Clinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions: a retrospective study
Abstract Background Bone marrow lesions (BMLs) are a common finding in patients with osteoarthritis (OA), which are predictors of progression and pain related to cartilage damage in OA. The objective of the present research was to compare the short-term clinical effect of intramuscular calcitonin an...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-020-01746-y |
| _version_ | 1811304642321055744 |
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| author | Jiaming Zhou Wuyi Xiong Pengguo Gou Zhao Chen Xing Guo Xiaoyang Huo Yuan Xue |
| author_facet | Jiaming Zhou Wuyi Xiong Pengguo Gou Zhao Chen Xing Guo Xiaoyang Huo Yuan Xue |
| author_sort | Jiaming Zhou |
| collection | DOAJ |
| description | Abstract Background Bone marrow lesions (BMLs) are a common finding in patients with osteoarthritis (OA), which are predictors of progression and pain related to cartilage damage in OA. The objective of the present research was to compare the short-term clinical effect of intramuscular calcitonin and oral celecoxib in treating knee BMLs. Patients and methods Between January 2016 and December 2018, the medical records of patients with knee BMLs treated by intramuscular calcitonin or oral celecoxib were reviewed. Visual analog scale (VAS) and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) were used to assess knee pain and function, respectively. BMLs were assessed by MRI scans and were scored by the modified Whole-Organ MRI Score (WORMS). The safety of these two medications was also evaluated. Results A total of 123 eligible patients who received calcitonin treatment (n = 66) or celecoxib treatment (n = 57) were included. All patients were followed up clinically and radiographically for 3 months. The VAS and WOMAC scores were lower statistically in calcitonin group than celecoxib group at 4-week and 3-month follow-up. For BMLs, the WORMS scores in the calcitonin group were significantly lower than the celecoxib group. Besides, statistically higher MRI improvement rates were found in the calcitonin group compared with the celecoxib group at 4-week follow-up (21.21% vs. 7.01%; P = 0.039) and 3-month follow-up (37.88% vs. 15.79%; P = 0.006). Conclusion Intramuscular calcitonin 50 IU once daily demonstrated a better short-term effect for knee BML patients compared with oral celecoxib 200 mg twice per day. |
| first_indexed | 2024-04-13T08:10:57Z |
| format | Article |
| id | doaj.art-0df24ecacf03472ebf1507edaf54f15f |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-13T08:10:57Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-0df24ecacf03472ebf1507edaf54f15f2022-12-22T02:54:58ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2020-06-011511810.1186/s13018-020-01746-yClinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions: a retrospective studyJiaming Zhou0Wuyi Xiong1Pengguo Gou2Zhao Chen3Xing Guo4Xiaoyang Huo5Yuan Xue6Department of Orthopaedic Surgery, Tianjin Medical University General HospitalDepartment of Orthopaedic Surgery, Tianjin Medical University General HospitalDepartment of Orthopaedic Surgery, Tianjin Medical University General HospitalDepartment of Orthopaedic Surgery, Tianjin Medical University General HospitalDepartment of Orthopaedic Surgery, Tianjin Medical University General HospitalDepartment of Orthopaedic Surgery, Tianjin Medical University General HospitalDepartment of Orthopaedic Surgery, Tianjin Medical University General HospitalAbstract Background Bone marrow lesions (BMLs) are a common finding in patients with osteoarthritis (OA), which are predictors of progression and pain related to cartilage damage in OA. The objective of the present research was to compare the short-term clinical effect of intramuscular calcitonin and oral celecoxib in treating knee BMLs. Patients and methods Between January 2016 and December 2018, the medical records of patients with knee BMLs treated by intramuscular calcitonin or oral celecoxib were reviewed. Visual analog scale (VAS) and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) were used to assess knee pain and function, respectively. BMLs were assessed by MRI scans and were scored by the modified Whole-Organ MRI Score (WORMS). The safety of these two medications was also evaluated. Results A total of 123 eligible patients who received calcitonin treatment (n = 66) or celecoxib treatment (n = 57) were included. All patients were followed up clinically and radiographically for 3 months. The VAS and WOMAC scores were lower statistically in calcitonin group than celecoxib group at 4-week and 3-month follow-up. For BMLs, the WORMS scores in the calcitonin group were significantly lower than the celecoxib group. Besides, statistically higher MRI improvement rates were found in the calcitonin group compared with the celecoxib group at 4-week follow-up (21.21% vs. 7.01%; P = 0.039) and 3-month follow-up (37.88% vs. 15.79%; P = 0.006). Conclusion Intramuscular calcitonin 50 IU once daily demonstrated a better short-term effect for knee BML patients compared with oral celecoxib 200 mg twice per day.http://link.springer.com/article/10.1186/s13018-020-01746-yCalcitoninCelecoxibBone marrow lesionsOsteoarthritis |
| spellingShingle | Jiaming Zhou Wuyi Xiong Pengguo Gou Zhao Chen Xing Guo Xiaoyang Huo Yuan Xue Clinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions: a retrospective study Journal of Orthopaedic Surgery and Research Calcitonin Celecoxib Bone marrow lesions Osteoarthritis |
| title | Clinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions: a retrospective study |
| title_full | Clinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions: a retrospective study |
| title_fullStr | Clinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions: a retrospective study |
| title_full_unstemmed | Clinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions: a retrospective study |
| title_short | Clinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions: a retrospective study |
| title_sort | clinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions a retrospective study |
| topic | Calcitonin Celecoxib Bone marrow lesions Osteoarthritis |
| url | http://link.springer.com/article/10.1186/s13018-020-01746-y |
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