Rational Design and In Vivo Characterization of mRNA-Encoded Broadly Neutralizing Antibody Combinations against HIV-1

Rational Design and In Vivo Characterization of mRNA-Encoded Broadly Neutralizing Antibody Combinations against HIV-1

Monoclonal antibodies have been used successfully as recombinant protein therapy; however, for HIV, multiple broadly neutralizing antibodies may be necessary. We used the mRNA-LNP platform for in vivo co-expression of 3 broadly neutralizing antibodies, PGDM1400, PGT121, and N6, directed against the...

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Bibliographic Details
Main Authors: Elisabeth Narayanan, Samantha Falcone, Sayda M. Elbashir, Husain Attarwala, Kimberly Hassett, Michael S. Seaman, Andrea Carfi, Sunny Himansu
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antibodies
Subjects:
HIV
mRNA
antibodies
broadly neutralizing antibodies
Online Access:https://www.mdpi.com/2073-4468/11/4/67

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