Methodological Challenges of Digital PCR Detection of the Histone H3 K27M Somatic Variant in Cerebrospinal Fluid

Methodological Challenges of Digital PCR Detection of the Histone H3 K27M Somatic Variant in Cerebrospinal Fluid

Cell-free DNA (cfDNA) in body fluids is invaluable for cancer diagnostics. Despite the impressive potential of liquid biopsies for the diagnostics of central nervous system (CNS) tumors, a number of challenges prevent introducing this approach into routine laboratory practice. In this study, we adop...

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Bibliographic Details
Main Authors: Margarita Zaytseva, Natalia Usman, Ekaterina Salnikova, Agunda Sanakoeva, Andge Valiakhmetova, Almira Chervova, Ludmila Papusha, Galina Novichkova, Alexander Druy
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Pathology and Oncology Research
Subjects:
cerebrospinal fluid
liquid biopsy
dPCR
cell-free DNA
CNS tumor
diffuse midline glioma
Online Access:https://www.por-journal.com/articles/10.3389/pore.2022.1610024/full

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