STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY?
<p>Results of combined therapy of gallstone disease (GSD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and hypercholesterolemia (HCE) with statins and ursodeoxycholic acid (UDCA) are analyzed. In GSD statin therapy was often accompanied with reduction of bil...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | http://www.rpcardio.ru/jour/article/view/736 |
| _version_ | 1797712310021652480 |
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| author | I. N. Grigorieva Y. M. Pozdnyakov |
| author_facet | I. N. Grigorieva Y. M. Pozdnyakov |
| author_sort | I. N. Grigorieva |
| collection | DOAJ |
| description | <p>Results of combined therapy of gallstone disease (GSD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and hypercholesterolemia (HCE) with statins and ursodeoxycholic acid (UDCA) are analyzed. In GSD statin therapy was often accompanied with reduction of bile lithogenicity but did not always accelerate stone litholysis under their combination with UDCA. Statin induced liver injuries are often observed in NAFLD and NASH, adjuvant UDCA therapy shown positive effect on inflammatory and histological liver parameters in these diseases. Serum lipid levels in patients with HCE were reduced most effectively with statin combined with UDCA. Combined therapy with statin and UDCA is recommended in patient with HCE and chronic liver diseases.</p> |
| first_indexed | 2024-03-12T07:19:50Z |
| format | Article |
| id | doaj.art-0defd67051ff4d2683d99a106c112162 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-12T07:19:50Z |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-0defd67051ff4d2683d99a106c1121622023-09-02T22:33:19ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0156515410.1234/1819-6446-2009-6-51-54735STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY?I. N. Grigorieva0Y. M. Pozdnyakov1Научно-исследовательский институт терапии Сибирского отделения РАМН, Новосибирский государственный медицинский университетМосковский областной кардиологический центр<p>Results of combined therapy of gallstone disease (GSD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and hypercholesterolemia (HCE) with statins and ursodeoxycholic acid (UDCA) are analyzed. In GSD statin therapy was often accompanied with reduction of bile lithogenicity but did not always accelerate stone litholysis under their combination with UDCA. Statin induced liver injuries are often observed in NAFLD and NASH, adjuvant UDCA therapy shown positive effect on inflammatory and histological liver parameters in these diseases. Serum lipid levels in patients with HCE were reduced most effectively with statin combined with UDCA. Combined therapy with statin and UDCA is recommended in patient with HCE and chronic liver diseases.</p>http://www.rpcardio.ru/jour/article/view/736статиныурсодезоксихолевая кислотажелчнокаменная болезньнеалкогольная жировая болезнь печенинеалкогольный стеатогепатитгиперхолестеринемия |
| spellingShingle | I. N. Grigorieva Y. M. Pozdnyakov STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY? Рациональная фармакотерапия в кардиологии статины урсодезоксихолевая кислота желчнокаменная болезнь неалкогольная жировая болезнь печени неалкогольный стеатогепатит гиперхолестеринемия |
| title | STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY? |
| title_full | STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY? |
| title_fullStr | STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY? |
| title_full_unstemmed | STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY? |
| title_short | STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY? |
| title_sort | statins and ursodeoxycholic acid cooperation or neutrality |
| topic | статины урсодезоксихолевая кислота желчнокаменная болезнь неалкогольная жировая болезнь печени неалкогольный стеатогепатит гиперхолестеринемия |
| url | http://www.rpcardio.ru/jour/article/view/736 |
| work_keys_str_mv | AT ingrigorieva statinsandursodeoxycholicacidcooperationorneutrality AT ympozdnyakov statinsandursodeoxycholicacidcooperationorneutrality |