fullStr | Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy |
| title_full_unstemmed | Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy |
| title_short | Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy |
| title_sort | thermo responsive polymer encapsulated gold nanorods for single continuous wave laser induced photodynamic photothermal tumour therapy |
| topic | Gold nanorods Thermoresponsive Photodynamic therapy Photothermal therapy |
| url | https://doi.org/10.1186/s12951-020-00754-8 |
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