Blood Lipid Disorders in Post-Operative Craniopharyngioma Children and Adolescents and the Improvement with Recombinant Human Growth Hormone Replacement
Han-Ze Du,1,* Kang Chen,1,* Li-Yuan Zhang,1,* Yue-Lun Zhang,2 Dan-Ning Wu,1 Xiao-Yuan Guo,1 Lian Duan,1 Lin-Jie Wang,1 Hong-Bo Yang,1 Shi Chen,1 Hui Pan,1 Hui-Juan Zhu1 1Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Labo...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-10-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/blood-lipid-disorders-in-post-operative-craniopharyngioma-children-and-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797659017661644800 |
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| author | Du HZ Chen K Zhang LY Zhang YL Wu DN Guo XY Duan L Wang LJ Yang HB Chen S Pan H Zhu HJ |
| author_facet | Du HZ Chen K Zhang LY Zhang YL Wu DN Guo XY Duan L Wang LJ Yang HB Chen S Pan H Zhu HJ |
| author_sort | Du HZ |
| collection | DOAJ |
| description | Han-Ze Du,1,* Kang Chen,1,* Li-Yuan Zhang,1,* Yue-Lun Zhang,2 Dan-Ning Wu,1 Xiao-Yuan Guo,1 Lian Duan,1 Lin-Jie Wang,1 Hong-Bo Yang,1 Shi Chen,1 Hui Pan,1 Hui-Juan Zhu1 1Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, People’s Republic of China; 2Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Pan; Hui-Juan Zhu, Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing Street, Dongcheng District, Beijing, 100730, People’s Republic of China, Email panhui20111111@163.com; shengxin2004@163.comContext: The high prevalence of hypothalamic obesity (HO) and dyslipidemia in individuals with craniopharyngioma (CP) following surgery is a cause for increasing concern. However, few studies have explored the lipid profile in pediatric CP patients, with inconsistent findings. In addition, the role of recombinant human growth hormone (rhGH) replacement remains unclear in these patients.Objective: To compare the blood lipid profile among post-operative craniopharyngioma children and adolescents with that among healthy controls and to reveal the effects of rhGH replacement.Methods: Data of 79 post-operative craniopharyngioma children and adolescents in our center were retrospectively collected. Sixty patients underwent rhGH replacement during the follow-ups. We selected 36 patients who received rhGH replacement therapy, while 20 patients received rhGH replacement for at least 1 year and had complete lipid data before and after treatment and compared them with 19 patients who did not receive rhGH replacement therapy.Results: Craniopharyngioma patients had higher total cholesterol (TC) (5.17 vs 3.77 mmol/L), triglyceride (TG) (1.51 vs 0.73 mmol/L), and low-density lipoprotein cholesterol (LDL-C) (3.14 vs 2.10 mmol/L), and lower high-density lipoprotein cholesterol (HDL-C) (1.06 vs 1.39 mmol/L) than controls (all p < 0.001). The lipid profile of obese and non-obese patients was not significantly different. After rhGH replacement, TC was 0.90 mmol/L lower (p = 0.002) and LDL-C was 0.73 mmol/L lower (p = 0.010) than baseline. Although the baseline LDL-C was higher, patients with rhGH replacement had lower LDL-C (− 0.73 mmol/L adjusted for age and sex, p = 0.045) after the initiation of replacement compared with patients without rhGH replacement.Conclusion: The lipid profile of obese and non-obese children and adolescents with craniopharyngioma was unfavorable, and rhGH replacement could improve their lipid profile.Keywords: craniopharyngioma, dyslipidemias, obesity, human growth hormone, hypothalamic obesity |
| first_indexed | 2024-03-11T18:07:54Z |
| format | Article |
| id | doaj.art-0e01a632afd340dc841c8e38c206c5e7 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-11T18:07:54Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-0e01a632afd340dc841c8e38c206c5e72023-10-17T02:42:29ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-10-01Volume 163075308487119Blood Lipid Disorders in Post-Operative Craniopharyngioma Children and Adolescents and the Improvement with Recombinant Human Growth Hormone ReplacementDu HZChen KZhang LYZhang YLWu DNGuo XYDuan LWang LJYang HBChen SPan HZhu HJHan-Ze Du,1,* Kang Chen,1,* Li-Yuan Zhang,1,* Yue-Lun Zhang,2 Dan-Ning Wu,1 Xiao-Yuan Guo,1 Lian Duan,1 Lin-Jie Wang,1 Hong-Bo Yang,1 Shi Chen,1 Hui Pan,1 Hui-Juan Zhu1 1Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, People’s Republic of China; 2Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Pan; Hui-Juan Zhu, Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing Street, Dongcheng District, Beijing, 100730, People’s Republic of China, Email panhui20111111@163.com; shengxin2004@163.comContext: The high prevalence of hypothalamic obesity (HO) and dyslipidemia in individuals with craniopharyngioma (CP) following surgery is a cause for increasing concern. However, few studies have explored the lipid profile in pediatric CP patients, with inconsistent findings. In addition, the role of recombinant human growth hormone (rhGH) replacement remains unclear in these patients.Objective: To compare the blood lipid profile among post-operative craniopharyngioma children and adolescents with that among healthy controls and to reveal the effects of rhGH replacement.Methods: Data of 79 post-operative craniopharyngioma children and adolescents in our center were retrospectively collected. Sixty patients underwent rhGH replacement during the follow-ups. We selected 36 patients who received rhGH replacement therapy, while 20 patients received rhGH replacement for at least 1 year and had complete lipid data before and after treatment and compared them with 19 patients who did not receive rhGH replacement therapy.Results: Craniopharyngioma patients had higher total cholesterol (TC) (5.17 vs 3.77 mmol/L), triglyceride (TG) (1.51 vs 0.73 mmol/L), and low-density lipoprotein cholesterol (LDL-C) (3.14 vs 2.10 mmol/L), and lower high-density lipoprotein cholesterol (HDL-C) (1.06 vs 1.39 mmol/L) than controls (all p < 0.001). The lipid profile of obese and non-obese patients was not significantly different. After rhGH replacement, TC was 0.90 mmol/L lower (p = 0.002) and LDL-C was 0.73 mmol/L lower (p = 0.010) than baseline. Although the baseline LDL-C was higher, patients with rhGH replacement had lower LDL-C (− 0.73 mmol/L adjusted for age and sex, p = 0.045) after the initiation of replacement compared with patients without rhGH replacement.Conclusion: The lipid profile of obese and non-obese children and adolescents with craniopharyngioma was unfavorable, and rhGH replacement could improve their lipid profile.Keywords: craniopharyngioma, dyslipidemias, obesity, human growth hormone, hypothalamic obesityhttps://www.dovepress.com/blood-lipid-disorders-in-post-operative-craniopharyngioma-children-and-peer-reviewed-fulltext-article-DMSOcraniopharyngiomadyslipidemiasobesityhuman growth hormonehypothalamic obesity |
| spellingShingle | Du HZ Chen K Zhang LY Zhang YL Wu DN Guo XY Duan L Wang LJ Yang HB Chen S Pan H Zhu HJ Blood Lipid Disorders in Post-Operative Craniopharyngioma Children and Adolescents and the Improvement with Recombinant Human Growth Hormone Replacement Diabetes, Metabolic Syndrome and Obesity craniopharyngioma dyslipidemias obesity human growth hormone hypothalamic obesity |
| title | Blood Lipid Disorders in Post-Operative Craniopharyngioma Children and Adolescents and the Improvement with Recombinant Human Growth Hormone Replacement |
| title_full | Blood Lipid Disorders in Post-Operative Craniopharyngioma Children and Adolescents and the Improvement with Recombinant Human Growth Hormone Replacement |
| title_fullStr | Blood Lipid Disorders in Post-Operative Craniopharyngioma Children and Adolescents and the Improvement with Recombinant Human Growth Hormone Replacement |
| title_full_unstemmed | Blood Lipid Disorders in Post-Operative Craniopharyngioma Children and Adolescents and the Improvement with Recombinant Human Growth Hormone Replacement |
| title_short | Blood Lipid Disorders in Post-Operative Craniopharyngioma Children and Adolescents and the Improvement with Recombinant Human Growth Hormone Replacement |
| title_sort | blood lipid disorders in post operative craniopharyngioma children and adolescents and the improvement with recombinant human growth hormone replacement |
| topic | craniopharyngioma dyslipidemias obesity human growth hormone hypothalamic obesity |
| url | https://www.dovepress.com/blood-lipid-disorders-in-post-operative-craniopharyngioma-children-and-peer-reviewed-fulltext-article-DMSO |
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