Effect of anatomical location (mandible vs maxilla) of dental implants on the BMP-2, BMP-7, sRANKL and OPG levels in periimplant crevicular fluid during osseointegration. A pilot study
Background:The aim of this study was to investigate levels of bone morphogenetic protein-2 (BMP-2), BMP-7, soluble receptor activator of nuclear factor-kB ligand (sRANKL) and osteoprotegerin (OPG) in the peri-implant crevicular fluid (PICF) of implants placed in both maxilla and mandible during the...
| Hlavní autoři: | , , , , , , |
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| Médium: | Článek |
| Jazyk: | English |
| Vydáno: |
Selcuk University Press
2019-12-01
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| Edice: | Selcuk Dental Journal |
| Témata: | |
| On-line přístup: | https://dergipark.org.tr/tr/download/article-file/887758 |
| _version_ | 1826906701995966464 |
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| author | Mehmet Sağlam Doğan Dolanmaz Emrah Koçak Burcu Poyraz Özgür İnan Niyazi Dündar Sema Hakkı |
| author_facet | Mehmet Sağlam Doğan Dolanmaz Emrah Koçak Burcu Poyraz Özgür İnan Niyazi Dündar Sema Hakkı |
| author_sort | Mehmet Sağlam |
| collection | DOAJ |
| description | Background:The aim of this study was to investigate
levels of bone morphogenetic protein-2 (BMP-2), BMP-7, soluble receptor
activator of nuclear factor-kB ligand (sRANKL) and osteoprotegerin (OPG) in the
peri-implant crevicular fluid (PICF) of implants placed in both maxilla and mandible
during the osseointegration period.Methods:Thirty-three patients (17 females and 16
males; mean age 47.03±11.23 years) were included in this study. A total of 33
implants were placed in both of maxilla (Group 1/n=18) and mandible (group
2/n=15). Peri-implant
crevicular fluid (PICF) samples, modified plaque index (MPI), gingival index
(GI) and probing depth (PD) measurements were obtained at 1 and 3 months after
surgery. PICF levels of BMP-2/-7, sRANKL and OPG were analyzed by ELISA.Results:No complications were observed during
the healing period. No significant differences were observed in the PICF
levels of sRANKL, OPG, BMP-2 and BMP-7 and evaluated clinical parameters between
groups at any time point (p>0.05). While PICF volume of group 2 was greater
than group 1 at first month, PICF volume of group 1 was greater than group 2 at
3 months (p<0.05). There was a positive correlation between sRANKL
levels and PICF volume (p<0.05) and a strong correlation between BMP-2 and
BMP-7 (p<0.01).Conclusions:The results of this pilot study didn’t
show any significant difference in PICF levels of BMP-2, BMP-7, sRANKL, and OPG
in terms of anatomic location of dental implants. Further well-designed studies should be carried
out to evaluate the relationship between bone related biomarkers and anatomic
location of dental implants. |
| first_indexed | 2024-03-11T10:34:13Z |
| format | Article |
| id | doaj.art-0e037f9fc1ff47bd989068ebe26a5054 |
| institution | Directory Open Access Journal |
| issn | 2148-7529 |
| language | English |
| last_indexed | 2025-02-17T08:51:37Z |
| publishDate | 2019-12-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Selcuk Dental Journal |
| spelling | doaj.art-0e037f9fc1ff47bd989068ebe26a50542025-01-02T19:51:22ZengSelcuk University PressSelcuk Dental Journal2148-75292019-12-016326127010.15311/selcukdentj.450292154Effect of anatomical location (mandible vs maxilla) of dental implants on the BMP-2, BMP-7, sRANKL and OPG levels in periimplant crevicular fluid during osseointegration. A pilot studyMehmet SağlamDoğan DolanmazEmrah KoçakBurcu PoyrazÖzgür İnanNiyazi DündarSema HakkıBackground:The aim of this study was to investigate levels of bone morphogenetic protein-2 (BMP-2), BMP-7, soluble receptor activator of nuclear factor-kB ligand (sRANKL) and osteoprotegerin (OPG) in the peri-implant crevicular fluid (PICF) of implants placed in both maxilla and mandible during the osseointegration period.Methods:Thirty-three patients (17 females and 16 males; mean age 47.03±11.23 years) were included in this study. A total of 33 implants were placed in both of maxilla (Group 1/n=18) and mandible (group 2/n=15). Peri-implant crevicular fluid (PICF) samples, modified plaque index (MPI), gingival index (GI) and probing depth (PD) measurements were obtained at 1 and 3 months after surgery. PICF levels of BMP-2/-7, sRANKL and OPG were analyzed by ELISA.Results:No complications were observed during the healing period. No significant differences were observed in the PICF levels of sRANKL, OPG, BMP-2 and BMP-7 and evaluated clinical parameters between groups at any time point (p>0.05). While PICF volume of group 2 was greater than group 1 at first month, PICF volume of group 1 was greater than group 2 at 3 months (p<0.05). There was a positive correlation between sRANKL levels and PICF volume (p<0.05) and a strong correlation between BMP-2 and BMP-7 (p<0.01).Conclusions:The results of this pilot study didn’t show any significant difference in PICF levels of BMP-2, BMP-7, sRANKL, and OPG in terms of anatomic location of dental implants. Further well-designed studies should be carried out to evaluate the relationship between bone related biomarkers and anatomic location of dental implants.https://dergipark.org.tr/tr/download/article-file/887758bone morphogenetic proteinsdental implantosteoprotegerinreceptor activator of nuclear factor-kappa bkemik morfogenetik proteinleridental implantosteoprotegrinreseptör aktivatör nükleer kappa b ligand |
| spellingShingle | Mehmet Sağlam Doğan Dolanmaz Emrah Koçak Burcu Poyraz Özgür İnan Niyazi Dündar Sema Hakkı Effect of anatomical location (mandible vs maxilla) of dental implants on the BMP-2, BMP-7, sRANKL and OPG levels in periimplant crevicular fluid during osseointegration. A pilot study Selcuk Dental Journal bone morphogenetic proteins dental implant osteoprotegerin receptor activator of nuclear factor-kappa b kemik morfogenetik proteinleri dental implant osteoprotegrin reseptör aktivatör nükleer kappa b ligand |
| title | Effect of anatomical location (mandible vs maxilla) of dental implants on the BMP-2, BMP-7, sRANKL and OPG levels in periimplant crevicular fluid during osseointegration. A pilot study |
| title_full | Effect of anatomical location (mandible vs maxilla) of dental implants on the BMP-2, BMP-7, sRANKL and OPG levels in periimplant crevicular fluid during osseointegration. A pilot study |
| title_fullStr | Effect of anatomical location (mandible vs maxilla) of dental implants on the BMP-2, BMP-7, sRANKL and OPG levels in periimplant crevicular fluid during osseointegration. A pilot study |
| title_full_unstemmed | Effect of anatomical location (mandible vs maxilla) of dental implants on the BMP-2, BMP-7, sRANKL and OPG levels in periimplant crevicular fluid during osseointegration. A pilot study |
| title_short | Effect of anatomical location (mandible vs maxilla) of dental implants on the BMP-2, BMP-7, sRANKL and OPG levels in periimplant crevicular fluid during osseointegration. A pilot study |
| title_sort | effect of anatomical location mandible vs maxilla of dental implants on the bmp 2 bmp 7 srankl and opg levels in periimplant crevicular fluid during osseointegration a pilot study |
| topic | bone morphogenetic proteins dental implant osteoprotegerin receptor activator of nuclear factor-kappa b kemik morfogenetik proteinleri dental implant osteoprotegrin reseptör aktivatör nükleer kappa b ligand |
| url | https://dergipark.org.tr/tr/download/article-file/887758 |
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