Repurposing of the Antiepileptic Drug Levetiracetam to Restrain Neuroendocrine Prostate Cancer and Inhibit Mast Cell Support to Adenocarcinoma

Repurposing of the Antiepileptic Drug Levetiracetam to Restrain Neuroendocrine Prostate Cancer and Inhibit Mast Cell Support to Adenocarcinoma

A relevant fraction of castration-resistant prostate cancers (CRPC) evolve into fatal neuroendocrine (NEPC) tumors in resistance to androgen deprivation and/or inhibitors of androgen receptor pathway. Therefore, effective drugs against both CRPC and NEPC are needed. We have previously described a du...

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Bibliographic Details
Main Authors: Roberta Sulsenti, Barbara Frossi, Lucia Bongiovanni, Valeria Cancila, Paola Ostano, Irene Fischetti, Claudia Enriquez, Francesca Guana, Giovanna Chiorino, Claudio Tripodo, Carlo E. Pucillo, Mario P. Colombo, Elena Jachetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
prostate cancer
neuroendocrine differentiation
mast cells
drug repurposing
tumor microenvironment
mouse models
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.622001/full

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