The implications of Vitamin E acetate in E-cigarette, or vaping, product use-associated lung injury
In the summer of 2019, a cluster of cases were observed with users of battery-operated or superheating devices presenting with multiple symptoms, such as dyspnea, cough, fever, constitutional symptoms, gastrointestinal upset, and hemoptysis, that is now termed e-cigarette, or vaping, product use-ass...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Annals of Thoracic Medicine |
| Subjects: | |
| Online Access: | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2023;volume=18;issue=1;spage=1;epage=9;aulast=Soto |
| _version_ | 1828014142702747648 |
|---|---|
| author | Brian Soto Louis Costanzo Anoop Puskoor Nada Akkari Patrick Geraghty |
| author_facet | Brian Soto Louis Costanzo Anoop Puskoor Nada Akkari Patrick Geraghty |
| author_sort | Brian Soto |
| collection | DOAJ |
| description | In the summer of 2019, a cluster of cases were observed with users of battery-operated or superheating devices presenting with multiple symptoms, such as dyspnea, cough, fever, constitutional symptoms, gastrointestinal upset, and hemoptysis, that is now termed e-cigarette, or vaping, product use-associated lung injury (EVALI). The Centers for Disease Control and Prevention reported 2807 cases within the USA leading to at least 68 deaths as of February 18, 2020. The heterogeneous presentations of EVALI make diagnosis and treatment difficult; however, treatment focused on identifying and removal of the noxious substance and providing supportive care. Vitamin E acetate (VEA) is a likely cause of this lung injury, and others have reported other components to play a possible role, such as nicotine and vegetable glycerin/propylene glycol. EVALI is usually observed in adolescents, with a history of vaping product usage within 90 days typically containing tetrahydrocannabinol, and presenting on chest radiograph with pulmonary infiltrates or computed tomography scan with ground-glass opacities. Diagnosis requires a high degree of suspicion to diagnose and exclusion of other possible causes of lung disease. Here, we review the current literature to detail the major factors contributing to EVALI and primarily discuss the potential role of VEA in EVALI. We will also briefly discuss other constituents other than just VEA, as a small number of EVALI cases are reported without the detection of VEA, but with the same clinical diagnosis. |
| first_indexed | 2024-04-10T09:57:15Z |
| format | Article |
| id | doaj.art-0e09446fe2484a28b39236996d654f59 |
| institution | Directory Open Access Journal |
| issn | 1817-1737 1998-3557 |
| language | English |
| last_indexed | 2024-04-10T09:57:15Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Thoracic Medicine |
| spelling | doaj.art-0e09446fe2484a28b39236996d654f592023-02-16T12:02:55ZengWolters Kluwer Medknow PublicationsAnnals of Thoracic Medicine1817-17371998-35572023-01-011811910.4103/atm.atm_144_22The implications of Vitamin E acetate in E-cigarette, or vaping, product use-associated lung injuryBrian SotoLouis CostanzoAnoop PuskoorNada AkkariPatrick GeraghtyIn the summer of 2019, a cluster of cases were observed with users of battery-operated or superheating devices presenting with multiple symptoms, such as dyspnea, cough, fever, constitutional symptoms, gastrointestinal upset, and hemoptysis, that is now termed e-cigarette, or vaping, product use-associated lung injury (EVALI). The Centers for Disease Control and Prevention reported 2807 cases within the USA leading to at least 68 deaths as of February 18, 2020. The heterogeneous presentations of EVALI make diagnosis and treatment difficult; however, treatment focused on identifying and removal of the noxious substance and providing supportive care. Vitamin E acetate (VEA) is a likely cause of this lung injury, and others have reported other components to play a possible role, such as nicotine and vegetable glycerin/propylene glycol. EVALI is usually observed in adolescents, with a history of vaping product usage within 90 days typically containing tetrahydrocannabinol, and presenting on chest radiograph with pulmonary infiltrates or computed tomography scan with ground-glass opacities. Diagnosis requires a high degree of suspicion to diagnose and exclusion of other possible causes of lung disease. Here, we review the current literature to detail the major factors contributing to EVALI and primarily discuss the potential role of VEA in EVALI. We will also briefly discuss other constituents other than just VEA, as a small number of EVALI cases are reported without the detection of VEA, but with the same clinical diagnosis.http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2023;volume=18;issue=1;spage=1;epage=9;aulast=Sotoe-cigaretteor vapingproduct use-associated lung injurylung injuryvapingvitamin e acetate |
| spellingShingle | Brian Soto Louis Costanzo Anoop Puskoor Nada Akkari Patrick Geraghty The implications of Vitamin E acetate in E-cigarette, or vaping, product use-associated lung injury Annals of Thoracic Medicine e-cigarette or vaping product use-associated lung injury lung injury vaping vitamin e acetate |
| title | The implications of Vitamin E acetate in E-cigarette, or vaping, product use-associated lung injury |
| title_full | The implications of Vitamin E acetate in E-cigarette, or vaping, product use-associated lung injury |
| title_fullStr | The implications of Vitamin E acetate in E-cigarette, or vaping, product use-associated lung injury |
| title_full_unstemmed | The implications of Vitamin E acetate in E-cigarette, or vaping, product use-associated lung injury |
| title_short | The implications of Vitamin E acetate in E-cigarette, or vaping, product use-associated lung injury |
| title_sort | implications of vitamin e acetate in e cigarette or vaping product use associated lung injury |
| topic | e-cigarette or vaping product use-associated lung injury lung injury vaping vitamin e acetate |
| url | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2023;volume=18;issue=1;spage=1;epage=9;aulast=Soto |
| work_keys_str_mv | AT briansoto theimplicationsofvitamineacetateinecigaretteorvapingproductuseassociatedlunginjury AT louiscostanzo theimplicationsofvitamineacetateinecigaretteorvapingproductuseassociatedlunginjury AT anooppuskoor theimplicationsofvitamineacetateinecigaretteorvapingproductuseassociatedlunginjury AT nadaakkari theimplicationsofvitamineacetateinecigaretteorvapingproductuseassociatedlunginjury AT patrickgeraghty theimplicationsofvitamineacetateinecigaretteorvapingproductuseassociatedlunginjury AT briansoto implicationsofvitamineacetateinecigaretteorvapingproductuseassociatedlunginjury AT louiscostanzo implicationsofvitamineacetateinecigaretteorvapingproductuseassociatedlunginjury AT anooppuskoor implicationsofvitamineacetateinecigaretteorvapingproductuseassociatedlunginjury AT nadaakkari implicationsofvitamineacetateinecigaretteorvapingproductuseassociatedlunginjury AT patrickgeraghty implicationsofvitamineacetateinecigaretteorvapingproductuseassociatedlunginjury |