Recent advances in ocular graft-versus-host disease
Ocular graft-versus-host-disease (GVHD) remains a significant clinical complication after allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other symptoms severely affect affected individuals’ quality of life. However, the diagnosis of and therapy for ocular GVH...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1092108/full |
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| author | Xianjing Cheng Xianjing Cheng Ruihao Huang Shiqin Huang Wei Fan Rongdi Yuan Xiaoqi Wang Xi Zhang Xi Zhang Xi Zhang |
| author_facet | Xianjing Cheng Xianjing Cheng Ruihao Huang Shiqin Huang Wei Fan Rongdi Yuan Xiaoqi Wang Xi Zhang Xi Zhang Xi Zhang |
| author_sort | Xianjing Cheng |
| collection | DOAJ |
| description | Ocular graft-versus-host-disease (GVHD) remains a significant clinical complication after allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other symptoms severely affect affected individuals’ quality of life. However, the diagnosis of and therapy for ocular GVHD involve a multidisciplinary approach and remain challenging for both hematologists and ophthalmologists, as there are no unified international criteria. Through an exploration of the complex pathogenesis of ocular GVHD, this review comprehensively summarizes the pathogenic mechanism, related tear biomarkers, and clinical characteristics of this disease. Novel therapies based on the mechanisms are also discussed to provide insights into the ocular GVHD treatment. |
| first_indexed | 2024-04-10T20:25:59Z |
| format | Article |
| id | doaj.art-0df6ffac001848b18bf1cb0e0b761fe1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T20:25:59Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0df6ffac001848b18bf1cb0e0b761fe12023-01-25T10:47:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011410.3389/fimmu.2023.10921081092108Recent advances in ocular graft-versus-host diseaseXianjing Cheng0Xianjing Cheng1Ruihao Huang2Shiqin Huang3Wei Fan4Rongdi Yuan5Xiaoqi Wang6Xi Zhang7Xi Zhang8Xi Zhang9Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, ChinaSchool of Medicine, Chongqing University, Chongqing, ChinaMedical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, ChinaMedical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, ChinaDepartment of Ophthalmology, Xinqiao Hospital, Army Medical University, Chongqing, ChinaDepartment of Ophthalmology, Xinqiao Hospital, Army Medical University, Chongqing, ChinaMedical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, ChinaMedical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, ChinaSchool of Medicine, Chongqing University, Chongqing, ChinaJinfeng Laboratory, Chongqing, ChinaOcular graft-versus-host-disease (GVHD) remains a significant clinical complication after allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other symptoms severely affect affected individuals’ quality of life. However, the diagnosis of and therapy for ocular GVHD involve a multidisciplinary approach and remain challenging for both hematologists and ophthalmologists, as there are no unified international criteria. Through an exploration of the complex pathogenesis of ocular GVHD, this review comprehensively summarizes the pathogenic mechanism, related tear biomarkers, and clinical characteristics of this disease. Novel therapies based on the mechanisms are also discussed to provide insights into the ocular GVHD treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1092108/fullocular graft-versus-host-diseaseclinical characteristicsthe pathogenic mechanismnovel therapeutic targetstear biomarkers |
| spellingShingle | Xianjing Cheng Xianjing Cheng Ruihao Huang Shiqin Huang Wei Fan Rongdi Yuan Xiaoqi Wang Xi Zhang Xi Zhang Xi Zhang Recent advances in ocular graft-versus-host disease Frontiers in Immunology ocular graft-versus-host-disease clinical characteristics the pathogenic mechanism novel therapeutic targets tear biomarkers |
| title | Recent advances in ocular graft-versus-host disease |
| title_full | Recent advances in ocular graft-versus-host disease |
| title_fullStr | Recent advances in ocular graft-versus-host disease |
| title_full_unstemmed | Recent advances in ocular graft-versus-host disease |
| title_short | Recent advances in ocular graft-versus-host disease |
| title_sort | recent advances in ocular graft versus host disease |
| topic | ocular graft-versus-host-disease clinical characteristics the pathogenic mechanism novel therapeutic targets tear biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1092108/full |
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