Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity
Partial cation substitution can significantly change the physical properties of parent compounds. By controlling the chemical composition and knowing the mutual relationship between composition and physical properties, it is possible to tailor the properties of materials to those that are superior f...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/5/870 |
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| author | Miloš Ognjanović Željko Jaćimović Milica Kosović-Perutović Irina Besu Žižak Tatjana Stanojković Željko Žižak Biljana Dojčinović Dalibor M. Stanković Bratislav Antić |
| author_facet | Miloš Ognjanović Željko Jaćimović Milica Kosović-Perutović Irina Besu Žižak Tatjana Stanojković Željko Žižak Biljana Dojčinović Dalibor M. Stanković Bratislav Antić |
| author_sort | Miloš Ognjanović |
| collection | DOAJ |
| description | Partial cation substitution can significantly change the physical properties of parent compounds. By controlling the chemical composition and knowing the mutual relationship between composition and physical properties, it is possible to tailor the properties of materials to those that are superior for desired technological application. Using the polyol synthesis procedure, a series of yttrium-substituted iron oxide nanoconstructs, γ-Fe<sub>2−<i>x</i></sub>Y<i><sub>x</sub></i>O<sub>3</sub> (YIONs), was prepared. It was found that Y<sup>3+</sup> could substitute Fe<sup>3+</sup> in the crystal structures of maghemite (γ-Fe<sub>2</sub>O<sub>3</sub>) up to a limited concentration of ~1.5% (γ-Fe<sub>1.969</sub>Y<sub>0.031</sub>O<sub>3</sub>). Analysis of TEM micrographs showed that crystallites or particles were aggregated in flower-like structures with diameters from 53.7 ± 6.2 nm to 97.3 ± 37.0 nm, depending on yttrium concentration. To be investigated for potential applications as magnetic hyperthermia agents, YIONs were tested twice: their heating efficiency was tested and their toxicity was investigated. The Specific Absorption Rate (<i>SAR</i>) values were in the range of 32.6 W/g to 513 W/g and significantly decreased with increased yttrium concentration in the samples. Intrinsic loss power (<i>ILP</i>) for γ-Fe<sub>2</sub>O<sub>3</sub> and γ-Fe<sub>1.995</sub>Y<sub>0.005</sub>O<sub>3</sub> were ~8–9 nH·m<sup>2</sup>/Kg, which pointed to their excellent heating efficiency. IC<sub>50</sub> values of investigated samples against cancer (HeLa) and normal (MRC-5) cells decreased with increased yttrium concentration and were higher than ~300 μg/mL. The samples of γ-Fe<sub>2−<i>x</i></sub>Y<i><sub>x</sub></i>O<sub>3</sub> did not show a genotoxic effect. The results of toxicity studies show that YIONs are suitable for further in vitro/in vivo studies toward to their potential medical applications, while results of heat generation point to their potential use in magnetic hyperthermia cancer treatment or use as self-heating systems for other technological applications such as catalysis. |
| first_indexed | 2024-03-11T07:15:12Z |
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| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-11T07:15:12Z |
| publishDate | 2023-02-01 |
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| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-0e069637a6184eb8bec8cf8b992b8fb92023-11-17T08:17:39ZengMDPI AGNanomaterials2079-49912023-02-0113587010.3390/nano13050870Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and GenotoxicityMiloš Ognjanović0Željko Jaćimović1Milica Kosović-Perutović2Irina Besu Žižak3Tatjana Stanojković4Željko Žižak5Biljana Dojčinović6Dalibor M. Stanković7Bratislav Antić8VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovića Alasa 12-14, 11000 Belgrade, SerbiaFaculty of Metallurgy and Technology, University of Montenegro, Cetinjski put bb, 81000 Podgorica, MontenegroFaculty of Metallurgy and Technology, University of Montenegro, Cetinjski put bb, 81000 Podgorica, MontenegroInstitute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, SerbiaInstitute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, SerbiaInstitute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, SerbiaInstitute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, Njegoševa 12, 11000 Belgrade, SerbiaVINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovića Alasa 12-14, 11000 Belgrade, SerbiaVINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovića Alasa 12-14, 11000 Belgrade, SerbiaPartial cation substitution can significantly change the physical properties of parent compounds. By controlling the chemical composition and knowing the mutual relationship between composition and physical properties, it is possible to tailor the properties of materials to those that are superior for desired technological application. Using the polyol synthesis procedure, a series of yttrium-substituted iron oxide nanoconstructs, γ-Fe<sub>2−<i>x</i></sub>Y<i><sub>x</sub></i>O<sub>3</sub> (YIONs), was prepared. It was found that Y<sup>3+</sup> could substitute Fe<sup>3+</sup> in the crystal structures of maghemite (γ-Fe<sub>2</sub>O<sub>3</sub>) up to a limited concentration of ~1.5% (γ-Fe<sub>1.969</sub>Y<sub>0.031</sub>O<sub>3</sub>). Analysis of TEM micrographs showed that crystallites or particles were aggregated in flower-like structures with diameters from 53.7 ± 6.2 nm to 97.3 ± 37.0 nm, depending on yttrium concentration. To be investigated for potential applications as magnetic hyperthermia agents, YIONs were tested twice: their heating efficiency was tested and their toxicity was investigated. The Specific Absorption Rate (<i>SAR</i>) values were in the range of 32.6 W/g to 513 W/g and significantly decreased with increased yttrium concentration in the samples. Intrinsic loss power (<i>ILP</i>) for γ-Fe<sub>2</sub>O<sub>3</sub> and γ-Fe<sub>1.995</sub>Y<sub>0.005</sub>O<sub>3</sub> were ~8–9 nH·m<sup>2</sup>/Kg, which pointed to their excellent heating efficiency. IC<sub>50</sub> values of investigated samples against cancer (HeLa) and normal (MRC-5) cells decreased with increased yttrium concentration and were higher than ~300 μg/mL. The samples of γ-Fe<sub>2−<i>x</i></sub>Y<i><sub>x</sub></i>O<sub>3</sub> did not show a genotoxic effect. The results of toxicity studies show that YIONs are suitable for further in vitro/in vivo studies toward to their potential medical applications, while results of heat generation point to their potential use in magnetic hyperthermia cancer treatment or use as self-heating systems for other technological applications such as catalysis.https://www.mdpi.com/2079-4991/13/5/870magnetic nanoparticlespolyol synthesismagnetic hyperthermiacytotoxicitycomet assay |
| spellingShingle | Miloš Ognjanović Željko Jaćimović Milica Kosović-Perutović Irina Besu Žižak Tatjana Stanojković Željko Žižak Biljana Dojčinović Dalibor M. Stanković Bratislav Antić Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity Nanomaterials magnetic nanoparticles polyol synthesis magnetic hyperthermia cytotoxicity comet assay |
| title | Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity |
| title_full | Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity |
| title_fullStr | Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity |
| title_full_unstemmed | Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity |
| title_short | Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity |
| title_sort | self heating flower like nanoconstructs with limited incorporation of yttrium in maghemite effect of chemical composition on heating efficiency cytotoxicity and genotoxicity |
| topic | magnetic nanoparticles polyol synthesis magnetic hyperthermia cytotoxicity comet assay |
| url | https://www.mdpi.com/2079-4991/13/5/870 |
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