4,5-Dihydro-5-Oxo-Pyrazolo[1,5-a]Thieno[2,3-c]Pyrimidine: A Novel Scaffold Containing Thiophene Ring. Chemical Reactivity and In Silico Studies to Predict the Profile to GABA<sub>A</sub> Receptor Subtype

4,5-Dihydro-5-Oxo-Pyrazolo[1,5-a]Thieno[2,3-c]Pyrimidine: A Novel Scaffold Containing Thiophene Ring. Chemical Reactivity and In Silico Studies to Predict the Profile to GABA<sub>A</sub> Receptor Subtype

The isosteric replacement of the benzene with thiophene ring is a chemical modification widely applied in medicinal chemistry. Several drugs containing the thiophene ring are marketed for treating various pathologies (osteoporosis, peripheral artery disorder, psychosis, anxiety and convulsion). Taki...

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Bibliographic Details
Main Authors: Letizia Crocetti, Gabriella Guerrini, Fabrizio Melani, Claudia Vergelli, Maria Paola Giovannoni
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
4,5-dihydro-5-oxo-pyrazolo[1,5-a]thieno[2,3-c]pyrimidines
novel scaffold
thiophene
molecular dynamic studies
proximity frequencies (PF)
GABA<sub>A</sub> receptor subtype
Online Access:https://www.mdpi.com/1420-3049/28/7/3054

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https://www.mdpi.com/1420-3049/28/7/3054

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