IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM
Abstract. One hundred and ninety-nine patients with hyperplastic processes of reproductive system were examined, and 131 (66.16%) of them were found to be infected with Chlamydia or Ureaplasma. The mean age of female patients was 42,7±1,35 years. Different infectious agents (e.g. Chlamydia trachomat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/151 |
| _version_ | 1797198137935265792 |
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| author | A. A. Lukach O. A. Minyailo V. I. Konovalov A. I. Olkhovikov N. V. Kungurov N. M. Gerasimova N. P. Evstigneeva Ya. B. Beykin |
| author_facet | A. A. Lukach O. A. Minyailo V. I. Konovalov A. I. Olkhovikov N. V. Kungurov N. M. Gerasimova N. P. Evstigneeva Ya. B. Beykin |
| author_sort | A. A. Lukach |
| collection | DOAJ |
| description | Abstract. One hundred and ninety-nine patients with hyperplastic processes of reproductive system were examined, and 131 (66.16%) of them were found to be infected with Chlamydia or Ureaplasma. The mean age of female patients was 42,7±1,35 years. Different infectious agents (e.g. Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma hominis) were identified in cervical canal of uterine cervix and surgical specimens (biopsy samples of excised myoma, adenomyosis or endometrial hyperplasia). The infected patients were found to have decreased monocytes and neutrophils in blood counts, lower phagocytic activity of monocytes and neutrophils, and decreased bactericidal activity of leukocytes. Other findings included lower CD20+, CD8+ and rFAS CD 95 lymphocytes. Assessment of cytokine-synthesizing activity of CD3+ lymphocytes showed a decrease in both spontaneous and stimulated response (р < 0,001). A weakest spontaneous and stimulated response was found in CD3+/IL-4+ lymphocytes. Analysis of results obtained shows systemic immune disorders and impaired cytokine-synthesizing activity of CD3+ lymphocytes correlating with infection factors in the women with hyperplastic processes of reproductive system. (Med. Immunol., 2008, vol. 10, N 2-3, pp 223-228). |
| first_indexed | 2024-03-08T05:51:18Z |
| format | Article |
| id | doaj.art-0df5552db51c4f3faa12e176f98a45c7 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:55:05Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-0df5552db51c4f3faa12e176f98a45c72024-04-22T13:07:33ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01102-322322810.15789/1563-0625-2008-2-3-223-228148IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEMA. A. Lukach0O. A. Minyailo1V. I. Konovalov2A. I. Olkhovikov3N. V. Kungurov4N. M. Gerasimova5N. P. Evstigneeva6Ya. B. Beykin7ГОУ ВПО «Уральская государственная медицинская академия» РоссоцздраваГОУ ВПО «Уральская государственная медицинская академия» РоссоцздраваГОУ ВПО «Уральская государственная медицинская академия» РоссоцздраваГОУ ВПО «Уральская государственная медицинская академия» РоссоцздраваУральский научно-исследовательский институт дерматовенерологии и иммунопатологииУральский научно-исследовательский институт дерматовенерологии и иммунопатологииУральский научно-исследовательский институт дерматовенерологии и иммунопатологииМУ Клинико-диагностический Центр, г. ЕкатеринбургAbstract. One hundred and ninety-nine patients with hyperplastic processes of reproductive system were examined, and 131 (66.16%) of them were found to be infected with Chlamydia or Ureaplasma. The mean age of female patients was 42,7±1,35 years. Different infectious agents (e.g. Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma hominis) were identified in cervical canal of uterine cervix and surgical specimens (biopsy samples of excised myoma, adenomyosis or endometrial hyperplasia). The infected patients were found to have decreased monocytes and neutrophils in blood counts, lower phagocytic activity of monocytes and neutrophils, and decreased bactericidal activity of leukocytes. Other findings included lower CD20+, CD8+ and rFAS CD 95 lymphocytes. Assessment of cytokine-synthesizing activity of CD3+ lymphocytes showed a decrease in both spontaneous and stimulated response (р < 0,001). A weakest spontaneous and stimulated response was found in CD3+/IL-4+ lymphocytes. Analysis of results obtained shows systemic immune disorders and impaired cytokine-synthesizing activity of CD3+ lymphocytes correlating with infection factors in the women with hyperplastic processes of reproductive system. (Med. Immunol., 2008, vol. 10, N 2-3, pp 223-228).https://www.mimmun.ru/mimmun/article/view/151immunitycd3+ lymphocytescytokineshyperplastic processesinfection |
| spellingShingle | A. A. Lukach O. A. Minyailo V. I. Konovalov A. I. Olkhovikov N. V. Kungurov N. M. Gerasimova N. P. Evstigneeva Ya. B. Beykin IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM Медицинская иммунология immunity cd3+ lymphocytes cytokines hyperplastic processes infection |
| title | IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM |
| title_full | IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM |
| title_fullStr | IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM |
| title_full_unstemmed | IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM |
| title_short | IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM |
| title_sort | immunity and infection in women with hyperplastic states of immune system |
| topic | immunity cd3+ lymphocytes cytokines hyperplastic processes infection |
| url | https://www.mimmun.ru/mimmun/article/view/151 |
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