FIP1L1-PDGFRА-positive myeloproliferative disease with eosinophilia: A rare case with multiple organ dysfunction and a response to tyrosine kinase inhibitor therapy
The described case of FIP1L1-PDGFRА-positive myeloproliferative disease is characterized by an atypical aggressive course to develop severe specific complications as injuries to the brain, heart, lung, and intestine. Pathogenetic therapy with imatinib could stabilize a patient’s state, but failed to...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2015-12-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31887 |
| _version_ | 1818258968422645760 |
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| author | I S Nemchenko A G Turkina E Yu Chelysheva G M Galstyan A M Kovrigina N K Khuazheva V G Savchenko |
| author_facet | I S Nemchenko A G Turkina E Yu Chelysheva G M Galstyan A M Kovrigina N K Khuazheva V G Savchenko |
| author_sort | I S Nemchenko |
| collection | DOAJ |
| description | The described case of FIP1L1-PDGFRА-positive myeloproliferative disease is characterized by an atypical aggressive course to develop severe specific complications as injuries to the brain, heart, lung, and intestine. Pathogenetic therapy with imatinib could stabilize a patient’s state, but failed to produce a complete hematological response. Switching from imatinib to dasatinib could produce sustained clinical, hematological, and molecular remissions. |
| first_indexed | 2024-12-12T18:07:58Z |
| format | Article |
| id | doaj.art-0e14bdbcc0964fee84f3d820fdd9b587 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-12T18:07:58Z |
| publishDate | 2015-12-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-0e14bdbcc0964fee84f3d820fdd9b5872022-12-22T00:16:27Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422015-12-018712899528903FIP1L1-PDGFRА-positive myeloproliferative disease with eosinophilia: A rare case with multiple organ dysfunction and a response to tyrosine kinase inhibitor therapyI S NemchenkoA G TurkinaE Yu ChelyshevaG M GalstyanA M KovriginaN K KhuazhevaV G SavchenkoThe described case of FIP1L1-PDGFRА-positive myeloproliferative disease is characterized by an atypical aggressive course to develop severe specific complications as injuries to the brain, heart, lung, and intestine. Pathogenetic therapy with imatinib could stabilize a patient’s state, but failed to produce a complete hematological response. Switching from imatinib to dasatinib could produce sustained clinical, hematological, and molecular remissions.https://ter-arkhiv.ru/0040-3660/article/view/31887hypereosinophilic syndromeclonal myeloproliferative disease with eosinophiliaimatinibdasatinib |
| spellingShingle | I S Nemchenko A G Turkina E Yu Chelysheva G M Galstyan A M Kovrigina N K Khuazheva V G Savchenko FIP1L1-PDGFRА-positive myeloproliferative disease with eosinophilia: A rare case with multiple organ dysfunction and a response to tyrosine kinase inhibitor therapy Терапевтический архив hypereosinophilic syndrome clonal myeloproliferative disease with eosinophilia imatinib dasatinib |
| title | FIP1L1-PDGFRА-positive myeloproliferative disease with eosinophilia: A rare case with multiple organ dysfunction and a response to tyrosine kinase inhibitor therapy |
| title_full | FIP1L1-PDGFRА-positive myeloproliferative disease with eosinophilia: A rare case with multiple organ dysfunction and a response to tyrosine kinase inhibitor therapy |
| title_fullStr | FIP1L1-PDGFRА-positive myeloproliferative disease with eosinophilia: A rare case with multiple organ dysfunction and a response to tyrosine kinase inhibitor therapy |
| title_full_unstemmed | FIP1L1-PDGFRА-positive myeloproliferative disease with eosinophilia: A rare case with multiple organ dysfunction and a response to tyrosine kinase inhibitor therapy |
| title_short | FIP1L1-PDGFRА-positive myeloproliferative disease with eosinophilia: A rare case with multiple organ dysfunction and a response to tyrosine kinase inhibitor therapy |
| title_sort | fip1l1 pdgfrа positive myeloproliferative disease with eosinophilia a rare case with multiple organ dysfunction and a response to tyrosine kinase inhibitor therapy |
| topic | hypereosinophilic syndrome clonal myeloproliferative disease with eosinophilia imatinib dasatinib |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31887 |
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