miRNAs as Therapeutic Tools in Alzheimer’s Disease
Alzheimer’s disease (AD), an age-dependent, progressive neurodegenerative disorder, is the most common type of dementia, accounting for 50–70% of all dementia cases. Due to the increasing incidence and corresponding socioeconomic burden of dementia, it has rapidly emerged as a challenge to public he...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/13012 |
| _version_ | 1797507684155523072 |
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| author | Chang Youn Lee In Soo Ryu Jin-Hyeob Ryu Hyun-Jeong Cho |
| author_facet | Chang Youn Lee In Soo Ryu Jin-Hyeob Ryu Hyun-Jeong Cho |
| author_sort | Chang Youn Lee |
| collection | DOAJ |
| description | Alzheimer’s disease (AD), an age-dependent, progressive neurodegenerative disorder, is the most common type of dementia, accounting for 50–70% of all dementia cases. Due to the increasing incidence and corresponding socioeconomic burden of dementia, it has rapidly emerged as a challenge to public health worldwide. The characteristics of AD include the development of extracellular amyloid-beta plaques and intracellular neurofibrillary tangles, vascular changes, neuronal inflammation, and progressive brain atrophy. However, the complexity of the biology of AD has hindered progress in elucidating the underlying pathophysiological mechanisms of AD, and the development of effective treatments. MicroRNAs (miRNAs, which are endogenous, noncoding RNAs of approximately 22 nucleotides that function as posttranscriptional regulators of various genes) are attracting attention as powerful tools for studying the mechanisms of diseases, as they are involved in several biological processes and diseases, including AD. AD is a multifactorial disease, and several reports have suggested that miRNAs play an important role in the pathological processes of AD. In this review, the basic biology of miRNAs is described, and the function and physiology of miRNAs in the pathological processes of AD are highlighted. In addition, the limitations of current pharmaceutical therapies for the treatment of AD and the development of miRNA-based next-generation therapies are discussed. |
| first_indexed | 2024-03-10T04:51:56Z |
| format | Article |
| id | doaj.art-0dfb0a7d31d64122ac9a018db566abb1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:51:56Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0dfb0a7d31d64122ac9a018db566abb12023-11-23T02:31:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122231301210.3390/ijms222313012miRNAs as Therapeutic Tools in Alzheimer’s DiseaseChang Youn Lee0In Soo Ryu1Jin-Hyeob Ryu2Hyun-Jeong Cho3BIORCHESTRA Co., Ltd., Techno4-ro 17, Daejeon 34013, KoreaBIORCHESTRA Co., Ltd., Techno4-ro 17, Daejeon 34013, KoreaBIORCHESTRA Co., Ltd., Techno4-ro 17, Daejeon 34013, KoreaDepartment of Biomedical Laboratory Science, College of Medical Science, Konyang University, 158, Gwanjeodong-ro, Daejeon 35365, KoreaAlzheimer’s disease (AD), an age-dependent, progressive neurodegenerative disorder, is the most common type of dementia, accounting for 50–70% of all dementia cases. Due to the increasing incidence and corresponding socioeconomic burden of dementia, it has rapidly emerged as a challenge to public health worldwide. The characteristics of AD include the development of extracellular amyloid-beta plaques and intracellular neurofibrillary tangles, vascular changes, neuronal inflammation, and progressive brain atrophy. However, the complexity of the biology of AD has hindered progress in elucidating the underlying pathophysiological mechanisms of AD, and the development of effective treatments. MicroRNAs (miRNAs, which are endogenous, noncoding RNAs of approximately 22 nucleotides that function as posttranscriptional regulators of various genes) are attracting attention as powerful tools for studying the mechanisms of diseases, as they are involved in several biological processes and diseases, including AD. AD is a multifactorial disease, and several reports have suggested that miRNAs play an important role in the pathological processes of AD. In this review, the basic biology of miRNAs is described, and the function and physiology of miRNAs in the pathological processes of AD are highlighted. In addition, the limitations of current pharmaceutical therapies for the treatment of AD and the development of miRNA-based next-generation therapies are discussed.https://www.mdpi.com/1422-0067/22/23/13012Alzheimer’s diseasepharmacotherapymicroRNAamyloid-betatauneuroinflammation |
| spellingShingle | Chang Youn Lee In Soo Ryu Jin-Hyeob Ryu Hyun-Jeong Cho miRNAs as Therapeutic Tools in Alzheimer’s Disease International Journal of Molecular Sciences Alzheimer’s disease pharmacotherapy microRNA amyloid-beta tau neuroinflammation |
| title | miRNAs as Therapeutic Tools in Alzheimer’s Disease |
| title_full | miRNAs as Therapeutic Tools in Alzheimer’s Disease |
| title_fullStr | miRNAs as Therapeutic Tools in Alzheimer’s Disease |
| title_full_unstemmed | miRNAs as Therapeutic Tools in Alzheimer’s Disease |
| title_short | miRNAs as Therapeutic Tools in Alzheimer’s Disease |
| title_sort | mirnas as therapeutic tools in alzheimer s disease |
| topic | Alzheimer’s disease pharmacotherapy microRNA amyloid-beta tau neuroinflammation |
| url | https://www.mdpi.com/1422-0067/22/23/13012 |
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