Study on optimization of ternary complex of piroxicam-β-cyclodextrin-lysine inclusion in supercritical CO2
Piroxicam is a bioactive compound classified as a non-steroidal anti-inflammatory drug (NSAID). However, its low solubility in water imposes a serious limitation for its application in the pharmaceutical industry. Using cyclodextrins to form complexes can enhance the dissolution rate, solubility, a...
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| Format: | Article |
| Language: | English |
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Vietnam Ministry of Science and Technology
2021-09-01
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| Series: | Vietnam Journal of Science, Technology and Engineering |
| Subjects: | |
| Online Access: | https://vietnamscience.vjst.vn/index.php/vjste/article/view/61 |
| _version_ | 1797937731291054080 |
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| author | Phan Minh Vuong Do Huu Duy Khoa Phan Thanh Thao |
| author_facet | Phan Minh Vuong Do Huu Duy Khoa Phan Thanh Thao |
| author_sort | Phan Minh Vuong |
| collection | DOAJ |
| description |
Piroxicam is a bioactive compound classified as a non-steroidal anti-inflammatory drug (NSAID). However, its low solubility in water imposes a serious limitation for its application in the pharmaceutical industry. Using cyclodextrins to form complexes can enhance the dissolution rate, solubility, and bioavailability of piroxicam. In this study, piroxicam/β-cyclodextrin complexes are prepared in supercritical carbon dioxide (SC-CO2) in the solid state and the process was optimized using response surface methodology (RSM). UV-Vis spectroscopy, differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), and dissolution profile in water were used to characterized the complex under optimized temperature, residence time, moisture, and ternary agent. Finally, the maximum reaction yield of the inclusion complex was predicted to be 95% at the optimal conditions of 266 bar, 136oC, 1.84:1 ratio of cyclodextrin:piroxicam, and 1.5:1 ratio of lysine:piroxicam. Large scale production of inclusion complexes can be developed from the results of this work on optimizing conditions.
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| first_indexed | 2024-04-10T18:48:52Z |
| format | Article |
| id | doaj.art-0e1603169db64de4bda503b2bc609c4f |
| institution | Directory Open Access Journal |
| issn | 2525-2461 2615-9937 |
| language | English |
| last_indexed | 2024-04-10T18:48:52Z |
| publishDate | 2021-09-01 |
| publisher | Vietnam Ministry of Science and Technology |
| record_format | Article |
| series | Vietnam Journal of Science, Technology and Engineering |
| spelling | doaj.art-0e1603169db64de4bda503b2bc609c4f2023-02-01T08:20:03ZengVietnam Ministry of Science and TechnologyVietnam Journal of Science, Technology and Engineering2525-24612615-99372021-09-0163310.31276/VJSTE.63(3).18-23Study on optimization of ternary complex of piroxicam-β-cyclodextrin-lysine inclusion in supercritical CO2Phan Minh Vuong0Do Huu Duy Khoa1Phan Thanh Thao2Institute of Chemical Technology, Vietnam Academy of Science and TechnologyInstitute of Chemical Technology, Vietnam Academy of Science and TechnologyInstitute of Chemical Technology, Vietnam Academy of Science and Technology Piroxicam is a bioactive compound classified as a non-steroidal anti-inflammatory drug (NSAID). However, its low solubility in water imposes a serious limitation for its application in the pharmaceutical industry. Using cyclodextrins to form complexes can enhance the dissolution rate, solubility, and bioavailability of piroxicam. In this study, piroxicam/β-cyclodextrin complexes are prepared in supercritical carbon dioxide (SC-CO2) in the solid state and the process was optimized using response surface methodology (RSM). UV-Vis spectroscopy, differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), and dissolution profile in water were used to characterized the complex under optimized temperature, residence time, moisture, and ternary agent. Finally, the maximum reaction yield of the inclusion complex was predicted to be 95% at the optimal conditions of 266 bar, 136oC, 1.84:1 ratio of cyclodextrin:piroxicam, and 1.5:1 ratio of lysine:piroxicam. Large scale production of inclusion complexes can be developed from the results of this work on optimizing conditions. https://vietnamscience.vjst.vn/index.php/vjste/article/view/61β-cyclodextrinCO2 supercritical fluidpiroxicampiroxicam solubility |
| spellingShingle | Phan Minh Vuong Do Huu Duy Khoa Phan Thanh Thao Study on optimization of ternary complex of piroxicam-β-cyclodextrin-lysine inclusion in supercritical CO2 Vietnam Journal of Science, Technology and Engineering β-cyclodextrin CO2 supercritical fluid piroxicam piroxicam solubility |
| title | Study on optimization of ternary complex of piroxicam-β-cyclodextrin-lysine inclusion in supercritical CO2 |
| title_full | Study on optimization of ternary complex of piroxicam-β-cyclodextrin-lysine inclusion in supercritical CO2 |
| title_fullStr | Study on optimization of ternary complex of piroxicam-β-cyclodextrin-lysine inclusion in supercritical CO2 |
| title_full_unstemmed | Study on optimization of ternary complex of piroxicam-β-cyclodextrin-lysine inclusion in supercritical CO2 |
| title_short | Study on optimization of ternary complex of piroxicam-β-cyclodextrin-lysine inclusion in supercritical CO2 |
| title_sort | study on optimization of ternary complex of piroxicam β cyclodextrin lysine inclusion in supercritical co2 |
| topic | β-cyclodextrin CO2 supercritical fluid piroxicam piroxicam solubility |
| url | https://vietnamscience.vjst.vn/index.php/vjste/article/view/61 |
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