Impact of Sarcopenia on Acute Kidney Injury after Infrarenal Abdominal Aortic Aneurysm Surgery: A Propensity Matching Analysis
Background: Sarcopenia contributes to increased morbidity and mortality in patients undergoing surgery for abdominal aortic aneurysms (AAA). However, few reports have demonstrated whether sarcopenia would affect the development of postoperative acute kidney injury (AKI) in these patients. This study...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/7/2212 |
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| author | Ji-Yeon Bang In-Gu Jun Jeong-Bok Lee You-Sun Ko Kyung-Won Kim Jun-Hyeop Jeong Sung-Hoon Kim Jun-Gol Song |
| author_facet | Ji-Yeon Bang In-Gu Jun Jeong-Bok Lee You-Sun Ko Kyung-Won Kim Jun-Hyeop Jeong Sung-Hoon Kim Jun-Gol Song |
| author_sort | Ji-Yeon Bang |
| collection | DOAJ |
| description | Background: Sarcopenia contributes to increased morbidity and mortality in patients undergoing surgery for abdominal aortic aneurysms (AAA). However, few reports have demonstrated whether sarcopenia would affect the development of postoperative acute kidney injury (AKI) in these patients. This study aimed to examine whether sarcopenia is associated with AKI and morbidity and mortality after infrarenal AAA operation. Methods: We retrospectively analysed 379 patients who underwent infrarenal AAA surgery. The diagnosis of sarcopenia was performed using the skeletal muscle index, which was calculated from axial computed tomography at the level of L3. The patients were separated into those with sarcopenia (<i>n</i> = 104) and those without sarcopenia (<i>n</i> = 275). We applied multivariable and Cox regression analyses to evaluate the risk factors for AKI and overall mortality. A propensity score matching (PSM) evaluation was done to assess the postoperative results. Results: The incidence of AKI was greater in sarcopenia than non-sarcopenia group before (34.6% vs. 15.3%; <i>p</i> < 0.001) and after the PSM analysis (34.6% vs. 15.4%; <i>p</i> = 0.002). Multivariable analysis revealed sarcopenia to be associated with AKI before (<i>p</i> = 0.010) and after PSM (<i>p</i> = 0.016). Sarcopenia was also associated with overall mortality before (<i>p</i> = 0.048) and after PSM (<i>p</i> = 0.032). A Kaplan–Meier analysis revealed that overall mortality was elevated patients with sarcopenia before and after PSM than in those without (log-rank test, <i>p</i> < 0.001, <i>p</i> = 0.022). Conclusions: Sarcopenia was associated with increased postoperative AKI incidence and overall mortality among individuals who underwent infrarenal AAA operation. |
| first_indexed | 2024-03-10T10:00:17Z |
| format | Article |
| id | doaj.art-0e00867793914fc9a71c532e76e25010 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T10:00:17Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0e00867793914fc9a71c532e76e250102023-11-22T01:57:47ZengMDPI AGNutrients2072-66432021-06-01137221210.3390/nu13072212Impact of Sarcopenia on Acute Kidney Injury after Infrarenal Abdominal Aortic Aneurysm Surgery: A Propensity Matching AnalysisJi-Yeon Bang0In-Gu Jun1Jeong-Bok Lee2You-Sun Ko3Kyung-Won Kim4Jun-Hyeop Jeong5Sung-Hoon Kim6Jun-Gol Song7Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Radiology, Asan Image Metrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Radiology, Asan Image Metrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaBackground: Sarcopenia contributes to increased morbidity and mortality in patients undergoing surgery for abdominal aortic aneurysms (AAA). However, few reports have demonstrated whether sarcopenia would affect the development of postoperative acute kidney injury (AKI) in these patients. This study aimed to examine whether sarcopenia is associated with AKI and morbidity and mortality after infrarenal AAA operation. Methods: We retrospectively analysed 379 patients who underwent infrarenal AAA surgery. The diagnosis of sarcopenia was performed using the skeletal muscle index, which was calculated from axial computed tomography at the level of L3. The patients were separated into those with sarcopenia (<i>n</i> = 104) and those without sarcopenia (<i>n</i> = 275). We applied multivariable and Cox regression analyses to evaluate the risk factors for AKI and overall mortality. A propensity score matching (PSM) evaluation was done to assess the postoperative results. Results: The incidence of AKI was greater in sarcopenia than non-sarcopenia group before (34.6% vs. 15.3%; <i>p</i> < 0.001) and after the PSM analysis (34.6% vs. 15.4%; <i>p</i> = 0.002). Multivariable analysis revealed sarcopenia to be associated with AKI before (<i>p</i> = 0.010) and after PSM (<i>p</i> = 0.016). Sarcopenia was also associated with overall mortality before (<i>p</i> = 0.048) and after PSM (<i>p</i> = 0.032). A Kaplan–Meier analysis revealed that overall mortality was elevated patients with sarcopenia before and after PSM than in those without (log-rank test, <i>p</i> < 0.001, <i>p</i> = 0.022). Conclusions: Sarcopenia was associated with increased postoperative AKI incidence and overall mortality among individuals who underwent infrarenal AAA operation.https://www.mdpi.com/2072-6643/13/7/2212sarcopeniaabdominal aortic aneurysmacute kidney injurypostoperative outcome |
| spellingShingle | Ji-Yeon Bang In-Gu Jun Jeong-Bok Lee You-Sun Ko Kyung-Won Kim Jun-Hyeop Jeong Sung-Hoon Kim Jun-Gol Song Impact of Sarcopenia on Acute Kidney Injury after Infrarenal Abdominal Aortic Aneurysm Surgery: A Propensity Matching Analysis Nutrients sarcopenia abdominal aortic aneurysm acute kidney injury postoperative outcome |
| title | Impact of Sarcopenia on Acute Kidney Injury after Infrarenal Abdominal Aortic Aneurysm Surgery: A Propensity Matching Analysis |
| title_full | Impact of Sarcopenia on Acute Kidney Injury after Infrarenal Abdominal Aortic Aneurysm Surgery: A Propensity Matching Analysis |
| title_fullStr | Impact of Sarcopenia on Acute Kidney Injury after Infrarenal Abdominal Aortic Aneurysm Surgery: A Propensity Matching Analysis |
| title_full_unstemmed | Impact of Sarcopenia on Acute Kidney Injury after Infrarenal Abdominal Aortic Aneurysm Surgery: A Propensity Matching Analysis |
| title_short | Impact of Sarcopenia on Acute Kidney Injury after Infrarenal Abdominal Aortic Aneurysm Surgery: A Propensity Matching Analysis |
| title_sort | impact of sarcopenia on acute kidney injury after infrarenal abdominal aortic aneurysm surgery a propensity matching analysis |
| topic | sarcopenia abdominal aortic aneurysm acute kidney injury postoperative outcome |
| url | https://www.mdpi.com/2072-6643/13/7/2212 |
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