A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions" [version 1; referees: 2 approved]
Tomasetti and Vogelstein argued that 2/3 of human cancers are due to ‘bad luck’ and that “primary prevention measures [against cancer] are not likely to be very effective”. We demonstrate that their calculations for hepatocellular carcinomas overlooked a major subset of these cancers proven to be pr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2016-08-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/5-2044/v1 |
| _version_ | 1819182043711406080 |
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| author | Maxime Tarabichi Vincent Detours |
| author_facet | Maxime Tarabichi Vincent Detours |
| author_sort | Maxime Tarabichi |
| collection | DOAJ |
| description | Tomasetti and Vogelstein argued that 2/3 of human cancers are due to ‘bad luck’ and that “primary prevention measures [against cancer] are not likely to be very effective”. We demonstrate that their calculations for hepatocellular carcinomas overlooked a major subset of these cancers proven to be preventable through vaccination. The problem, which is not limited to hepatocellular carcinoma, arises from the general reliance of their analysis on average incidences in the United States and the omission of incidences in specific risk groups. |
| first_indexed | 2024-12-22T22:39:51Z |
| format | Article |
| id | doaj.art-0e10b4b01d0e483c92a80b580e2a0e38 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-22T22:39:51Z |
| publishDate | 2016-08-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-0e10b4b01d0e483c92a80b580e2a0e382022-12-21T18:10:12ZengF1000 Research LtdF1000Research2046-14022016-08-01510.12688/f1000research.9448.110176A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions" [version 1; referees: 2 approved]Maxime Tarabichi0Vincent Detours1IRIBHM, Université Libre de Bruxelles (ULB), Brussels, B-1070, BelgiumIRIBHM, Université Libre de Bruxelles (ULB), Brussels, B-1070, BelgiumTomasetti and Vogelstein argued that 2/3 of human cancers are due to ‘bad luck’ and that “primary prevention measures [against cancer] are not likely to be very effective”. We demonstrate that their calculations for hepatocellular carcinomas overlooked a major subset of these cancers proven to be preventable through vaccination. The problem, which is not limited to hepatocellular carcinoma, arises from the general reliance of their analysis on average incidences in the United States and the omission of incidences in specific risk groups.https://f1000research.com/articles/5-2044/v1Cancer TherapeuticsMethods for Diagnostic & Therapeutic StudiesPreventive Medicine |
| spellingShingle | Maxime Tarabichi Vincent Detours A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions" [version 1; referees: 2 approved] F1000Research Cancer Therapeutics Methods for Diagnostic & Therapeutic Studies Preventive Medicine |
| title | A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions" [version 1; referees: 2 approved] |
| title_full | A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions" [version 1; referees: 2 approved] |
| title_fullStr | A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions" [version 1; referees: 2 approved] |
| title_full_unstemmed | A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions" [version 1; referees: 2 approved] |
| title_short | A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions" [version 1; referees: 2 approved] |
| title_sort | research note regarding variation in cancer risk among tissues can be explained by the number of stem cell divisions version 1 referees 2 approved |
| topic | Cancer Therapeutics Methods for Diagnostic & Therapeutic Studies Preventive Medicine |
| url | https://f1000research.com/articles/5-2044/v1 |
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