Surgical treatment on infective endocarditis: impact of diabetes on mortality
Abstract Background Type 2 diabetes mellitus (DM) is a frequent co-morbidity among patients suffering from infective endocarditis (IE). The aim of the study was to evaluate the impact of type 2 DM on the early-, intermediate- and long-term mortality of patients who underwent surgical treatment of en...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-022-01557-x |
| _version_ | 1811328760337661952 |
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| author | Alexander Kogan Anat Wieder-Finesod Jonathan Frogel Yael Peled-Potashnik Eilon Ram Ehud Raanani Leonid Sternik |
| author_facet | Alexander Kogan Anat Wieder-Finesod Jonathan Frogel Yael Peled-Potashnik Eilon Ram Ehud Raanani Leonid Sternik |
| author_sort | Alexander Kogan |
| collection | DOAJ |
| description | Abstract Background Type 2 diabetes mellitus (DM) is a frequent co-morbidity among patients suffering from infective endocarditis (IE). The aim of the study was to evaluate the impact of type 2 DM on the early-, intermediate- and long-term mortality of patients who underwent surgical treatment of endocarditis. Methods We performed an observational cohort study in the large tertiary center in Israel during 14 years. All data of patients who underwent surgical treatment of endocarditis, performed between 2006 and 2020 were extracted from the departmental database. Patients were divided into two groups: Group I (non-diabetic patients), and Group II (diabetic patients). Results The study population includes 420 patients. Group I (non-diabetic patients), comprise 326 patients, and Group II (diabetic patients), comprise 94 patients. Mean follow-up duration was 39.3 ± 28.1 months. Short-term, 30-day and in-hospital mortality, also intermediate-term mortality (1- and 3-year) was higher in the DM group compared with the non-DM group, but did not reach statistical significance: 11.7% vs. 7.7%. (p = 0.215); 12.8% vs. 8.3% (p = 0.285); 20.2% vs. 13.2% (p = 0.1) and 23.4% vs. 15.6% (p = 0.09) respectively. Long-term, 5-year mortality was significantly higher in the DM group, compared to the non-DM group: 30.9% vs. 16.6% (p = 0.003). Furthermore, predictors for long-term mortality included diabetes (CI 1.056–2.785, p = 0.029), as demonstrated by regression analysis. Conclusions Diabetic patients have trend to increasing mortality at the short- and intermediate period post-surgery for IE, but this is not statistically significant. Survival of diabetic patients deteriorates after more than three years follow surgery. Diabetes is an independent predictor for long-term, 5-year mortality after surgical treatment of endocarditis, regardless of the patients age and comorbidities. Trial registration Ethical Committee of Sheba Medical Centre, Israel on 02.12. 2014, Protocol 4257 |
| first_indexed | 2024-04-13T15:30:39Z |
| format | Article |
| id | doaj.art-0e143c518d2a4e728b15acd4cb33b478 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-13T15:30:39Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-0e143c518d2a4e728b15acd4cb33b4782022-12-22T02:41:23ZengBMCCardiovascular Diabetology1475-28402022-06-012111710.1186/s12933-022-01557-xSurgical treatment on infective endocarditis: impact of diabetes on mortalityAlexander Kogan0Anat Wieder-Finesod1Jonathan Frogel2Yael Peled-Potashnik3Eilon Ram4Ehud Raanani5Leonid Sternik6Department of Cardiac Surgery, Sheba Medical Center, Tel Hashomer, Affiliated to the Sackler School of Medicine, Tel Aviv UniversityInfectious Disease Unit, Sheba Medical Center, Tel Hashomer, Affiliated to the Sackler School of Medicine, Tel Aviv UniversityDepartment of Anesthesiology, Sheba Medical Center, Tel Hashomer, Affiliated to the Sackler School of Medicine, Tel Aviv UniversityDivision of Cardiology, Sheba Medical Center, Tel Hashomer, Affiliated to the Sackler School of Medicine, Tel Aviv UniversityDepartment of Cardiac Surgery, Sheba Medical Center, Tel Hashomer, Affiliated to the Sackler School of Medicine, Tel Aviv UniversityDepartment of Cardiac Surgery, Sheba Medical Center, Tel Hashomer, Affiliated to the Sackler School of Medicine, Tel Aviv UniversityDepartment of Cardiac Surgery, Sheba Medical Center, Tel Hashomer, Affiliated to the Sackler School of Medicine, Tel Aviv UniversityAbstract Background Type 2 diabetes mellitus (DM) is a frequent co-morbidity among patients suffering from infective endocarditis (IE). The aim of the study was to evaluate the impact of type 2 DM on the early-, intermediate- and long-term mortality of patients who underwent surgical treatment of endocarditis. Methods We performed an observational cohort study in the large tertiary center in Israel during 14 years. All data of patients who underwent surgical treatment of endocarditis, performed between 2006 and 2020 were extracted from the departmental database. Patients were divided into two groups: Group I (non-diabetic patients), and Group II (diabetic patients). Results The study population includes 420 patients. Group I (non-diabetic patients), comprise 326 patients, and Group II (diabetic patients), comprise 94 patients. Mean follow-up duration was 39.3 ± 28.1 months. Short-term, 30-day and in-hospital mortality, also intermediate-term mortality (1- and 3-year) was higher in the DM group compared with the non-DM group, but did not reach statistical significance: 11.7% vs. 7.7%. (p = 0.215); 12.8% vs. 8.3% (p = 0.285); 20.2% vs. 13.2% (p = 0.1) and 23.4% vs. 15.6% (p = 0.09) respectively. Long-term, 5-year mortality was significantly higher in the DM group, compared to the non-DM group: 30.9% vs. 16.6% (p = 0.003). Furthermore, predictors for long-term mortality included diabetes (CI 1.056–2.785, p = 0.029), as demonstrated by regression analysis. Conclusions Diabetic patients have trend to increasing mortality at the short- and intermediate period post-surgery for IE, but this is not statistically significant. Survival of diabetic patients deteriorates after more than three years follow surgery. Diabetes is an independent predictor for long-term, 5-year mortality after surgical treatment of endocarditis, regardless of the patients age and comorbidities. Trial registration Ethical Committee of Sheba Medical Centre, Israel on 02.12. 2014, Protocol 4257https://doi.org/10.1186/s12933-022-01557-xInfective endocarditisCardiac surgeryDiabetes mellitusEpidemiologyMortality |
| spellingShingle | Alexander Kogan Anat Wieder-Finesod Jonathan Frogel Yael Peled-Potashnik Eilon Ram Ehud Raanani Leonid Sternik Surgical treatment on infective endocarditis: impact of diabetes on mortality Cardiovascular Diabetology Infective endocarditis Cardiac surgery Diabetes mellitus Epidemiology Mortality |
| title | Surgical treatment on infective endocarditis: impact of diabetes on mortality |
| title_full | Surgical treatment on infective endocarditis: impact of diabetes on mortality |
| title_fullStr | Surgical treatment on infective endocarditis: impact of diabetes on mortality |
| title_full_unstemmed | Surgical treatment on infective endocarditis: impact of diabetes on mortality |
| title_short | Surgical treatment on infective endocarditis: impact of diabetes on mortality |
| title_sort | surgical treatment on infective endocarditis impact of diabetes on mortality |
| topic | Infective endocarditis Cardiac surgery Diabetes mellitus Epidemiology Mortality |
| url | https://doi.org/10.1186/s12933-022-01557-x |
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