The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease
BackgroundEnterovirus causing hand-foot-mouth disease (HFMD) has been reported to be associated with the development of Kawasaki disease (KD), whereas the involvement of enterovirus in the clinical course of KD is uncertain. The aim of this study is to investigate the association between the clinica...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.968857/full |
| _version_ | 1818066408479653888 |
|---|---|
| author | Daisuke Shimizu Takayuki Hoshina Masaru Kawamura Masaru Kawamura Yoshie Tomita Yasufumi Hidaka Masumi Kojiro Jun Muneuchi Junji Kamizono Kenichiro Yamaguchi Yoshihisa Fujino Koichi Kusuhara |
| author_facet | Daisuke Shimizu Takayuki Hoshina Masaru Kawamura Masaru Kawamura Yoshie Tomita Yasufumi Hidaka Masumi Kojiro Jun Muneuchi Junji Kamizono Kenichiro Yamaguchi Yoshihisa Fujino Koichi Kusuhara |
| author_sort | Daisuke Shimizu |
| collection | DOAJ |
| description | BackgroundEnterovirus causing hand-foot-mouth disease (HFMD) has been reported to be associated with the development of Kawasaki disease (KD), whereas the involvement of enterovirus in the clinical course of KD is uncertain. The aim of this study is to investigate the association between the clinical course of KD and HFMD epidemics.MethodsThis study included 108 patients who developed KD during HFMD epidemic seasons (July and August) from 2010 to 2014 and who were initially treated with high-dose intravenous immunoglobulin (IVIG). A mean of ≥5.0 HFMD patients reported weekly from each sentinel medical facility was considered to represent a large HFMD epidemic. We compared the clinical characteristics of KD patients in summers of years with and without large HFMD epidemics.ResultsLarge HFMD epidemics occurred in 2011 and 2013. The number of KD patients in summer was the highest in 2011. The proportion of patients with resistance to the IVIG therapy in summers of years with the large epidemics (14%) was significantly lower than that in summers of other years (31%, P = 0.030), whereas the proportion of patients with coronary artery abnormalities did not differ to a statistically significant extent. The development of KD during large HFMD epidemics was significantly associated with a lower risk of resistance to the IVIG therapy (incidence rate ratio 0.92, P = 0.049).ConclusionPatients developing KD during large HFMD epidemic may have good responsiveness to IVIG. It is important to identify microbes from KD patients to predict responsiveness to IVIG therapy. |
| first_indexed | 2024-12-10T15:07:19Z |
| format | Article |
| id | doaj.art-0e1312cdcc38455e89439aec35fca7d5 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-10T15:07:19Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-0e1312cdcc38455e89439aec35fca7d52022-12-22T01:44:01ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-09-011010.3389/fped.2022.968857968857The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki diseaseDaisuke Shimizu0Takayuki Hoshina1Masaru Kawamura2Masaru Kawamura3Yoshie Tomita4Yasufumi Hidaka5Masumi Kojiro6Jun Muneuchi7Junji Kamizono8Kenichiro Yamaguchi9Yoshihisa Fujino10Koichi Kusuhara11Department of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, JapanDepartment of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, JapanDepartment of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, JapanDepartment of Pediatrics, National Hospital Organization Kokura Medical Center, Kitakyushu, JapanDepartment of Pediatrics, Kitakyushu Municipal Yahata Hospital, Kitakyushu, JapanDepartment of Pediatrics, Kitakyushu Municipal Medical Center, Kitakyushu, JapanDepartment of Pediatrics, Kitakyushu General Hospital, Kitakyushu, JapanDepartment of Pediatrics, Japan Community Health Care Organization Kyushu Hospital, Kitakyushu, JapanDepartment of Pediatrics, Kitakyushu Municipal Yahata Hospital, Kitakyushu, JapanDepartment of Pediatrics, National Hospital Organization Kokura Medical Center, Kitakyushu, JapanDepartment of Environmental Epidemiology, School of Medicine, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, Kitakyushu, JapanDepartment of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, JapanBackgroundEnterovirus causing hand-foot-mouth disease (HFMD) has been reported to be associated with the development of Kawasaki disease (KD), whereas the involvement of enterovirus in the clinical course of KD is uncertain. The aim of this study is to investigate the association between the clinical course of KD and HFMD epidemics.MethodsThis study included 108 patients who developed KD during HFMD epidemic seasons (July and August) from 2010 to 2014 and who were initially treated with high-dose intravenous immunoglobulin (IVIG). A mean of ≥5.0 HFMD patients reported weekly from each sentinel medical facility was considered to represent a large HFMD epidemic. We compared the clinical characteristics of KD patients in summers of years with and without large HFMD epidemics.ResultsLarge HFMD epidemics occurred in 2011 and 2013. The number of KD patients in summer was the highest in 2011. The proportion of patients with resistance to the IVIG therapy in summers of years with the large epidemics (14%) was significantly lower than that in summers of other years (31%, P = 0.030), whereas the proportion of patients with coronary artery abnormalities did not differ to a statistically significant extent. The development of KD during large HFMD epidemics was significantly associated with a lower risk of resistance to the IVIG therapy (incidence rate ratio 0.92, P = 0.049).ConclusionPatients developing KD during large HFMD epidemic may have good responsiveness to IVIG. It is important to identify microbes from KD patients to predict responsiveness to IVIG therapy.https://www.frontiersin.org/articles/10.3389/fped.2022.968857/fullKawasaki disease (KD)hand-foot-and-mouth disease (HFMD)enterovirus (EV)responsiveness to immunoglobulin therapynegative correlation |
| spellingShingle | Daisuke Shimizu Takayuki Hoshina Masaru Kawamura Masaru Kawamura Yoshie Tomita Yasufumi Hidaka Masumi Kojiro Jun Muneuchi Junji Kamizono Kenichiro Yamaguchi Yoshihisa Fujino Koichi Kusuhara The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease Frontiers in Pediatrics Kawasaki disease (KD) hand-foot-and-mouth disease (HFMD) enterovirus (EV) responsiveness to immunoglobulin therapy negative correlation |
| title | The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease |
| title_full | The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease |
| title_fullStr | The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease |
| title_full_unstemmed | The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease |
| title_short | The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease |
| title_sort | possible association between epidemics of hand foot and mouth disease and responsiveness to immunoglobulin therapy in kawasaki disease |
| topic | Kawasaki disease (KD) hand-foot-and-mouth disease (HFMD) enterovirus (EV) responsiveness to immunoglobulin therapy negative correlation |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.968857/full |
| work_keys_str_mv | AT daisukeshimizu thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT takayukihoshina thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT masarukawamura thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT masarukawamura thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT yoshietomita thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT yasufumihidaka thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT masumikojiro thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT junmuneuchi thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT junjikamizono thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT kenichiroyamaguchi thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT yoshihisafujino thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT koichikusuhara thepossibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT daisukeshimizu possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT takayukihoshina possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT masarukawamura possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT masarukawamura possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT yoshietomita possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT yasufumihidaka possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT masumikojiro possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT junmuneuchi possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT junjikamizono possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT kenichiroyamaguchi possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT yoshihisafujino possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease AT koichikusuhara possibleassociationbetweenepidemicsofhandfootandmouthdiseaseandresponsivenesstoimmunoglobulintherapyinkawasakidisease |