Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis

Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis

Interferon regulatory factor 4 (IRF4) is a master transcription factor that regulates T helper cell (Th) differentiation. It interacts with the Basic leucine zipper transcription factor, ATF-like (BATF), depletion of which in CD4+ T cells abrogates acute graft-versus-host disease (aGVHD)-induced col...

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Main Authors: Jochen T. Frueh, Julia Campe, Daniele Yumi Sunaga-Franze, Nikita A. Verheyden, Sakhila Ghimire, Elisabeth Meedt, Denise Haslinger, Sabine Harenkamp, Daniel Staudenraus, Sascha Sauer, Andreas Kreft, Ralf Schubert, Michael Lohoff, Andreas Krueger, Halvard Bonig, Andreas G. Chiocchetti, Robert Zeiser, Ernst Holler, Evelyn Ullrich
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Acute GVHD
BACH2
IRF4
T helper cells
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2296712

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