Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia
Diabetes mellitus during pregnancy, which can be classified into pregestational diabetes and gestational diabetes, has become much more prevalent worldwide. Maternal diabetes fosters an intrauterine abnormal environment for fetus, which not only influences pregnancy outcomes, but also leads to fetal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1067282/full |
| _version_ | 1797826600069234688 |
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| author | Yi-Shang Yan Yi-Shang Yan Chun Feng Chun Feng Dan-Qing Yu Dan-Qing Yu Shen Tian Shen Tian Yin Zhou Yin Zhou Yi-Ting Huang Yi-Ting Huang Yi-Ting Cai Jian Chen Miao-Miao Zhu Min Jin Min Jin |
| author_facet | Yi-Shang Yan Yi-Shang Yan Chun Feng Chun Feng Dan-Qing Yu Dan-Qing Yu Shen Tian Shen Tian Yin Zhou Yin Zhou Yi-Ting Huang Yi-Ting Huang Yi-Ting Cai Jian Chen Miao-Miao Zhu Min Jin Min Jin |
| author_sort | Yi-Shang Yan |
| collection | DOAJ |
| description | Diabetes mellitus during pregnancy, which can be classified into pregestational diabetes and gestational diabetes, has become much more prevalent worldwide. Maternal diabetes fosters an intrauterine abnormal environment for fetus, which not only influences pregnancy outcomes, but also leads to fetal anomaly and development of diseases in later life, such as metabolic and cardiovascular diseases, neuropsychiatric outcomes, reproduction malformation, and immune dysfunction. The underlying mechanisms are comprehensive and ambiguous, which mainly focus on microbiota, inflammation, reactive oxygen species, cell viability, and epigenetics. This review concluded with the influence of intrauterine hyperglycemia on fetal structure development and organ function on later life and outlined potential mechanisms that underpin the development of diseases in adulthood. Maternal diabetes leaves an effect that continues generations after generations through gametes, thus more attention should be paid to the prevention and treatment of diabetes to rescue the pathological attacks of maternal diabetes from the offspring. |
| first_indexed | 2024-04-09T12:34:59Z |
| format | Article |
| id | doaj.art-0df7d9167118401ba53da8d5be6c3cbe |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-09T12:34:59Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-0df7d9167118401ba53da8d5be6c3cbe2023-05-15T13:22:17ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-05-011010.3389/fnut.2023.10672821067282Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemiaYi-Shang Yan0Yi-Shang Yan1Chun Feng2Chun Feng3Dan-Qing Yu4Dan-Qing Yu5Shen Tian6Shen Tian7Yin Zhou8Yin Zhou9Yi-Ting Huang10Yi-Ting Huang11Yi-Ting Cai12Jian Chen13Miao-Miao Zhu14Min Jin15Min Jin16Department of Reproductive Medicine, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics, Ministry of Education, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Reproductive Medicine, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics, Ministry of Education, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Reproductive Medicine, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics, Ministry of Education, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Reproductive Medicine, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics, Ministry of Education, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Reproductive Medicine, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics, Ministry of Education, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Reproductive Medicine, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics, Ministry of Education, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics, Ministry of Education, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics, Ministry of Education, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Operating Theatre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Reproductive Medicine, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics, Ministry of Education, School of Medicine, Zhejiang University, Hangzhou, ChinaDiabetes mellitus during pregnancy, which can be classified into pregestational diabetes and gestational diabetes, has become much more prevalent worldwide. Maternal diabetes fosters an intrauterine abnormal environment for fetus, which not only influences pregnancy outcomes, but also leads to fetal anomaly and development of diseases in later life, such as metabolic and cardiovascular diseases, neuropsychiatric outcomes, reproduction malformation, and immune dysfunction. The underlying mechanisms are comprehensive and ambiguous, which mainly focus on microbiota, inflammation, reactive oxygen species, cell viability, and epigenetics. This review concluded with the influence of intrauterine hyperglycemia on fetal structure development and organ function on later life and outlined potential mechanisms that underpin the development of diseases in adulthood. Maternal diabetes leaves an effect that continues generations after generations through gametes, thus more attention should be paid to the prevention and treatment of diabetes to rescue the pathological attacks of maternal diabetes from the offspring.https://www.frontiersin.org/articles/10.3389/fnut.2023.1067282/fullmaternal diabetesoffspringfetal developmentlong-term outcomespotential mechanisms |
| spellingShingle | Yi-Shang Yan Yi-Shang Yan Chun Feng Chun Feng Dan-Qing Yu Dan-Qing Yu Shen Tian Shen Tian Yin Zhou Yin Zhou Yi-Ting Huang Yi-Ting Huang Yi-Ting Cai Jian Chen Miao-Miao Zhu Min Jin Min Jin Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia Frontiers in Nutrition maternal diabetes offspring fetal development long-term outcomes potential mechanisms |
| title | Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia |
| title_full | Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia |
| title_fullStr | Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia |
| title_full_unstemmed | Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia |
| title_short | Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia |
| title_sort | long term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia |
| topic | maternal diabetes offspring fetal development long-term outcomes potential mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1067282/full |
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