Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR‐542‐5p
Abstract Formononetin exhibits anti‐neoplastic activities in specific types of cancers, such as colon carcinoma and breast cancer. Nevertheless, its role in suppressing gastric carcinoma (GC) growth and metastatic‐associated phenotypes has not been fully understood. Here, we demonstrated that formon...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-03-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/kjm2.12322 |
| _version_ | 1818620169968156672 |
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| author | Wei‐Song Wang Can‐Song Zhao |
| author_facet | Wei‐Song Wang Can‐Song Zhao |
| author_sort | Wei‐Song Wang |
| collection | DOAJ |
| description | Abstract Formononetin exhibits anti‐neoplastic activities in specific types of cancers, such as colon carcinoma and breast cancer. Nevertheless, its role in suppressing gastric carcinoma (GC) growth and metastatic‐associated phenotypes has not been fully understood. Here, we demonstrated that formononetin decreased the viability of GC cell line SGC‐7901 and MGC‐803. Furthermore, formononetin suppressed the migration and invasion abilities of GC cells. Consistent with the results in vitro, the anticancer effect of formononetin was verified using xenograft model. The expression of microRNA‐542‐5p (miR‐542‐5p), acted as an oncogene in many cancers, was identified to be upregulated in GC. Importantly, miR‐542‐5p might involve in formononetin exhibits anticancer activity in GC cells. Taken together, these results indicate that formononetin inhibits the growth and aggressiveness of GC cells in vitro and in vivo. |
| first_indexed | 2024-12-16T17:49:07Z |
| format | Article |
| id | doaj.art-0e0a71f672b148cda5f1b07b411c397e |
| institution | Directory Open Access Journal |
| issn | 1607-551X 2410-8650 |
| language | English |
| last_indexed | 2024-12-16T17:49:07Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-0e0a71f672b148cda5f1b07b411c397e2022-12-21T22:22:22ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502021-03-0137321522510.1002/kjm2.12322Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR‐542‐5pWei‐Song Wang0Can‐Song Zhao1Department of General Surgery Zhuji Central Hospital Zhuji ChinaDepartment of General Surgery Zhuji People's Hospital of Zhejiang Zhuji ChinaAbstract Formononetin exhibits anti‐neoplastic activities in specific types of cancers, such as colon carcinoma and breast cancer. Nevertheless, its role in suppressing gastric carcinoma (GC) growth and metastatic‐associated phenotypes has not been fully understood. Here, we demonstrated that formononetin decreased the viability of GC cell line SGC‐7901 and MGC‐803. Furthermore, formononetin suppressed the migration and invasion abilities of GC cells. Consistent with the results in vitro, the anticancer effect of formononetin was verified using xenograft model. The expression of microRNA‐542‐5p (miR‐542‐5p), acted as an oncogene in many cancers, was identified to be upregulated in GC. Importantly, miR‐542‐5p might involve in formononetin exhibits anticancer activity in GC cells. Taken together, these results indicate that formononetin inhibits the growth and aggressiveness of GC cells in vitro and in vivo.https://doi.org/10.1002/kjm2.12322formononetingastric carcinomainvasionmigrationmiR‐542‐5p |
| spellingShingle | Wei‐Song Wang Can‐Song Zhao Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR‐542‐5p Kaohsiung Journal of Medical Sciences formononetin gastric carcinoma invasion migration miR‐542‐5p |
| title | Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR‐542‐5p |
| title_full | Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR‐542‐5p |
| title_fullStr | Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR‐542‐5p |
| title_full_unstemmed | Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR‐542‐5p |
| title_short | Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR‐542‐5p |
| title_sort | formononetin exhibits anticancer activity in gastric carcinoma cell and regulating mir 542 5p |
| topic | formononetin gastric carcinoma invasion migration miR‐542‐5p |
| url | https://doi.org/10.1002/kjm2.12322 |
| work_keys_str_mv | AT weisongwang formononetinexhibitsanticanceractivityingastriccarcinomacellandregulatingmir5425p AT cansongzhao formononetinexhibitsanticanceractivityingastriccarcinomacellandregulatingmir5425p |