OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block
The maintenance of genome stability requires the coordinated actions of multiple proteins and protein complexes, that are collectively known as genome guardians. Within this broadly defined family is a subset of proteins that contain oligonucleotide/oligosaccharide-binding folds (OB-fold). While OB-...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2022-02-01
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Series: | Frontiers in Molecular Biosciences |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.784451/full |
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author | Piero R. Bianco |
author_facet | Piero R. Bianco |
author_sort | Piero R. Bianco |
collection | DOAJ |
description | The maintenance of genome stability requires the coordinated actions of multiple proteins and protein complexes, that are collectively known as genome guardians. Within this broadly defined family is a subset of proteins that contain oligonucleotide/oligosaccharide-binding folds (OB-fold). While OB-folds are widely associated with binding to single-stranded DNA this view is no longer an accurate depiction of how these domains are utilized. Instead, the core of the OB-fold is modified and adapted to facilitate binding to a variety of DNA substrates (both single- and double-stranded), phospholipids, and proteins, as well as enabling catalytic function to a multi-subunit complex. The flexibility accompanied by distinctive oligomerization states and quaternary structures enables OB-fold genome guardians to maintain the integrity of the genome via a myriad of complex and dynamic, protein-protein; protein-DNA, and protein-lipid interactions in both prokaryotes and eukaryotes. |
first_indexed | 2024-12-13T13:20:07Z |
format | Article |
id | doaj.art-0dfe4eab99564aa4a25f9e5dc9aff8da |
institution | Directory Open Access Journal |
issn | 2296-889X |
language | English |
last_indexed | 2024-12-13T13:20:07Z |
publishDate | 2022-02-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Molecular Biosciences |
spelling | doaj.art-0dfe4eab99564aa4a25f9e5dc9aff8da2022-12-21T23:44:25ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-02-01910.3389/fmolb.2022.784451784451OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building BlockPiero R. BiancoThe maintenance of genome stability requires the coordinated actions of multiple proteins and protein complexes, that are collectively known as genome guardians. Within this broadly defined family is a subset of proteins that contain oligonucleotide/oligosaccharide-binding folds (OB-fold). While OB-folds are widely associated with binding to single-stranded DNA this view is no longer an accurate depiction of how these domains are utilized. Instead, the core of the OB-fold is modified and adapted to facilitate binding to a variety of DNA substrates (both single- and double-stranded), phospholipids, and proteins, as well as enabling catalytic function to a multi-subunit complex. The flexibility accompanied by distinctive oligomerization states and quaternary structures enables OB-fold genome guardians to maintain the integrity of the genome via a myriad of complex and dynamic, protein-protein; protein-DNA, and protein-lipid interactions in both prokaryotes and eukaryotes.https://www.frontiersin.org/articles/10.3389/fmolb.2022.784451/fullOB-foldSH3 domainPXXPgenome guardianSBB familyMCM |
spellingShingle | Piero R. Bianco OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block Frontiers in Molecular Biosciences OB-fold SH3 domain PXXP genome guardian SBB family MCM |
title | OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block |
title_full | OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block |
title_fullStr | OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block |
title_full_unstemmed | OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block |
title_short | OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block |
title_sort | ob fold families of genome guardians a universal theme constructed from the small β barrel building block |
topic | OB-fold SH3 domain PXXP genome guardian SBB family MCM |
url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.784451/full |
work_keys_str_mv | AT pierorbianco obfoldfamiliesofgenomeguardiansauniversalthemeconstructedfromthesmallbbarrelbuildingblock |