OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block

The maintenance of genome stability requires the coordinated actions of multiple proteins and protein complexes, that are collectively known as genome guardians. Within this broadly defined family is a subset of proteins that contain oligonucleotide/oligosaccharide-binding folds (OB-fold). While OB-...

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Main Author: Piero R. Bianco
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.784451/full
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author Piero R. Bianco
author_facet Piero R. Bianco
author_sort Piero R. Bianco
collection DOAJ
description The maintenance of genome stability requires the coordinated actions of multiple proteins and protein complexes, that are collectively known as genome guardians. Within this broadly defined family is a subset of proteins that contain oligonucleotide/oligosaccharide-binding folds (OB-fold). While OB-folds are widely associated with binding to single-stranded DNA this view is no longer an accurate depiction of how these domains are utilized. Instead, the core of the OB-fold is modified and adapted to facilitate binding to a variety of DNA substrates (both single- and double-stranded), phospholipids, and proteins, as well as enabling catalytic function to a multi-subunit complex. The flexibility accompanied by distinctive oligomerization states and quaternary structures enables OB-fold genome guardians to maintain the integrity of the genome via a myriad of complex and dynamic, protein-protein; protein-DNA, and protein-lipid interactions in both prokaryotes and eukaryotes.
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spelling doaj.art-0dfe4eab99564aa4a25f9e5dc9aff8da2022-12-21T23:44:25ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-02-01910.3389/fmolb.2022.784451784451OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building BlockPiero R. BiancoThe maintenance of genome stability requires the coordinated actions of multiple proteins and protein complexes, that are collectively known as genome guardians. Within this broadly defined family is a subset of proteins that contain oligonucleotide/oligosaccharide-binding folds (OB-fold). While OB-folds are widely associated with binding to single-stranded DNA this view is no longer an accurate depiction of how these domains are utilized. Instead, the core of the OB-fold is modified and adapted to facilitate binding to a variety of DNA substrates (both single- and double-stranded), phospholipids, and proteins, as well as enabling catalytic function to a multi-subunit complex. The flexibility accompanied by distinctive oligomerization states and quaternary structures enables OB-fold genome guardians to maintain the integrity of the genome via a myriad of complex and dynamic, protein-protein; protein-DNA, and protein-lipid interactions in both prokaryotes and eukaryotes.https://www.frontiersin.org/articles/10.3389/fmolb.2022.784451/fullOB-foldSH3 domainPXXPgenome guardianSBB familyMCM
spellingShingle Piero R. Bianco
OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block
Frontiers in Molecular Biosciences
OB-fold
SH3 domain
PXXP
genome guardian
SBB family
MCM
title OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block
title_full OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block
title_fullStr OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block
title_full_unstemmed OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block
title_short OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block
title_sort ob fold families of genome guardians a universal theme constructed from the small β barrel building block
topic OB-fold
SH3 domain
PXXP
genome guardian
SBB family
MCM
url https://www.frontiersin.org/articles/10.3389/fmolb.2022.784451/full
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