A preliminary histological study, in an experimental murine model, of gastritis induction, compared to the protective effect of a biological preparation
Peptic ulcer disease is a chronic condition that affects a significant number of people worldwide, estimated at approximately 10% of the global population. This is the result of an imbalance between aggressive factors, such as gastric juice and its increased acidity, and the defense mechanisms of th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Romanian National Association of the Veterinary Products Manufacturers
2023-12-01
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| Series: | Medicamentul Veterinar |
| Subjects: | |
| Online Access: | http://www.veterinarypharmacon.com/docs/2616-2023_VD_17(2)_ART.8.ENG.pdf |
| _version_ | 1797390258907643904 |
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| author | Sergiu Orășan - Alic Diana Brezovan Eugenia Dumitrescu Florin Muselin Mihai Folescu Daiana Ionela Cocos Alexandru O. Doma Romeo T. Cristina |
| author_facet | Sergiu Orășan - Alic Diana Brezovan Eugenia Dumitrescu Florin Muselin Mihai Folescu Daiana Ionela Cocos Alexandru O. Doma Romeo T. Cristina |
| author_sort | Sergiu Orășan - Alic |
| collection | DOAJ |
| description | Peptic ulcer disease is a chronic condition that affects a significant number of people worldwide, estimated at approximately 10% of the global population. This is the result of an imbalance between aggressive factors, such as gastric juice and its increased acidity, and the defense mechanisms of the lining of the stomach and small intestine. Aspects such as exposure to certain substances or infection with bacteria such as Helicobacter pylori (H. pylori) are considered triggers in the development of peptic ulcers. Risk
factors include frequent use of non-steroidal anti-inflammatory drugs (NSAIDs) and high levels of stress. Conventional treatments for peptic ulcers include proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists, which are effective in decreasing gastric acid secretion. However, these treatments may be associated with side effects and may lead to recurrences or unwanted interactions with other medications. In contrast, natural approaches and complementary therapies have gained popularity in the management and treatment of peptic ulcers. Medicinal plants and their active compounds have been recognized for their anti-inflammatory and protective properties of the stomach lining. Some plants such as Curcuma longa or Angelica keiskei have been studied for their potential to reduce inflammation and promote ulcer healing, as well as other natural preparations such as royal jelly or propolis, derived from beekeeping. For example, royal Jelly is known for its anti-inflammatory and antimicrobial properties, which can help reduce irritation of the gastric mucosa and heal ulcers. Angelica keiskei, with its active compounds, has demonstrated the ability to protect the mucosa and reduce the excessive production of gastric acid. Turmeric, rich in curcumin, is another ingredient studied for its anti-inflammatory and antioxidant effects, which may support healing and reduce peptic ulcer symptoms. |
| first_indexed | 2024-03-08T23:09:06Z |
| format | Article |
| id | doaj.art-0e034e50e13b4e7ca312254880adf7b1 |
| institution | Directory Open Access Journal |
| issn | 1843-9527 2069-2463 |
| language | English |
| last_indexed | 2024-03-08T23:09:06Z |
| publishDate | 2023-12-01 |
| publisher | Romanian National Association of the Veterinary Products Manufacturers |
| record_format | Article |
| series | Medicamentul Veterinar |
| spelling | doaj.art-0e034e50e13b4e7ca312254880adf7b12023-12-15T08:46:25ZengRomanian National Association of the Veterinary Products ManufacturersMedicamentul Veterinar1843-95272069-24632023-12-011728494A preliminary histological study, in an experimental murine model, of gastritis induction, compared to the protective effect of a biological preparationSergiu Orășan - Alic 0Diana Brezovan1Eugenia Dumitrescu2Florin Muselin3Mihai Folescu4Daiana Ionela Cocos5Alexandru O. Doma6Romeo T. Cristina7Faculty of Veterinary Medicine TimisoaraFaculty of Veterinary Medicine TimisoaraFaculty of Veterinary Medicine TimisoaraFaculty of Veterinary Medicine TimisoaraFaculty of Veterinary Medicine TimisoaraFaculty of Veterinary Medicine TimisoaraFaculty of Veterinary Medicine TimisoaraFaculty of Veterinary Medicine TimisoaraPeptic ulcer disease is a chronic condition that affects a significant number of people worldwide, estimated at approximately 10% of the global population. This is the result of an imbalance between aggressive factors, such as gastric juice and its increased acidity, and the defense mechanisms of the lining of the stomach and small intestine. Aspects such as exposure to certain substances or infection with bacteria such as Helicobacter pylori (H. pylori) are considered triggers in the development of peptic ulcers. Risk factors include frequent use of non-steroidal anti-inflammatory drugs (NSAIDs) and high levels of stress. Conventional treatments for peptic ulcers include proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists, which are effective in decreasing gastric acid secretion. However, these treatments may be associated with side effects and may lead to recurrences or unwanted interactions with other medications. In contrast, natural approaches and complementary therapies have gained popularity in the management and treatment of peptic ulcers. Medicinal plants and their active compounds have been recognized for their anti-inflammatory and protective properties of the stomach lining. Some plants such as Curcuma longa or Angelica keiskei have been studied for their potential to reduce inflammation and promote ulcer healing, as well as other natural preparations such as royal jelly or propolis, derived from beekeeping. For example, royal Jelly is known for its anti-inflammatory and antimicrobial properties, which can help reduce irritation of the gastric mucosa and heal ulcers. Angelica keiskei, with its active compounds, has demonstrated the ability to protect the mucosa and reduce the excessive production of gastric acid. Turmeric, rich in curcumin, is another ingredient studied for its anti-inflammatory and antioxidant effects, which may support healing and reduce peptic ulcer symptoms. http://www.veterinarypharmacon.com/docs/2616-2023_VD_17(2)_ART.8.ENG.pdfphytotherapypeptic ulcerinduced gastritis |
| spellingShingle | Sergiu Orășan - Alic Diana Brezovan Eugenia Dumitrescu Florin Muselin Mihai Folescu Daiana Ionela Cocos Alexandru O. Doma Romeo T. Cristina A preliminary histological study, in an experimental murine model, of gastritis induction, compared to the protective effect of a biological preparation Medicamentul Veterinar phytotherapy peptic ulcer induced gastritis |
| title | A preliminary histological study, in an experimental murine model, of gastritis induction, compared to the protective effect of a biological preparation |
| title_full | A preliminary histological study, in an experimental murine model, of gastritis induction, compared to the protective effect of a biological preparation |
| title_fullStr | A preliminary histological study, in an experimental murine model, of gastritis induction, compared to the protective effect of a biological preparation |
| title_full_unstemmed | A preliminary histological study, in an experimental murine model, of gastritis induction, compared to the protective effect of a biological preparation |
| title_short | A preliminary histological study, in an experimental murine model, of gastritis induction, compared to the protective effect of a biological preparation |
| title_sort | preliminary histological study in an experimental murine model of gastritis induction compared to the protective effect of a biological preparation |
| topic | phytotherapy peptic ulcer induced gastritis |
| url | http://www.veterinarypharmacon.com/docs/2616-2023_VD_17(2)_ART.8.ENG.pdf |
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