Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications
Abstract Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place a heavy financial strain on both patients and the global healthcare establishment. The lack of effective treatments contributes to this pessimistic situation and ne...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-04-01
|
| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-024-06659-w |
| _version_ | 1797199102400790528 |
|---|---|
| author | Yu-Rui Jiao Kai-Xuan Chen Xiang Tang Yu-Long Tang Hai-Lin Yang Yu-Long Yin Chang-Jun Li |
| author_facet | Yu-Rui Jiao Kai-Xuan Chen Xiang Tang Yu-Long Tang Hai-Lin Yang Yu-Long Yin Chang-Jun Li |
| author_sort | Yu-Rui Jiao |
| collection | DOAJ |
| description | Abstract Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place a heavy financial strain on both patients and the global healthcare establishment. The lack of effective treatments contributes to this pessimistic situation and negative outlook. Exosomes released from mesenchymal stromal cells (MSCs) have emerged as the most likely new breakthrough and advancement in treating of diabetes and diabetes‐associated complication due to its capacity of intercellular communication, modulating the local microenvironment, and regulating cellular processes. In the present review, we briefly outlined the properties of MSCs-derived exosomes, provided a thorough summary of their biological functions and potential uses in diabetes and its related complications. |
| first_indexed | 2024-04-24T07:10:25Z |
| format | Article |
| id | doaj.art-0e04653fac3f49339ea01dbeaabf1639 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-24T07:10:25Z |
| publishDate | 2024-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-0e04653fac3f49339ea01dbeaabf16392024-04-21T11:32:04ZengNature Publishing GroupCell Death and Disease2041-48892024-04-0115412210.1038/s41419-024-06659-wExosomes derived from mesenchymal stem cells in diabetes and diabetic complicationsYu-Rui Jiao0Kai-Xuan Chen1Xiang Tang2Yu-Long Tang3Hai-Lin Yang4Yu-Long Yin5Chang-Jun Li6Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South UniversityDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South UniversityDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South UniversityKey Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of SciencesDepartment of Orthopaedics, The Second Affiliated Hospital of Fuyang Normal UniversityKey Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of SciencesDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South UniversityAbstract Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place a heavy financial strain on both patients and the global healthcare establishment. The lack of effective treatments contributes to this pessimistic situation and negative outlook. Exosomes released from mesenchymal stromal cells (MSCs) have emerged as the most likely new breakthrough and advancement in treating of diabetes and diabetes‐associated complication due to its capacity of intercellular communication, modulating the local microenvironment, and regulating cellular processes. In the present review, we briefly outlined the properties of MSCs-derived exosomes, provided a thorough summary of their biological functions and potential uses in diabetes and its related complications.https://doi.org/10.1038/s41419-024-06659-w |
| spellingShingle | Yu-Rui Jiao Kai-Xuan Chen Xiang Tang Yu-Long Tang Hai-Lin Yang Yu-Long Yin Chang-Jun Li Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications Cell Death and Disease |
| title | Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications |
| title_full | Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications |
| title_fullStr | Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications |
| title_full_unstemmed | Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications |
| title_short | Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications |
| title_sort | exosomes derived from mesenchymal stem cells in diabetes and diabetic complications |
| url | https://doi.org/10.1038/s41419-024-06659-w |
| work_keys_str_mv | AT yuruijiao exosomesderivedfrommesenchymalstemcellsindiabetesanddiabeticcomplications AT kaixuanchen exosomesderivedfrommesenchymalstemcellsindiabetesanddiabeticcomplications AT xiangtang exosomesderivedfrommesenchymalstemcellsindiabetesanddiabeticcomplications AT yulongtang exosomesderivedfrommesenchymalstemcellsindiabetesanddiabeticcomplications AT hailinyang exosomesderivedfrommesenchymalstemcellsindiabetesanddiabeticcomplications AT yulongyin exosomesderivedfrommesenchymalstemcellsindiabetesanddiabeticcomplications AT changjunli exosomesderivedfrommesenchymalstemcellsindiabetesanddiabeticcomplications |