The role of macrophage subtypes and exosomes in immunomodulation
Abstract Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migration, development, and organization of the cells. There is mounting evidence that m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-022-00384-y |
| _version_ | 1811194950787792896 |
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| author | Abdulwahab Teflischi Gharavi Niloofar Asadi Hanjani Elaheh Movahed Mohammad Doroudian |
| author_facet | Abdulwahab Teflischi Gharavi Niloofar Asadi Hanjani Elaheh Movahed Mohammad Doroudian |
| author_sort | Abdulwahab Teflischi Gharavi |
| collection | DOAJ |
| description | Abstract Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migration, development, and organization of the cells. There is mounting evidence that macrophage polarization plays a key role in the initiation and development of a wide range of diseases. This study aims to give an overview of macrophage polarization, their different subtypes, and the importance of alternatively activated M2 macrophage and classically activated M1 macrophage in immune responses and pathological conditions. This review provides insight on the role of exosomes in M1/M2-like macrophage polarization and their potential as a promising therapeutic candidate. |
| first_indexed | 2024-04-12T00:34:52Z |
| format | Article |
| id | doaj.art-0e0c0a179d974221ba5f59941e0eda7c |
| institution | Directory Open Access Journal |
| issn | 1425-8153 1689-1392 |
| language | English |
| last_indexed | 2024-04-12T00:34:52Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-0e0c0a179d974221ba5f59941e0eda7c2022-12-22T03:55:10ZengBMCCellular & Molecular Biology Letters1425-81531689-13922022-10-0127111810.1186/s11658-022-00384-yThe role of macrophage subtypes and exosomes in immunomodulationAbdulwahab Teflischi Gharavi0Niloofar Asadi Hanjani1Elaheh Movahed2Mohammad Doroudian3Department of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi UniversityDepartment of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi UniversityWadsworth Center, New York State Department of HealthDepartment of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi UniversityAbstract Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migration, development, and organization of the cells. There is mounting evidence that macrophage polarization plays a key role in the initiation and development of a wide range of diseases. This study aims to give an overview of macrophage polarization, their different subtypes, and the importance of alternatively activated M2 macrophage and classically activated M1 macrophage in immune responses and pathological conditions. This review provides insight on the role of exosomes in M1/M2-like macrophage polarization and their potential as a promising therapeutic candidate.https://doi.org/10.1186/s11658-022-00384-yExosomesInflammationMacrophagesMacrophage polarization |
| spellingShingle | Abdulwahab Teflischi Gharavi Niloofar Asadi Hanjani Elaheh Movahed Mohammad Doroudian The role of macrophage subtypes and exosomes in immunomodulation Cellular & Molecular Biology Letters Exosomes Inflammation Macrophages Macrophage polarization |
| title | The role of macrophage subtypes and exosomes in immunomodulation |
| title_full | The role of macrophage subtypes and exosomes in immunomodulation |
| title_fullStr | The role of macrophage subtypes and exosomes in immunomodulation |
| title_full_unstemmed | The role of macrophage subtypes and exosomes in immunomodulation |
| title_short | The role of macrophage subtypes and exosomes in immunomodulation |
| title_sort | role of macrophage subtypes and exosomes in immunomodulation |
| topic | Exosomes Inflammation Macrophages Macrophage polarization |
| url | https://doi.org/10.1186/s11658-022-00384-y |
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