Neuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study
Here, a study of NMOSD in Central America and the Caribbean with a multinational collaborative, multicentric and descriptive approach involving 25 institutions from 9 countries is presented. Demographics, clinical manifestations, expanded disability scale status (EDSS), brain and spinal cord MRI, se...
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MDPI AG
2022-03-01
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| Series: | Neurology International |
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| Online Access: | https://www.mdpi.com/2035-8377/14/1/23 |
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| author | Fernando Gracia Deyanira Ramírez Alexander Parajeles-Vindas Alejandro Díaz Amado Díaz de la Fé Nicia Eunice Ramírez Sánchez Romy Castro Escobar Luis Alberto García Valle Roberto Weiser Biany Santos Awilda Candelario Aron Benzadon Pahola Araujo Carlos Valderrama Mario Larreategui Gabriela Carrillo Karla Gracia Johana Vázquez-Céspedes Priscilla Monterrey-Alvarez Kenneth Carazo-Céspedes Alfredo Sanabria-Castro Gustavo Miranda-Loria Andrea Balmaceda-Meza Ligia Ibeth Portillo Rivera Irma Olivera Leal Luis Cesar Rodriguez Salinas Arnold Thompson Ericka López Torres Daniel Enrique Pereira Carolina Zepeda César Abdón López Ernesto Arturo Cornejo Valse Karla Zinica Corea Urbina Marco Antonio Urrutia Ivonne Van Sijtveld Blas Armien Victor M. Rivera |
| author_facet | Fernando Gracia Deyanira Ramírez Alexander Parajeles-Vindas Alejandro Díaz Amado Díaz de la Fé Nicia Eunice Ramírez Sánchez Romy Castro Escobar Luis Alberto García Valle Roberto Weiser Biany Santos Awilda Candelario Aron Benzadon Pahola Araujo Carlos Valderrama Mario Larreategui Gabriela Carrillo Karla Gracia Johana Vázquez-Céspedes Priscilla Monterrey-Alvarez Kenneth Carazo-Céspedes Alfredo Sanabria-Castro Gustavo Miranda-Loria Andrea Balmaceda-Meza Ligia Ibeth Portillo Rivera Irma Olivera Leal Luis Cesar Rodriguez Salinas Arnold Thompson Ericka López Torres Daniel Enrique Pereira Carolina Zepeda César Abdón López Ernesto Arturo Cornejo Valse Karla Zinica Corea Urbina Marco Antonio Urrutia Ivonne Van Sijtveld Blas Armien Victor M. Rivera |
| author_sort | Fernando Gracia |
| collection | DOAJ |
| description | Here, a study of NMOSD in Central America and the Caribbean with a multinational collaborative, multicentric and descriptive approach involving 25 institutions from 9 countries is presented. Demographics, clinical manifestations, expanded disability scale status (EDSS), brain and spinal cord MRI, serological anti-AQP4-IgG and anti-MOG-IgG antibodies, and cerebrospinal fluid (CSF) oligoclonal bands were included. A central serological repository utilized the cell-based assay. The specimens outside of this network employed diverse methodologies. Data were collected at the Gorgas Commemorative Institute of Health Studies (ICGES), Panama, and included 186 subjects, of which 84% were females (sex ratio of 5.6:1). Mestizos constituted 72% of the study group. The median age was 42.5 years (IQR: 32.0–52.0). Associated autoimmune diseases (8.1%) were myasthenia gravis, Sjögren’s syndrome and systemic lupus erythematosus. The most common manifestation was optic neuritis-transverse myelitis (42.5%). A relapsing course was described in 72.3% of cases. EDSS scores of 0–3.5 were reported in 57.2% of cases and higher than 7.0 in 14.5%. Positive anti-AQP4-IgG antibody occurred in 59.8% and anti-MOG-IgG antibody in 11.5% of individuals. Antibody testing was lacking for 13.4% of patients. The estimated crude prevalence of NMOSD from Panama and the Dominican Republic was 1.62/100,000 (incidence of 0.08–0.41) and 0.73/100,000 (incidence 0.02–0.14), respectively. This multinational study contributes additional insights and data on the understanding of NMOSD in this Latin American region. |
| first_indexed | 2024-03-09T13:06:18Z |
| format | Article |
| id | doaj.art-0df03924ea45445587d9333661897939 |
| institution | Directory Open Access Journal |
| issn | 2035-8377 |
| language | English |
| last_indexed | 2024-03-09T13:06:18Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-0df03924ea45445587d93336618979392023-11-30T21:47:45ZengMDPI AGNeurology International2035-83772022-03-0114128429310.3390/neurolint14010023Neuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization StudyFernando Gracia0Deyanira Ramírez1Alexander Parajeles-Vindas2Alejandro Díaz3Amado Díaz de la Fé4Nicia Eunice Ramírez Sánchez5Romy Castro Escobar6Luis Alberto García Valle7Roberto Weiser8Biany Santos9Awilda Candelario10Aron Benzadon11Pahola Araujo12Carlos Valderrama13Mario Larreategui14Gabriela Carrillo15Karla Gracia16Johana Vázquez-Céspedes17Priscilla Monterrey-Alvarez18Kenneth Carazo-Céspedes19Alfredo Sanabria-Castro20Gustavo Miranda-Loria21Andrea Balmaceda-Meza22Ligia Ibeth Portillo Rivera23Irma Olivera Leal24Luis Cesar Rodriguez Salinas25Arnold Thompson26Ericka López Torres27Daniel Enrique Pereira28Carolina Zepeda29César Abdón López30Ernesto Arturo Cornejo Valse31Karla Zinica Corea Urbina32Marco Antonio Urrutia33Ivonne Van Sijtveld34Blas Armien35Victor M. Rivera36Neurology Service, Hospital Santo Tomás, Panama City 0819-03752, PanamaNeurology Service, Hospital Docente Padre Billini, Santo Domingo City 11102, Dominican RepublicNeurology Service, Hospital San Juan de Dios CCSS, San Jose 1475-1000, Costa RicaNeurology Service, Instituto Guatemalteco de Seguridad Social, Guatemala City 1010, GuatemalaNeurology Service, Centro Internacional de Restauración Neurológica (CIREN), La Habana 11300, CubaNeurology Service, Hospital Dr. Mario Catarino Rivas, San Pedro Sula 21104, HondurasNeurology Service, Instituto Salvadoreño del Seguro Social, San Salvador 1101, El SalvadorNeurology Service, Hospital Militar Escuela Dr. Alejandro Dávila Bolaños, Managua 14285, NicaraguaNeurology Service, Hospital Horacio Oduber, Oranjestad 569, ArubaNeurology Service, Hospital Cabral y Baez, Santiago City 10206, Dominican RepublicNeurology Service, Hospital Docente Padre Billini, Santo Domingo City 11102, Dominican RepublicNeurology Service, Complejo Hospitalario Dr. Arnulfo Arias Madrid CSS, Panama City 0831-01654, PanamaNeurology Service, Complejo Hospitalario Dr. Arnulfo Arias Madrid CSS, Panama City 0831-01654, PanamaNeurology Service, Hospital Regional Rafael Hernández CSS, David City 0816-06808, PanamaNeurology Service, Hospital Regional Anita Moreno MINSA, La Villa de Los Santos 0819-11380, PanamaNeurology Service, Hospital Santo Tomás, Panama City 0819-03752, PanamaSchool of Medicine, Universidad Interamericana de Panamá, Panama City 0830-00929, PanamaNeurology Service, Hospital San Juan de Dios CCSS, San Jose 1475-1000, Costa RicaNeurology Service, Hospital San Rafael de Alajuela CCSS, Alajuela 1481-2100, Costa RicaNeurology Service, Hospital San Juan de Dios CCSS, San Jose 1475-1000, Costa RicaNeurology Service, Hospital San Juan de Dios CCSS, San Jose 1475-1000, Costa RicaNeurology Service, Hospital San Rafael de Alajuela CCSS, Alajuela 1481-2100, Costa RicaNeurology Service, Centro de Desarrollo Estratégico e Información de Salud y Seguridad Social (CENDEISSSS CCSS), San Jose 1475-1000, Costa RicaNeurology Service, Hospital General de Enfermedades (IGSS), Guatemala City 1015, GuatemalaNeurology Service, Hospital Hermanos Almejeira, La Habana 10200, CubaNeurology Service, Instituto Hondureño de Seguridad Social, Tegucigalpa 11101, HondurasNeurology Service, Hospital Dr. Mario Catarino Rivas, San Pedro Sula 21104, HondurasNeurology Service, Hospital Nacional Rosales, San Salvador 1101, El SalvadorNeurology Service, Instituto Salvadoreño del Seguro Social, San Salvador 1101, El SalvadorNeurology Service, Hospital Nacional Rosales, San Salvador 1101, El SalvadorNeurology Service, Hospital Nacional Rosales, San Salvador 1101, El SalvadorNeurology Service, Instituto Salvadoreño del Seguro Social, San Salvador 1101, El SalvadorNeurology Service, Hospital Militar Escuela Dr. Alejandro Dávila Bolaños, Managua 14285, NicaraguaNeurology Service, Hospital Infantil de Nicaragua Manuel de Jesús Rivera La Mascota, Managua 12001, NicaraguaNeurology Service, Hospital Horacio Oduber, Oranjestad 569, ArubaDirección de Investigación, Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama City 0816-02593, PanamaNeurology Department, Baylor College of Medicine, Houston, TX 77025, USAHere, a study of NMOSD in Central America and the Caribbean with a multinational collaborative, multicentric and descriptive approach involving 25 institutions from 9 countries is presented. Demographics, clinical manifestations, expanded disability scale status (EDSS), brain and spinal cord MRI, serological anti-AQP4-IgG and anti-MOG-IgG antibodies, and cerebrospinal fluid (CSF) oligoclonal bands were included. A central serological repository utilized the cell-based assay. The specimens outside of this network employed diverse methodologies. Data were collected at the Gorgas Commemorative Institute of Health Studies (ICGES), Panama, and included 186 subjects, of which 84% were females (sex ratio of 5.6:1). Mestizos constituted 72% of the study group. The median age was 42.5 years (IQR: 32.0–52.0). Associated autoimmune diseases (8.1%) were myasthenia gravis, Sjögren’s syndrome and systemic lupus erythematosus. The most common manifestation was optic neuritis-transverse myelitis (42.5%). A relapsing course was described in 72.3% of cases. EDSS scores of 0–3.5 were reported in 57.2% of cases and higher than 7.0 in 14.5%. Positive anti-AQP4-IgG antibody occurred in 59.8% and anti-MOG-IgG antibody in 11.5% of individuals. Antibody testing was lacking for 13.4% of patients. The estimated crude prevalence of NMOSD from Panama and the Dominican Republic was 1.62/100,000 (incidence of 0.08–0.41) and 0.73/100,000 (incidence 0.02–0.14), respectively. This multinational study contributes additional insights and data on the understanding of NMOSD in this Latin American region.https://www.mdpi.com/2035-8377/14/1/23neuromyelitis optica spectrum disorderCentral AmericaCaribbeananti-AQP4-IgG antibodiesanti-MOG-IgG antibodiesclinical characterization |
| spellingShingle | Fernando Gracia Deyanira Ramírez Alexander Parajeles-Vindas Alejandro Díaz Amado Díaz de la Fé Nicia Eunice Ramírez Sánchez Romy Castro Escobar Luis Alberto García Valle Roberto Weiser Biany Santos Awilda Candelario Aron Benzadon Pahola Araujo Carlos Valderrama Mario Larreategui Gabriela Carrillo Karla Gracia Johana Vázquez-Céspedes Priscilla Monterrey-Alvarez Kenneth Carazo-Céspedes Alfredo Sanabria-Castro Gustavo Miranda-Loria Andrea Balmaceda-Meza Ligia Ibeth Portillo Rivera Irma Olivera Leal Luis Cesar Rodriguez Salinas Arnold Thompson Ericka López Torres Daniel Enrique Pereira Carolina Zepeda César Abdón López Ernesto Arturo Cornejo Valse Karla Zinica Corea Urbina Marco Antonio Urrutia Ivonne Van Sijtveld Blas Armien Victor M. Rivera Neuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study Neurology International neuromyelitis optica spectrum disorder Central America Caribbean anti-AQP4-IgG antibodies anti-MOG-IgG antibodies clinical characterization |
| title | Neuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study |
| title_full | Neuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study |
| title_fullStr | Neuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study |
| title_full_unstemmed | Neuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study |
| title_short | Neuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study |
| title_sort | neuromyelitis optica spectrum disorder in central america and the caribbean a multinational clinical characterization study |
| topic | neuromyelitis optica spectrum disorder Central America Caribbean anti-AQP4-IgG antibodies anti-MOG-IgG antibodies clinical characterization |
| url | https://www.mdpi.com/2035-8377/14/1/23 |
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