Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s disease

Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s disease

Exposure to pesticides in humans increases the risk of Parkinson’s disease (PD), but the mechanisms remain poorly understood. To elucidate these pathways, we dosed C57BL/6J mice with a combination of the pesticides maneb and paraquat. Behavioral analysis revealed motor deficits consistent with PD. S...

Full description

Bibliographic Details
Main Authors: Khan Arshad H., Lee Lydia K., Smith Desmond J.
Format: Article
Language:English
Published: De Gruyter 2022-09-01
Series:Translational Neuroscience
Subjects:
basal ganglia
maneb
paraquat
neurodegeneration
scrna-seq
Online Access:https://doi.org/10.1515/tnsci-2022-0237

Similar Items

Similar Items