Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys
Metastable Ti–Nb alloys are promising bone-implant materials due to improved mechanical biofunctionality and biocompatibility. To overcome increasing bacterial infection risk, alloying with antibacterial elements is a promising strategy. This study investigates the effect of minor gallium (Ga) addit...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Journal of Materials Research and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785423014679 |
| _version_ | 1797745166709161984 |
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| author | Adnan Akman Ludovico Andrea Alberta Paula Milena Giraldo-Osorno Adam Benedict Turner Martin Hantusch Anders Palmquist Margarita Trobos Mariana Calin Annett Gebert |
| author_facet | Adnan Akman Ludovico Andrea Alberta Paula Milena Giraldo-Osorno Adam Benedict Turner Martin Hantusch Anders Palmquist Margarita Trobos Mariana Calin Annett Gebert |
| author_sort | Adnan Akman |
| collection | DOAJ |
| description | Metastable Ti–Nb alloys are promising bone-implant materials due to improved mechanical biofunctionality and biocompatibility. To overcome increasing bacterial infection risk, alloying with antibacterial elements is a promising strategy. This study investigates the effect of minor gallium (Ga) additions (4, 8 wt% Ga) to as-cast and solution-treated β-type Ti–45Nb-based alloy (96(Ti–45Nb)-4Ga, 92(Ti–45Nb)-8Ga (wt.%)) on corrosion and passive film properties, as well as cytocompatibility and antibacterial activity. The electrochemical properties were evaluated by potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), and Mott-Schottky analyses in phosphate-buffered saline (PBS). X-ray photoelectron spectroscopy (XPS) was performed to analyze the chemical composition of passive films. Early adhesion and viability of macrophages and Staphylococcus aureus were assessed by nucleocounting and colony-forming unit counting, respectively. The results showed that high corrosion resistance and passive film properties of Ti–45Nb are retained and even slightly improved with Ga. EIS results revealed that Ga addition improves the passive film resistance. XPS measurements of 92(Ti–45Nb)-8Ga show that the passive film contains Ti-, Nb- and Ga-based oxides, implying the formation of mixed (Ti–Nb-Ga) oxides. In addition, marginal Ga ion release rate was detected under free corrosion conditions. Therefore, it can be assumed that Ga species may contribute to passive film formation on Ga-containing alloys. The 92(Ti–45Nb)-8Ga elicited an antibacterial effect against S. aureus compared to cp-Ti at 4 h. Moreover, Ga-containing alloys showed good cytocompatibility with THP-1 macrophages at 24 h. In conclusion, it was demonstrated that Ga additions to Ti–45Nb are beneficial to corrosion resistance and showed promising initial host and bacterial interactions. |
| first_indexed | 2024-03-12T15:19:31Z |
| format | Article |
| id | doaj.art-0dfa0d8df2c94f46bde50c1e1b89d836 |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-03-12T15:19:31Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-0dfa0d8df2c94f46bde50c1e1b89d8362023-08-11T05:33:58ZengElsevierJournal of Materials Research and Technology2238-78542023-07-012541104124Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloysAdnan Akman0Ludovico Andrea Alberta1Paula Milena Giraldo-Osorno2Adam Benedict Turner3Martin Hantusch4Anders Palmquist5Margarita Trobos6Mariana Calin7Annett Gebert8Leibniz Institute for Solid State and Materials Research, Helmholtzstr. 20, D-01069 Dresden, Germany; Corresponding author.Leibniz Institute for Solid State and Materials Research, Helmholtzstr. 20, D-01069 Dresden, GermanyDepartment of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg, Gothenburg, Sweden; Centre for Antibiotic Resistance Research in Gothenburg (CARe), University of Gothenburg, Gothenburg, SwedenDepartment of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg, Gothenburg, Sweden; Centre for Antibiotic Resistance Research in Gothenburg (CARe), University of Gothenburg, Gothenburg, SwedenLeibniz Institute for Solid State and Materials Research, Helmholtzstr. 20, D-01069 Dresden, GermanyDepartment of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg, Gothenburg, SwedenDepartment of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg, Gothenburg, Sweden; Centre for Antibiotic Resistance Research in Gothenburg (CARe), University of Gothenburg, Gothenburg, SwedenLeibniz Institute for Solid State and Materials Research, Helmholtzstr. 20, D-01069 Dresden, GermanyLeibniz Institute for Solid State and Materials Research, Helmholtzstr. 20, D-01069 Dresden, GermanyMetastable Ti–Nb alloys are promising bone-implant materials due to improved mechanical biofunctionality and biocompatibility. To overcome increasing bacterial infection risk, alloying with antibacterial elements is a promising strategy. This study investigates the effect of minor gallium (Ga) additions (4, 8 wt% Ga) to as-cast and solution-treated β-type Ti–45Nb-based alloy (96(Ti–45Nb)-4Ga, 92(Ti–45Nb)-8Ga (wt.%)) on corrosion and passive film properties, as well as cytocompatibility and antibacterial activity. The electrochemical properties were evaluated by potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), and Mott-Schottky analyses in phosphate-buffered saline (PBS). X-ray photoelectron spectroscopy (XPS) was performed to analyze the chemical composition of passive films. Early adhesion and viability of macrophages and Staphylococcus aureus were assessed by nucleocounting and colony-forming unit counting, respectively. The results showed that high corrosion resistance and passive film properties of Ti–45Nb are retained and even slightly improved with Ga. EIS results revealed that Ga addition improves the passive film resistance. XPS measurements of 92(Ti–45Nb)-8Ga show that the passive film contains Ti-, Nb- and Ga-based oxides, implying the formation of mixed (Ti–Nb-Ga) oxides. In addition, marginal Ga ion release rate was detected under free corrosion conditions. Therefore, it can be assumed that Ga species may contribute to passive film formation on Ga-containing alloys. The 92(Ti–45Nb)-8Ga elicited an antibacterial effect against S. aureus compared to cp-Ti at 4 h. Moreover, Ga-containing alloys showed good cytocompatibility with THP-1 macrophages at 24 h. In conclusion, it was demonstrated that Ga additions to Ti–45Nb are beneficial to corrosion resistance and showed promising initial host and bacterial interactions.http://www.sciencedirect.com/science/article/pii/S2238785423014679β titanium alloyGalliumCorrosionPassive filmAntibacterialCytocompatibility |
| spellingShingle | Adnan Akman Ludovico Andrea Alberta Paula Milena Giraldo-Osorno Adam Benedict Turner Martin Hantusch Anders Palmquist Margarita Trobos Mariana Calin Annett Gebert Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys Journal of Materials Research and Technology β titanium alloy Gallium Corrosion Passive film Antibacterial Cytocompatibility |
| title | Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys |
| title_full | Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys |
| title_fullStr | Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys |
| title_full_unstemmed | Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys |
| title_short | Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys |
| title_sort | effect of minor gallium addition on corrosion passivity and antibacterial behaviour of novel β type ti nb alloys |
| topic | β titanium alloy Gallium Corrosion Passive film Antibacterial Cytocompatibility |
| url | http://www.sciencedirect.com/science/article/pii/S2238785423014679 |
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