Analytical method (HPLC), validation used for identification and assay of the pharmaceutical active ingredient, Tylosin tartrate for veterinary use and its finite product Tilodem 50, hydrosoluble powder
In SC DELOS IMPEX ’96 SRL the quality of the active pharmaceutical ingredient (API) for the finite product Tilodem 50 - hydrosoluble powder was acomkplished in the respect of last European Pharmacopoeia.The method for analysis used in this purpose was the compendial method „Tylosin tartrate for vete...
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| Format: | Article |
| Language: | English |
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Romanian National Association of the Veterinary Products Manufacturers
2010-12-01
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| Series: | Medicamentul Veterinar |
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| Online Access: | http://www.veterinarypharmacon.com/docs/609-2010-%20ART.6.pdf |
| _version_ | 1829471759678570496 |
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| author | Maria Neagu |
| author_facet | Maria Neagu |
| author_sort | Maria Neagu |
| collection | DOAJ |
| description | In SC DELOS IMPEX ’96 SRL the quality of the active pharmaceutical ingredient (API) for the finite product Tilodem 50 - hydrosoluble powder was acomkplished in the respect of last European Pharmacopoeia.The method for analysis used in this purpose was the compendial method „Tylosin tartrate for veterinary use” in EurPh. in vigour edition and represent a variant developed and validation „in house”.The parameters which was included in the methodology validation for chromatographic method are the followings: Selectivity, Linearity, Linearity range, Detection and Quantification limits, Precision, Repeatability (intra day), Inter-Day Reproductibility, Accuracy, Robustness, Solutions’ stability and System suitability. According to the European Pharmacopoeia, the active pharmaceutical ingredient is consistent, in terms of quality, if it contains Tylosin A - minimum 80% and the amount of Tylosin A, B, C, D, at minimum 95%. Identification and determination of each component separately (Tylosin A, B, C, D) is possible by chromatographic separation-HPLC. Validation of analytical methods is presented below. |
| first_indexed | 2024-12-14T02:02:15Z |
| format | Article |
| id | doaj.art-0e071f3020564ae19a5198edfa29efca |
| institution | Directory Open Access Journal |
| issn | 1843-9527 2069-2463 |
| language | English |
| last_indexed | 2024-12-14T02:02:15Z |
| publishDate | 2010-12-01 |
| publisher | Romanian National Association of the Veterinary Products Manufacturers |
| record_format | Article |
| series | Medicamentul Veterinar |
| spelling | doaj.art-0e071f3020564ae19a5198edfa29efca2022-12-21T23:20:58ZengRomanian National Association of the Veterinary Products ManufacturersMedicamentul Veterinar1843-95272069-24632010-12-01424765Analytical method (HPLC), validation used for identification and assay of the pharmaceutical active ingredient, Tylosin tartrate for veterinary use and its finite product Tilodem 50, hydrosoluble powderMaria NeaguIn SC DELOS IMPEX ’96 SRL the quality of the active pharmaceutical ingredient (API) for the finite product Tilodem 50 - hydrosoluble powder was acomkplished in the respect of last European Pharmacopoeia.The method for analysis used in this purpose was the compendial method „Tylosin tartrate for veterinary use” in EurPh. in vigour edition and represent a variant developed and validation „in house”.The parameters which was included in the methodology validation for chromatographic method are the followings: Selectivity, Linearity, Linearity range, Detection and Quantification limits, Precision, Repeatability (intra day), Inter-Day Reproductibility, Accuracy, Robustness, Solutions’ stability and System suitability. According to the European Pharmacopoeia, the active pharmaceutical ingredient is consistent, in terms of quality, if it contains Tylosin A - minimum 80% and the amount of Tylosin A, B, C, D, at minimum 95%. Identification and determination of each component separately (Tylosin A, B, C, D) is possible by chromatographic separation-HPLC. Validation of analytical methods is presented below.http://www.veterinarypharmacon.com/docs/609-2010-%20ART.6.pdfTylosin tartrate a.u.v.validation (HPLC)identificationassay. |
| spellingShingle | Maria Neagu Analytical method (HPLC), validation used for identification and assay of the pharmaceutical active ingredient, Tylosin tartrate for veterinary use and its finite product Tilodem 50, hydrosoluble powder Medicamentul Veterinar Tylosin tartrate a.u.v. validation (HPLC) identification assay. |
| title | Analytical method (HPLC), validation used for identification and assay of the pharmaceutical active ingredient, Tylosin tartrate for veterinary use and its finite product Tilodem 50, hydrosoluble powder |
| title_full | Analytical method (HPLC), validation used for identification and assay of the pharmaceutical active ingredient, Tylosin tartrate for veterinary use and its finite product Tilodem 50, hydrosoluble powder |
| title_fullStr | Analytical method (HPLC), validation used for identification and assay of the pharmaceutical active ingredient, Tylosin tartrate for veterinary use and its finite product Tilodem 50, hydrosoluble powder |
| title_full_unstemmed | Analytical method (HPLC), validation used for identification and assay of the pharmaceutical active ingredient, Tylosin tartrate for veterinary use and its finite product Tilodem 50, hydrosoluble powder |
| title_short | Analytical method (HPLC), validation used for identification and assay of the pharmaceutical active ingredient, Tylosin tartrate for veterinary use and its finite product Tilodem 50, hydrosoluble powder |
| title_sort | analytical method hplc validation used for identification and assay of the pharmaceutical active ingredient tylosin tartrate for veterinary use and its finite product tilodem 50 hydrosoluble powder |
| topic | Tylosin tartrate a.u.v. validation (HPLC) identification assay. |
| url | http://www.veterinarypharmacon.com/docs/609-2010-%20ART.6.pdf |
| work_keys_str_mv | AT marianeagu analyticalmethodhplcvalidationusedforidentificationandassayofthepharmaceuticalactiveingredienttylosintartrateforveterinaryuseanditsfiniteproducttilodem50hydrosolublepowder |