Crocins for Ischemic Stroke: A Review of Current Evidence
Crocins (CRs) and the related active constituents derived from Crocus sativus L. (Saffron) have demonstrated protective effects against cerebral ischemia and ischemic stroke, with various bioactivities including neuroprotection, anti-neuroinflammation, antioxidant, and cardiovascular protection. Amo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.825842/full |
| _version_ | 1811221134426767360 |
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| author | Kiran Shahbaz Dennis Chang Xian Zhou Mitchell Low Sai Wang Seto Sai Wang Seto Sai Wang Seto Chung Guang Li |
| author_facet | Kiran Shahbaz Dennis Chang Xian Zhou Mitchell Low Sai Wang Seto Sai Wang Seto Sai Wang Seto Chung Guang Li |
| author_sort | Kiran Shahbaz |
| collection | DOAJ |
| description | Crocins (CRs) and the related active constituents derived from Crocus sativus L. (Saffron) have demonstrated protective effects against cerebral ischemia and ischemic stroke, with various bioactivities including neuroprotection, anti-neuroinflammation, antioxidant, and cardiovascular protection. Among CRs, crocin (CR) has been shown to act on multiple mechanisms and signaling pathways involved in ischemic stroke, including mitochondrial apoptosis, nuclear factor kappa light chain enhancer of B cells pathway, S100 calcium-binding protein B, interleukin-6 and vascular endothelial growth factor-A. CR is generally safe and well-tolerated. Pharmacokinetic studies indicate that CR has poor bioavailability and needs to convert to crocetin (CC) in order to cross the blood-brain barrier. Clinical studies have shown the efficacy of saffron and CR in treating various conditions, including metabolic syndrome, depression, Alzheimer’s disease, and coronary artery disease. There is evidence supporting CR as a treatment for ischemic stroke, although further studies are needed to confirm their efficacy and safety in clinical settings. |
| first_indexed | 2024-04-12T07:54:04Z |
| format | Article |
| id | doaj.art-0e02d0fa7d534cd1896b726e9989e51a |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T07:54:04Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0e02d0fa7d534cd1896b726e9989e51a2022-12-22T03:41:32ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.825842825842Crocins for Ischemic Stroke: A Review of Current EvidenceKiran Shahbaz0Dennis Chang1Xian Zhou2Mitchell Low3Sai Wang Seto4Sai Wang Seto5Sai Wang Seto6Chung Guang Li7NICM Health Research Institute, Western Sydney University, Penrith, NSW, AustraliaNICM Health Research Institute, Western Sydney University, Penrith, NSW, AustraliaNICM Health Research Institute, Western Sydney University, Penrith, NSW, AustraliaNICM Health Research Institute, Western Sydney University, Penrith, NSW, AustraliaNICM Health Research Institute, Western Sydney University, Penrith, NSW, AustraliaReserach Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, ChinaDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, ChinaNICM Health Research Institute, Western Sydney University, Penrith, NSW, AustraliaCrocins (CRs) and the related active constituents derived from Crocus sativus L. (Saffron) have demonstrated protective effects against cerebral ischemia and ischemic stroke, with various bioactivities including neuroprotection, anti-neuroinflammation, antioxidant, and cardiovascular protection. Among CRs, crocin (CR) has been shown to act on multiple mechanisms and signaling pathways involved in ischemic stroke, including mitochondrial apoptosis, nuclear factor kappa light chain enhancer of B cells pathway, S100 calcium-binding protein B, interleukin-6 and vascular endothelial growth factor-A. CR is generally safe and well-tolerated. Pharmacokinetic studies indicate that CR has poor bioavailability and needs to convert to crocetin (CC) in order to cross the blood-brain barrier. Clinical studies have shown the efficacy of saffron and CR in treating various conditions, including metabolic syndrome, depression, Alzheimer’s disease, and coronary artery disease. There is evidence supporting CR as a treatment for ischemic stroke, although further studies are needed to confirm their efficacy and safety in clinical settings.https://www.frontiersin.org/articles/10.3389/fphar.2022.825842/fullischemic strokeCrocinssaffronneuroinflammationantioxidantmolecular targets |
| spellingShingle | Kiran Shahbaz Dennis Chang Xian Zhou Mitchell Low Sai Wang Seto Sai Wang Seto Sai Wang Seto Chung Guang Li Crocins for Ischemic Stroke: A Review of Current Evidence Frontiers in Pharmacology ischemic stroke Crocins saffron neuroinflammation antioxidant molecular targets |
| title | Crocins for Ischemic Stroke: A Review of Current Evidence |
| title_full | Crocins for Ischemic Stroke: A Review of Current Evidence |
| title_fullStr | Crocins for Ischemic Stroke: A Review of Current Evidence |
| title_full_unstemmed | Crocins for Ischemic Stroke: A Review of Current Evidence |
| title_short | Crocins for Ischemic Stroke: A Review of Current Evidence |
| title_sort | crocins for ischemic stroke a review of current evidence |
| topic | ischemic stroke Crocins saffron neuroinflammation antioxidant molecular targets |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.825842/full |
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