Anti-Fibrotic Effect of Natural Toxin Bee Venom on Animal Model of Unilateral Ureteral Obstruction
Progressive renal fibrosis is the final common pathway for all kidney diseases leading to chronic renal failure. Bee venom (BV) has been widely used as a traditional medicine for various diseases. However, the precise mechanism of BV in ameliorating the renal fibrosis is not fully understood. To inv...
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MDPI AG
2015-05-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/7/6/1917 |
| _version_ | 1811279887420358656 |
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| author | Hyun Jin An Kyung Hyun Kim Woo Ram Lee Jung Yeon Kim Sun Jae Lee Sok Cheon Pak Sang Mi Han Kwan Kyu Park |
| author_facet | Hyun Jin An Kyung Hyun Kim Woo Ram Lee Jung Yeon Kim Sun Jae Lee Sok Cheon Pak Sang Mi Han Kwan Kyu Park |
| author_sort | Hyun Jin An |
| collection | DOAJ |
| description | Progressive renal fibrosis is the final common pathway for all kidney diseases leading to chronic renal failure. Bee venom (BV) has been widely used as a traditional medicine for various diseases. However, the precise mechanism of BV in ameliorating the renal fibrosis is not fully understood. To investigate the therapeutic effects of BV against unilateral ureteral obstruction (UUO)-induced renal fibrosis, BV was given intraperitoneally after ureteral ligation. At seven days after UUO surgery, the kidney tissues were collected for protein analysis and histologic examination. Histological observation revealed that UUO induced a considerable increase in the number of infiltrated inflammatory cells. However, BV treatment markedly reduced these reactions compared with untreated UUO mice. The expression levels of TNF-α and IL-1β were significantly reduced in BV treated mice compared with UUO mice. In addition, treatment with BV significantly inhibited TGF-β1 and fibronectin expression in UUO mice. Moreover, the expression of α-SMA was markedly withdrawn after treatment with BV. These findings suggest that BV attenuates renal fibrosis and reduces inflammatory responses by suppression of multiple growth factor-mediated pro-fibrotic genes. In conclusion, BV may be a useful therapeutic agent for the prevention of fibrosis that characterizes progression of chronic kidney disease. |
| first_indexed | 2024-04-13T01:03:53Z |
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| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-13T01:03:53Z |
| publishDate | 2015-05-01 |
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| spelling | doaj.art-0e132b9cd32c45948ef28ab57f3e84872022-12-22T03:09:23ZengMDPI AGToxins2072-66512015-05-01761917192810.3390/toxins7061917toxins7061917Anti-Fibrotic Effect of Natural Toxin Bee Venom on Animal Model of Unilateral Ureteral ObstructionHyun Jin An0Kyung Hyun Kim1Woo Ram Lee2Jung Yeon Kim3Sun Jae Lee4Sok Cheon Pak5Sang Mi Han6Kwan Kyu Park7Department of Pathology, College of Medicine, Catholic University of Daegu, 3056-6, Daemyung-4-Dong, Nam-gu, Daegu 705-718, KoreaDepartment of Pathology, College of Medicine, Catholic University of Daegu, 3056-6, Daemyung-4-Dong, Nam-gu, Daegu 705-718, KoreaDepartment of Pathology, College of Medicine, Catholic University of Daegu, 3056-6, Daemyung-4-Dong, Nam-gu, Daegu 705-718, KoreaDepartment of Pathology, College of Medicine, Catholic University of Daegu, 3056-6, Daemyung-4-Dong, Nam-gu, Daegu 705-718, KoreaDepartment of Pathology, College of Medicine, Catholic University of Daegu, 3056-6, Daemyung-4-Dong, Nam-gu, Daegu 705-718, KoreaSchool of Biomedical Sciences, Charles Sturt University, Panorama Avenue, Bathurst, NSW 2795, AustraliaDepartment of Agricultural Biology, National Academy of Agricultural Science, RDA, 300, Nongsaengmyeong-ro, Wansan-gu, Jeonju-si, Jeollabuk-do 560-500, KoreaDepartment of Pathology, College of Medicine, Catholic University of Daegu, 3056-6, Daemyung-4-Dong, Nam-gu, Daegu 705-718, KoreaProgressive renal fibrosis is the final common pathway for all kidney diseases leading to chronic renal failure. Bee venom (BV) has been widely used as a traditional medicine for various diseases. However, the precise mechanism of BV in ameliorating the renal fibrosis is not fully understood. To investigate the therapeutic effects of BV against unilateral ureteral obstruction (UUO)-induced renal fibrosis, BV was given intraperitoneally after ureteral ligation. At seven days after UUO surgery, the kidney tissues were collected for protein analysis and histologic examination. Histological observation revealed that UUO induced a considerable increase in the number of infiltrated inflammatory cells. However, BV treatment markedly reduced these reactions compared with untreated UUO mice. The expression levels of TNF-α and IL-1β were significantly reduced in BV treated mice compared with UUO mice. In addition, treatment with BV significantly inhibited TGF-β1 and fibronectin expression in UUO mice. Moreover, the expression of α-SMA was markedly withdrawn after treatment with BV. These findings suggest that BV attenuates renal fibrosis and reduces inflammatory responses by suppression of multiple growth factor-mediated pro-fibrotic genes. In conclusion, BV may be a useful therapeutic agent for the prevention of fibrosis that characterizes progression of chronic kidney disease.http://www.mdpi.com/2072-6651/7/6/1917bee venomrenal fibrosisinflammationUUO |
| spellingShingle | Hyun Jin An Kyung Hyun Kim Woo Ram Lee Jung Yeon Kim Sun Jae Lee Sok Cheon Pak Sang Mi Han Kwan Kyu Park Anti-Fibrotic Effect of Natural Toxin Bee Venom on Animal Model of Unilateral Ureteral Obstruction Toxins bee venom renal fibrosis inflammation UUO |
| title | Anti-Fibrotic Effect of Natural Toxin Bee Venom on Animal Model of Unilateral Ureteral Obstruction |
| title_full | Anti-Fibrotic Effect of Natural Toxin Bee Venom on Animal Model of Unilateral Ureteral Obstruction |
| title_fullStr | Anti-Fibrotic Effect of Natural Toxin Bee Venom on Animal Model of Unilateral Ureteral Obstruction |
| title_full_unstemmed | Anti-Fibrotic Effect of Natural Toxin Bee Venom on Animal Model of Unilateral Ureteral Obstruction |
| title_short | Anti-Fibrotic Effect of Natural Toxin Bee Venom on Animal Model of Unilateral Ureteral Obstruction |
| title_sort | anti fibrotic effect of natural toxin bee venom on animal model of unilateral ureteral obstruction |
| topic | bee venom renal fibrosis inflammation UUO |
| url | http://www.mdpi.com/2072-6651/7/6/1917 |
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