Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein
Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen. Antibodies to FHbp can neutralize its function by inhibiting binding o...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-03-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2019.1664241 |
| _version_ | 1827809645094240256 |
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| author | Peter T. Beernink |
| author_facet | Peter T. Beernink |
| author_sort | Peter T. Beernink |
| collection | DOAJ |
| description | Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen. Antibodies to FHbp can neutralize its function by inhibiting binding of FH to the bacteria and confer robust complement-mediated protection. However, in the presence of human or primate FH, antibodies to FHbp do not inhibit FH binding and the protective antibody responses are decreased. This immune suppression can be overcome by modification of the FHbp antigen to decrease FH binding, which modulates the antibody repertoire to inhibit FH binding and increase protection. When FHbp is present at sufficient density on the bacterial surface, two or more antibodies can synergize to activate the complement system. Thus, modification of FHbp antigens to decrease FH binding expands the anti-FHbp antibody repertoire and increases the potential for synergistic activity. |
| first_indexed | 2024-03-11T22:43:24Z |
| format | Article |
| id | doaj.art-0e0025571cb847cc9579b2c6b6a34d4f |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:43:24Z |
| publishDate | 2020-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-0e0025571cb847cc9579b2c6b6a34d4f2023-09-22T08:45:33ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2020-03-0116370371210.1080/21645515.2019.16642411664241Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding proteinPeter T. Beernink0UCSF Benioff Children’s Hospital OaklandBacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen. Antibodies to FHbp can neutralize its function by inhibiting binding of FH to the bacteria and confer robust complement-mediated protection. However, in the presence of human or primate FH, antibodies to FHbp do not inhibit FH binding and the protective antibody responses are decreased. This immune suppression can be overcome by modification of the FHbp antigen to decrease FH binding, which modulates the antibody repertoire to inhibit FH binding and increase protection. When FHbp is present at sufficient density on the bacterial surface, two or more antibodies can synergize to activate the complement system. Thus, modification of FHbp antigens to decrease FH binding expands the anti-FHbp antibody repertoire and increases the potential for synergistic activity.http://dx.doi.org/10.1080/21645515.2019.1664241bactericidalcapsular group bfactor hfactor h binding proteinmeningococcal vaccinemenbmutantprotective antibody responsesstructure |
| spellingShingle | Peter T. Beernink Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein Human Vaccines & Immunotherapeutics bactericidal capsular group b factor h factor h binding protein meningococcal vaccine menb mutant protective antibody responses structure |
| title | Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein |
| title_full | Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein |
| title_fullStr | Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein |
| title_full_unstemmed | Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein |
| title_short | Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein |
| title_sort | effect of complement factor h on antibody repertoire and protection elicited by meningococcal capsular group b vaccines containing factor h binding protein |
| topic | bactericidal capsular group b factor h factor h binding protein meningococcal vaccine menb mutant protective antibody responses structure |
| url | http://dx.doi.org/10.1080/21645515.2019.1664241 |
| work_keys_str_mv | AT petertbeernink effectofcomplementfactorhonantibodyrepertoireandprotectionelicitedbymeningococcalcapsulargroupbvaccinescontainingfactorhbindingprotein |