A bone-based 3D scaffold as an in-vitro model of microenvironment–DLBCL lymphoma cell interaction

A bone-based 3D scaffold as an in-vitro model of microenvironment–DLBCL lymphoma cell interaction

About 30% of patients with diffuse large B-cell lymphoma (DLBCL) relapse or exhibit refractory disease (r/r DLBCL) after first-line immunochemotherapy. Bone marrow (BM) involvement confers a dismal prognosis at diagnosis, likely due to the interaction between neoplastic cells and a complex tumor mic...

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Bibliographic Details
Main Authors: Jessica Ceccato, Maria Piazza, Marco Pizzi, Sabrina Manni, Francesco Piazza, Ilaria Caputo, Francesco Cinetto, Lorena Pisoni, Diletta Trojan, Riccardo Scarpa, Renato Zambello, Angelo Paolo Dei Tos, Livio Trentin, Gianpietro Semenzato, Fabrizio Vianello
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
diffuse B-cell lymphoma
scaffold
mesenchymal stroma cell
extracellular matrix
3D
organoid
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.947823/full

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