Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative review
Chronic low-grade inflammation plays a role in the pathophysiology of bipolar disorder. Recent studies have shown that periodontitis can affect the central nervous system by activating inflammatory mediators in the brain. However, only a few studies have examined the association between periodontiti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sungkyunkwan University School of Medi
2023-09-01
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| Series: | Precision and Future Medicine |
| Subjects: | |
| Online Access: | http://www.pfmjournal.org/upload/pdf/pfm-2023-00086.pdf |
| _version_ | 1827787111744405504 |
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| author | Ji Hyun Baek Sun Jae Jung Amy Peters Alpdogan Kantarci Andrew A. Nierenberg |
| author_facet | Ji Hyun Baek Sun Jae Jung Amy Peters Alpdogan Kantarci Andrew A. Nierenberg |
| author_sort | Ji Hyun Baek |
| collection | DOAJ |
| description | Chronic low-grade inflammation plays a role in the pathophysiology of bipolar disorder. Recent studies have shown that periodontitis can affect the central nervous system by activating inflammatory mediators in the brain. However, only a few studies have examined the association between periodontitis and bipolar disorder. Here, we aimed to review the current evidence on the association between periodontal diseases and bipolar disorder, its potential mechanisms, and future research directions. Studies so far suggested that periodontal diseases were more common in patients with bipolar disorder than in the general population. Patients with bipolar disorder generally have poor oral hygiene owing to poor self-care, smoking, alcohol abuse, and the effects of psychotropic medications. Proposed mechanisms underlying this association include the effects of inflammatory mediators, direct invasion of oral microbiota, modulation of the neurotransmitter system, and impact on the vagus nerve and hypothalamus-pituitary- adrenal axis. Additional clinical studies examining the prevalence of periodontal diseases and their association with the clinical features of bipolar disorder are necessary. Clinical studies targeting the treatment of periodontal diseases for primary or secondary prevention of bipolar disorder are warranted. |
| first_indexed | 2024-03-11T16:44:54Z |
| format | Article |
| id | doaj.art-0dfb08e24ee44a22b1e286deac2bdff0 |
| institution | Directory Open Access Journal |
| issn | 2508-7940 2508-7959 |
| language | English |
| last_indexed | 2024-03-11T16:44:54Z |
| publishDate | 2023-09-01 |
| publisher | Sungkyunkwan University School of Medi |
| record_format | Article |
| series | Precision and Future Medicine |
| spelling | doaj.art-0dfb08e24ee44a22b1e286deac2bdff02023-10-23T01:13:53ZengSungkyunkwan University School of MediPrecision and Future Medicine2508-79402508-79592023-09-017311712210.23838/pfm.2023.00086150Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative reviewJi Hyun Baek0Sun Jae Jung1Amy Peters2Alpdogan Kantarci3Andrew A. Nierenberg4 Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea Dauten Family Center for Bipolar Treatment Innovation, Massachusetts General Hospital, Boston, MA, USA Forsyth Institute, Cambridge, MA, USA Dauten Family Center for Bipolar Treatment Innovation, Massachusetts General Hospital, Boston, MA, USAChronic low-grade inflammation plays a role in the pathophysiology of bipolar disorder. Recent studies have shown that periodontitis can affect the central nervous system by activating inflammatory mediators in the brain. However, only a few studies have examined the association between periodontitis and bipolar disorder. Here, we aimed to review the current evidence on the association between periodontal diseases and bipolar disorder, its potential mechanisms, and future research directions. Studies so far suggested that periodontal diseases were more common in patients with bipolar disorder than in the general population. Patients with bipolar disorder generally have poor oral hygiene owing to poor self-care, smoking, alcohol abuse, and the effects of psychotropic medications. Proposed mechanisms underlying this association include the effects of inflammatory mediators, direct invasion of oral microbiota, modulation of the neurotransmitter system, and impact on the vagus nerve and hypothalamus-pituitary- adrenal axis. Additional clinical studies examining the prevalence of periodontal diseases and their association with the clinical features of bipolar disorder are necessary. Clinical studies targeting the treatment of periodontal diseases for primary or secondary prevention of bipolar disorder are warranted.http://www.pfmjournal.org/upload/pdf/pfm-2023-00086.pdfbipolar disorderneuroinflammationperiodontitisprimary prevention |
| spellingShingle | Ji Hyun Baek Sun Jae Jung Amy Peters Alpdogan Kantarci Andrew A. Nierenberg Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative review Precision and Future Medicine bipolar disorder neuroinflammation periodontitis primary prevention |
| title | Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative review |
| title_full | Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative review |
| title_fullStr | Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative review |
| title_full_unstemmed | Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative review |
| title_short | Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative review |
| title_sort | association between periodontal diseases and bipolar disorder implications for therapeutic interventions a narrative review |
| topic | bipolar disorder neuroinflammation periodontitis primary prevention |
| url | http://www.pfmjournal.org/upload/pdf/pfm-2023-00086.pdf |
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