Performance evaluation of SimPET-L and SimPET-XL: MRI-compatible small-animal PET systems with rat-body imaging capability
Abstract Background SimPET-L and SimPET-XL have recently been introduced with increased transaxial fields of view (FOV) compared with their predecessors (SimPET™ and SimPET-X), enabling whole-body positron emission tomography (PET) imaging of rats. We conducted performance evaluations of SimPET-L an...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-03-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-023-00534-x |
| _version_ | 1797863442748538880 |
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| author | Minjee Seo Guen Bae Ko Kyeong Yun Kim Jeong-Whan Son Jung Woo Byun Yun-Sang Lee Kyeong Min Kim Jang Woo Park Kipom Kim Taekwan Lee Jae Sung Lee |
| author_facet | Minjee Seo Guen Bae Ko Kyeong Yun Kim Jeong-Whan Son Jung Woo Byun Yun-Sang Lee Kyeong Min Kim Jang Woo Park Kipom Kim Taekwan Lee Jae Sung Lee |
| author_sort | Minjee Seo |
| collection | DOAJ |
| description | Abstract Background SimPET-L and SimPET-XL have recently been introduced with increased transaxial fields of view (FOV) compared with their predecessors (SimPET™ and SimPET-X), enabling whole-body positron emission tomography (PET) imaging of rats. We conducted performance evaluations of SimPET-L and SimPET-XL and rat-body imaging with SimPET-XL to demonstrate the benefits of increased axial and transaxial FOVs. Procedures The detector blocks in SimPET-L and SimPET-XL consist of two 4 × 4 silicon photomultiplier arrays coupled with 20 × 9 array lutetium oxyorthosilicate crystals. SimPET-L and SimPET-XL have an inner diameter (bore size) of 7.6 cm, and they are composed of 40 and 80 detector blocks yielding axial lengths of 5.5 and 11 cm, respectively. Each system was evaluated according to the National Electrical Manufacturers Association NU4-2008 protocol. Rat imaging studies, such as 18F-NaF and 18F-FDG PET, were performed using SimPET-XL. Results The radial resolutions at the axial center measured using the filtered back projection, 3D ordered-subset expectation maximization (OSEM), and 3D OSEM with point spread functions correction were 1.7, 0.82, and 0.82 mm FWHM in SimPET-L and 1.7, 0.91, and 0.91 mm FWHM in SimPET-XL, respectively. The peak sensitivities of SimPET-L and SimPET-XL were 6.30% and 10.4% for an energy window of 100–900 keV and 4.44% and 7.25% for a window of 250–750 keV, respectively. The peak noise equivalent count rate with an energy window of 250–750 keV was 249 kcps at 44.9 MBq for SimPET-L and 349 kcps at 31.3 MBq for SimPET-XL. In SimPET-L, the uniformity was 4.43%, and the spill-over ratios in air- and water-filled chambers were 5.54% and 4.10%, respectively. In SimPET-XL, the uniformity was 3.89%, and the spill-over ratio in the air- and water-filled chambers were 3.56% and 3.60%. Moreover, SimPET-XL provided high-quality images of rats. Conclusion SimPET-L and SimPET-XL show adequate performance compared with other SimPET systems. In addition, their large transaxial and long axial FOVs provide imaging capability for rats with high image quality. |
| first_indexed | 2024-04-09T22:36:46Z |
| format | Article |
| id | doaj.art-0e17c72a6f754893a62a3f27b7a9f2e2 |
| institution | Directory Open Access Journal |
| issn | 2197-7364 |
| language | English |
| last_indexed | 2024-04-09T22:36:46Z |
| publishDate | 2023-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Physics |
| spelling | doaj.art-0e17c72a6f754893a62a3f27b7a9f2e22023-03-22T12:25:26ZengSpringerOpenEJNMMI Physics2197-73642023-03-0110111010.1186/s40658-023-00534-xPerformance evaluation of SimPET-L and SimPET-XL: MRI-compatible small-animal PET systems with rat-body imaging capabilityMinjee Seo0Guen Bae Ko1Kyeong Yun Kim2Jeong-Whan Son3Jung Woo Byun4Yun-Sang Lee5Kyeong Min Kim6Jang Woo Park7Kipom Kim8Taekwan Lee9Jae Sung Lee10Department of Biomedical Sciences, Seoul National University College of MedicineBrightonix Imaging Inc.Brightonix Imaging Inc.Brightonix Imaging Inc.Department of Nuclear Medicine, Seoul National University College of MedicineDepartment of Nuclear Medicine, Seoul National University College of MedicineKorea Institute of Radiological and Medical SciencesKorea Institute of Radiological and Medical SciencesBrain Research Core Facility, Korea Brain Research InstituteBrain Research Core Facility, Korea Brain Research InstituteDepartment of Biomedical Sciences, Seoul National University College of MedicineAbstract Background SimPET-L and SimPET-XL have recently been introduced with increased transaxial fields of view (FOV) compared with their predecessors (SimPET™ and SimPET-X), enabling whole-body positron emission tomography (PET) imaging of rats. We conducted performance evaluations of SimPET-L and SimPET-XL and rat-body imaging with SimPET-XL to demonstrate the benefits of increased axial and transaxial FOVs. Procedures The detector blocks in SimPET-L and SimPET-XL consist of two 4 × 4 silicon photomultiplier arrays coupled with 20 × 9 array lutetium oxyorthosilicate crystals. SimPET-L and SimPET-XL have an inner diameter (bore size) of 7.6 cm, and they are composed of 40 and 80 detector blocks yielding axial lengths of 5.5 and 11 cm, respectively. Each system was evaluated according to the National Electrical Manufacturers Association NU4-2008 protocol. Rat imaging studies, such as 18F-NaF and 18F-FDG PET, were performed using SimPET-XL. Results The radial resolutions at the axial center measured using the filtered back projection, 3D ordered-subset expectation maximization (OSEM), and 3D OSEM with point spread functions correction were 1.7, 0.82, and 0.82 mm FWHM in SimPET-L and 1.7, 0.91, and 0.91 mm FWHM in SimPET-XL, respectively. The peak sensitivities of SimPET-L and SimPET-XL were 6.30% and 10.4% for an energy window of 100–900 keV and 4.44% and 7.25% for a window of 250–750 keV, respectively. The peak noise equivalent count rate with an energy window of 250–750 keV was 249 kcps at 44.9 MBq for SimPET-L and 349 kcps at 31.3 MBq for SimPET-XL. In SimPET-L, the uniformity was 4.43%, and the spill-over ratios in air- and water-filled chambers were 5.54% and 4.10%, respectively. In SimPET-XL, the uniformity was 3.89%, and the spill-over ratio in the air- and water-filled chambers were 3.56% and 3.60%. Moreover, SimPET-XL provided high-quality images of rats. Conclusion SimPET-L and SimPET-XL show adequate performance compared with other SimPET systems. In addition, their large transaxial and long axial FOVs provide imaging capability for rats with high image quality.https://doi.org/10.1186/s40658-023-00534-xPET/MRIMolecular imagingNEMA performanceInstrumentation |
| spellingShingle | Minjee Seo Guen Bae Ko Kyeong Yun Kim Jeong-Whan Son Jung Woo Byun Yun-Sang Lee Kyeong Min Kim Jang Woo Park Kipom Kim Taekwan Lee Jae Sung Lee Performance evaluation of SimPET-L and SimPET-XL: MRI-compatible small-animal PET systems with rat-body imaging capability EJNMMI Physics PET/MRI Molecular imaging NEMA performance Instrumentation |
| title | Performance evaluation of SimPET-L and SimPET-XL: MRI-compatible small-animal PET systems with rat-body imaging capability |
| title_full | Performance evaluation of SimPET-L and SimPET-XL: MRI-compatible small-animal PET systems with rat-body imaging capability |
| title_fullStr | Performance evaluation of SimPET-L and SimPET-XL: MRI-compatible small-animal PET systems with rat-body imaging capability |
| title_full_unstemmed | Performance evaluation of SimPET-L and SimPET-XL: MRI-compatible small-animal PET systems with rat-body imaging capability |
| title_short | Performance evaluation of SimPET-L and SimPET-XL: MRI-compatible small-animal PET systems with rat-body imaging capability |
| title_sort | performance evaluation of simpet l and simpet xl mri compatible small animal pet systems with rat body imaging capability |
| topic | PET/MRI Molecular imaging NEMA performance Instrumentation |
| url | https://doi.org/10.1186/s40658-023-00534-x |
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