A topical rectal douche product containing Q-Griffithsin does not disrupt the epithelial border or alter CD4+ cell distribution in the human rectal mucosa

A topical rectal douche product containing Q-Griffithsin does not disrupt the epithelial border or alter CD4+ cell distribution in the human rectal mucosa

Abstract To reduce HIV transmission, locally applied pre-exposure prophylaxis (PrEP) products for anorectal use will be important complements to oral and injectable PrEP products already available. It is critical to preserve an intact rectal epithelium and avoid an influx of mucosal HIV target cells...

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Bibliographic Details
Main Authors: Mathias Franzén Boger, Nora Benhach, Tyra Hasselrot, Rhonda M. Brand, Lisa C. Rohan, Lin Wang, Ian McGowan, Stacey Edick, Ken Ho, Leslie Meyn, Nobuyuki Matoba, Kenneth E. Palmer, Kristina Broliden, Annelie Tjernlund
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34107-w

Internet

https://doi.org/10.1038/s41598-023-34107-w

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