Use of Biolayer Interferometry to Identify Dominant Binding Epitopes of Influenza Hemagglutinin Protein of A(H1N1)pdm09 in the Antibody Response to 2010–2011 Influenza Seasonal Vaccine

Use of Biolayer Interferometry to Identify Dominant Binding Epitopes of Influenza Hemagglutinin Protein of A(H1N1)pdm09 in the Antibody Response to 2010–2011 Influenza Seasonal Vaccine

The globular head domain of influenza virus surface protein hemagglutinin (HA1) is the major target of neutralizing antibodies elicited by vaccines. As little as one amino acid substitution in the HA1 can result in an antigenic drift of influenza viruses, indicating the dominance of some epitopes in...

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Bibliographic Details
Main Authors: Zhu Guo, Xiuhua Lu, Paul J. Carney, Jessie Chang, Wen-pin Tzeng, Ian A. York, Min Z. Levine, James Stevens
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Vaccines
Subjects:
influenza vaccine
humoral response
dominant binding epitope
Online Access:https://www.mdpi.com/2076-393X/11/8/1307

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