An elevated serum level of endothelial monocyte activating polypeptide-II in patients with arterial hypertension with and without type 2 diabetes and obesity
Objectives: To assess serum levels of endothelial monocyte activating polypeptide-II (EMAP-II) in patients with arterial hypertension with and without type 2 diabetes mellitus and obesity.Materials and methods: We examined 41 hypertensive patients with type 2 diabetes, 18 obese hypertensive patients...
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Endocrinology Research Centre
2016-11-01
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Series: | Ожирение и метаболизм |
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Online Access: | https://www.omet-endojournals.ru/jour/article/view/7823 |
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author | Liliya Mogylnytska Boris Mankovsky |
author_facet | Liliya Mogylnytska Boris Mankovsky |
author_sort | Liliya Mogylnytska |
collection | DOAJ |
description | Objectives: To assess serum levels of endothelial monocyte activating polypeptide-II (EMAP-II) in patients with arterial hypertension with and without type 2 diabetes mellitus and obesity.Materials and methods: We examined 41 hypertensive patients with type 2 diabetes, 18 obese hypertensive patients without diabetes, 9 non-obese hypertensive patients without diabetes, and 18 healthy control subjects.Results: We found an increased serum level of EMAP-II in hypertensive patients with type 2 diabetes compared to controls (4.86±2.3 and 1.08±0.53 ng/ml respectively, р<0.01), in hypertensive patients with obesity (2.92±1.42 ng/ml) compared to controls, and in non-obese hypertensive patients (2.02±0.33 ng/ml) compared to controls. Also, the levels of EMAP-II significantly correlated with HbA1c, blood glucose, serum insulin levels, HOMA, lipids, and body mass index (р<0.01).Conclusions: The revealed changes could reflect an endothelial dysfunction mostly pronounced in patients with arterial hypertension, type 2 diabetes mellitus and obesity. Hyperglycemia, dyslipidemia, insulin resistance, obesity appear to be significant contributing factors leading to the elevation of EMAP-II. |
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institution | Directory Open Access Journal |
issn | 2071-8713 2306-5524 |
language | English |
last_indexed | 2024-04-24T08:37:28Z |
publishDate | 2016-11-01 |
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record_format | Article |
series | Ожирение и метаболизм |
spelling | doaj.art-0e064e6ce9de435e9af2acaccbec4e4a2024-04-16T16:16:10ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242016-11-01133495310.14341/omet2016349-537415An elevated serum level of endothelial monocyte activating polypeptide-II in patients with arterial hypertension with and without type 2 diabetes and obesityLiliya Mogylnytska0Boris Mankovsky1Khmelnytsky regional hospital, UkraineP.L. Shupyk National Medical Academy of Postgraduate EducationObjectives: To assess serum levels of endothelial monocyte activating polypeptide-II (EMAP-II) in patients with arterial hypertension with and without type 2 diabetes mellitus and obesity.Materials and methods: We examined 41 hypertensive patients with type 2 diabetes, 18 obese hypertensive patients without diabetes, 9 non-obese hypertensive patients without diabetes, and 18 healthy control subjects.Results: We found an increased serum level of EMAP-II in hypertensive patients with type 2 diabetes compared to controls (4.86±2.3 and 1.08±0.53 ng/ml respectively, р<0.01), in hypertensive patients with obesity (2.92±1.42 ng/ml) compared to controls, and in non-obese hypertensive patients (2.02±0.33 ng/ml) compared to controls. Also, the levels of EMAP-II significantly correlated with HbA1c, blood glucose, serum insulin levels, HOMA, lipids, and body mass index (р<0.01).Conclusions: The revealed changes could reflect an endothelial dysfunction mostly pronounced in patients with arterial hypertension, type 2 diabetes mellitus and obesity. Hyperglycemia, dyslipidemia, insulin resistance, obesity appear to be significant contributing factors leading to the elevation of EMAP-II.https://www.omet-endojournals.ru/jour/article/view/7823endothelial monocyte activating polypeptide iiemap-ii, endothelial dysfunctionarterial hypertensiontype 2 diabetesobesity |
spellingShingle | Liliya Mogylnytska Boris Mankovsky An elevated serum level of endothelial monocyte activating polypeptide-II in patients with arterial hypertension with and without type 2 diabetes and obesity Ожирение и метаболизм endothelial monocyte activating polypeptide ii emap-ii, endothelial dysfunction arterial hypertension type 2 diabetes obesity |
title | An elevated serum level of endothelial monocyte activating polypeptide-II in patients with arterial hypertension with and without type 2 diabetes and obesity |
title_full | An elevated serum level of endothelial monocyte activating polypeptide-II in patients with arterial hypertension with and without type 2 diabetes and obesity |
title_fullStr | An elevated serum level of endothelial monocyte activating polypeptide-II in patients with arterial hypertension with and without type 2 diabetes and obesity |
title_full_unstemmed | An elevated serum level of endothelial monocyte activating polypeptide-II in patients with arterial hypertension with and without type 2 diabetes and obesity |
title_short | An elevated serum level of endothelial monocyte activating polypeptide-II in patients with arterial hypertension with and without type 2 diabetes and obesity |
title_sort | elevated serum level of endothelial monocyte activating polypeptide ii in patients with arterial hypertension with and without type 2 diabetes and obesity |
topic | endothelial monocyte activating polypeptide ii emap-ii, endothelial dysfunction arterial hypertension type 2 diabetes obesity |
url | https://www.omet-endojournals.ru/jour/article/view/7823 |
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