Facile Synthesis of Black Phosphorus Nanosheet@NaReF<sub>4</sub> Nanocomposites for Potential Bioimaging
Black phosphorus nanomaterials (BPN) have been well developed in tumor therapy. However, lack of diagnostic function limits the development of BPN in biomedicine. Lanthanide-doped nanoparticles are considered as versatile materials for fluorescence or magnetic resonance imaging. Integration of BPN w...
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MDPI AG
2022-09-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/19/3383 |
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| author | Dongya Wang Jingcan Qin Chuan Zhang Yuehua Li |
| author_facet | Dongya Wang Jingcan Qin Chuan Zhang Yuehua Li |
| author_sort | Dongya Wang |
| collection | DOAJ |
| description | Black phosphorus nanomaterials (BPN) have been well developed in tumor therapy. However, lack of diagnostic function limits the development of BPN in biomedicine. Lanthanide-doped nanoparticles are considered as versatile materials for fluorescence or magnetic resonance imaging. Integration of BPN with lanthanide-doped nanoparticles was rarely reported owing to the complex synthesis processes and poor modification effect. Herein, we report a simple and general method for synthesizing BPN@NaReF<sub>4</sub> (Re: Gd or Y, Yb, Er) nanocomposite. TEM and XRD characterization confirm efficient combination of BPN and NaGdF<sub>4</sub> or NaYF<sub>4</sub>:Yb,Er (18.2 mol %) after one-step mixing. The FTIR and XPS spectra were used to prove the generation of PO<sub>4</sub><sup>3</sup><sup>−</sup>-Gd and P-Gd coordination bonds and clarify ligand exchange mechanism. The anchored nanoparticles on BPN were stable and become hydrophilic. The prepared BPN@NaGdF<sub>4</sub> exhibit the signals of photoacoustic and magnetic resonance imaging. The obtained BPN@NaYF<sub>4</sub>:Yb,Er (18.2 mol %) have the potential in fluorescence bioimaging. We believe that this work will expand the applications of BPN in diagnosis and therapy together. |
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| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T21:21:24Z |
| publishDate | 2022-09-01 |
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| spelling | doaj.art-0e0c25d8fa8442deb8d487c8d70b8da52023-11-23T21:19:12ZengMDPI AGNanomaterials2079-49912022-09-011219338310.3390/nano12193383Facile Synthesis of Black Phosphorus Nanosheet@NaReF<sub>4</sub> Nanocomposites for Potential BioimagingDongya Wang0Jingcan Qin1Chuan Zhang2Yuehua Li3Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yi Shan Road, Shanghai 200233, ChinaDepartment of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yi Shan Road, Shanghai 200233, ChinaSchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, ChinaDepartment of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yi Shan Road, Shanghai 200233, ChinaBlack phosphorus nanomaterials (BPN) have been well developed in tumor therapy. However, lack of diagnostic function limits the development of BPN in biomedicine. Lanthanide-doped nanoparticles are considered as versatile materials for fluorescence or magnetic resonance imaging. Integration of BPN with lanthanide-doped nanoparticles was rarely reported owing to the complex synthesis processes and poor modification effect. Herein, we report a simple and general method for synthesizing BPN@NaReF<sub>4</sub> (Re: Gd or Y, Yb, Er) nanocomposite. TEM and XRD characterization confirm efficient combination of BPN and NaGdF<sub>4</sub> or NaYF<sub>4</sub>:Yb,Er (18.2 mol %) after one-step mixing. The FTIR and XPS spectra were used to prove the generation of PO<sub>4</sub><sup>3</sup><sup>−</sup>-Gd and P-Gd coordination bonds and clarify ligand exchange mechanism. The anchored nanoparticles on BPN were stable and become hydrophilic. The prepared BPN@NaGdF<sub>4</sub> exhibit the signals of photoacoustic and magnetic resonance imaging. The obtained BPN@NaYF<sub>4</sub>:Yb,Er (18.2 mol %) have the potential in fluorescence bioimaging. We believe that this work will expand the applications of BPN in diagnosis and therapy together.https://www.mdpi.com/2079-4991/12/19/3383black phosphorusrare-earth nanoparticlenanocompositesmagnetic resonance imagingphotoacoustic imaging |
| spellingShingle | Dongya Wang Jingcan Qin Chuan Zhang Yuehua Li Facile Synthesis of Black Phosphorus Nanosheet@NaReF<sub>4</sub> Nanocomposites for Potential Bioimaging Nanomaterials black phosphorus rare-earth nanoparticle nanocomposites magnetic resonance imaging photoacoustic imaging |
| title | Facile Synthesis of Black Phosphorus Nanosheet@NaReF<sub>4</sub> Nanocomposites for Potential Bioimaging |
| title_full | Facile Synthesis of Black Phosphorus Nanosheet@NaReF<sub>4</sub> Nanocomposites for Potential Bioimaging |
| title_fullStr | Facile Synthesis of Black Phosphorus Nanosheet@NaReF<sub>4</sub> Nanocomposites for Potential Bioimaging |
| title_full_unstemmed | Facile Synthesis of Black Phosphorus Nanosheet@NaReF<sub>4</sub> Nanocomposites for Potential Bioimaging |
| title_short | Facile Synthesis of Black Phosphorus Nanosheet@NaReF<sub>4</sub> Nanocomposites for Potential Bioimaging |
| title_sort | facile synthesis of black phosphorus nanosheet naref sub 4 sub nanocomposites for potential bioimaging |
| topic | black phosphorus rare-earth nanoparticle nanocomposites magnetic resonance imaging photoacoustic imaging |
| url | https://www.mdpi.com/2079-4991/12/19/3383 |
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