Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis
Vasospastic angina (VA) is a functional disease of the coronary artery and occurs in an angiographically normal coronary artery. However, it may also occur with coronary artery stenosis. We investigated the effect of coronary artery stenosis on clinical outcomes in VA patients. Study data were obtai...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/15/3341 |
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| author | Hyun-Jin Kim Min-Ho Lee Sang-Ho Jo Won-Woo Seo Hack-Lyoung Kim Kwan-Yong Lee Tae-Hyun Yang Sung-Ho Her Seung-Hwan Han Byoung-Kwon Lee Keun-Ho Park Seung-Woon Rha Hyeon-Cheol Gwon Dong-Ju Choi Sang-Hong Baek |
| author_facet | Hyun-Jin Kim Min-Ho Lee Sang-Ho Jo Won-Woo Seo Hack-Lyoung Kim Kwan-Yong Lee Tae-Hyun Yang Sung-Ho Her Seung-Hwan Han Byoung-Kwon Lee Keun-Ho Park Seung-Woon Rha Hyeon-Cheol Gwon Dong-Ju Choi Sang-Hong Baek |
| author_sort | Hyun-Jin Kim |
| collection | DOAJ |
| description | Vasospastic angina (VA) is a functional disease of the coronary artery and occurs in an angiographically normal coronary artery. However, it may also occur with coronary artery stenosis. We investigated the effect of coronary artery stenosis on clinical outcomes in VA patients. Study data were obtained from a prospective multicenter registry that included patients who had symptoms of VA. Patients were classified into two groups according to presence of significant coronary artery stenosis. Among 1920 patients with VA, 189 patients were classified in the “significant stenosis” group. The one-year composite clinical events rate was significantly higher in the significant stenosis group than in the “no significant stenosis” group (5.8% vs. 1.4%, respectively; <i>p</i> < 0.001). Additionally, the prevalence of ACS was significantly greater in the “significant stenosis” group (4.8% vs. 0.9%, respectively; <i>p</i> < 0.001). After propensity score matching, the adverse effects of significant stenosis remained. In addition, significant stenosis was independently associated with a 6.67-fold increased risk of ACS in VA patients. In conclusion, significant coronary artery stenosis can increase the adverse clinical outcomes in VA patients at long-term follow-up. Clinicians should manage traditional risk factors associated with atherosclerosis and control vasospasm as well as reduce the burden of atherosclerosis. |
| first_indexed | 2024-03-10T09:12:41Z |
| format | Article |
| id | doaj.art-0dfe06676ddf4817a6d1aa6c76b53ea9 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:12:41Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0dfe06676ddf4817a6d1aa6c76b53ea92023-11-22T05:49:21ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011015334110.3390/jcm10153341Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched AnalysisHyun-Jin Kim0Min-Ho Lee1Sang-Ho Jo2Won-Woo Seo3Hack-Lyoung Kim4Kwan-Yong Lee5Tae-Hyun Yang6Sung-Ho Her7Seung-Hwan Han8Byoung-Kwon Lee9Keun-Ho Park10Seung-Woon Rha11Hyeon-Cheol Gwon12Dong-Ju Choi13Sang-Hong Baek14Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul 04763, KoreaDivision of Cardiology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, KoreaCardiovascular Center, Hallym University Sacred Heart Hospital, Anyang-si 14068, KoreaDivision of Cardiology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 05355, KoreaCardiovascular Center, Seoul National University Boramae Medical Center, Seoul 07061, KoreaDepartment of Cardiovascular Medicine, Incheon St. Mary’s Hospital, The Catholic University of Korea, Incheon 21431, KoreaDepartment of Cardiovascular Medicine, Busan Paik Hospital, Inje University, Busan 47392, KoreaDepartment of Cardiovascular Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Suwon 16247, KoreaDepartment of Cardiovascular Medicine, Gil Medical Center, Gachon University, Incheon 21565, KoreaDepartment of Cardiovascular Medicine, Gangnam Severance Hospital, Yonsei University, Seoul 06273, KoreaThe Heart Center, Chosun Medical Center, Gwangju 61453, KoreaDepartment of Cardiovascular Medicine, Guro Hospital, Korea University, Seoul 08308, KoreaDepartment of Cardiovascular Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul 06351, KoreaDivision of Cardiology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDivision of Cardiology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul 06649, KoreaVasospastic angina (VA) is a functional disease of the coronary artery and occurs in an angiographically normal coronary artery. However, it may also occur with coronary artery stenosis. We investigated the effect of coronary artery stenosis on clinical outcomes in VA patients. Study data were obtained from a prospective multicenter registry that included patients who had symptoms of VA. Patients were classified into two groups according to presence of significant coronary artery stenosis. Among 1920 patients with VA, 189 patients were classified in the “significant stenosis” group. The one-year composite clinical events rate was significantly higher in the significant stenosis group than in the “no significant stenosis” group (5.8% vs. 1.4%, respectively; <i>p</i> < 0.001). Additionally, the prevalence of ACS was significantly greater in the “significant stenosis” group (4.8% vs. 0.9%, respectively; <i>p</i> < 0.001). After propensity score matching, the adverse effects of significant stenosis remained. In addition, significant stenosis was independently associated with a 6.67-fold increased risk of ACS in VA patients. In conclusion, significant coronary artery stenosis can increase the adverse clinical outcomes in VA patients at long-term follow-up. Clinicians should manage traditional risk factors associated with atherosclerosis and control vasospasm as well as reduce the burden of atherosclerosis.https://www.mdpi.com/2077-0383/10/15/3341vasospastic anginacoronary artery stenosisacute coronary syndrome |
| spellingShingle | Hyun-Jin Kim Min-Ho Lee Sang-Ho Jo Won-Woo Seo Hack-Lyoung Kim Kwan-Yong Lee Tae-Hyun Yang Sung-Ho Her Seung-Hwan Han Byoung-Kwon Lee Keun-Ho Park Seung-Woon Rha Hyeon-Cheol Gwon Dong-Ju Choi Sang-Hong Baek Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis Journal of Clinical Medicine vasospastic angina coronary artery stenosis acute coronary syndrome |
| title | Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis |
| title_full | Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis |
| title_fullStr | Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis |
| title_full_unstemmed | Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis |
| title_short | Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis |
| title_sort | effect of significant coronary artery stenosis on prognosis in patients with vasospastic angina a propensity score matched analysis |
| topic | vasospastic angina coronary artery stenosis acute coronary syndrome |
| url | https://www.mdpi.com/2077-0383/10/15/3341 |
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