Detection of EGFR Mutations in Plasma cfDNA and Paired CTCs of NSCLC Patients before and after Osimertinib Therapy Using Crystal Digital PCR

Detection of EGFR Mutations in Plasma cfDNA and Paired CTCs of NSCLC Patients before and after Osimertinib Therapy Using Crystal Digital PCR

Circulating tumor DNA (ctDNA) analysis has clinical utility in EGFR mutant NSCLC. Circulating tumor cells (CTCs) consist a unique source of information at the cellular level. Digital PCR (dPCR) is a valuable tool for accurate and valid analysis of gene mutations in liquid biopsy analysis. In the pre...

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Bibliographic Details
Main Authors: Aliki Ntzifa, Athanasios Kotsakis, Vassilis Georgoulias, Evi Lianidou
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
liquid biopsy
circulating tumor DNA (ctDNA)
circulating tumor cells (CTC)
crystal digital PCR
EGFR mutations
osimertinib
Online Access:https://www.mdpi.com/2072-6694/13/11/2736

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